| DYNLT1 gene expression is downregulated in whole blood of patients at different Huntington's disease stages. | DYNLT1 gene expression is downregulated in whole blood of patients at different Huntington's disease stages.
Rosseto SM, Alarcon TA, Rocha DMC, Ribeiro FM, Ferguson SSG, Martins-Silva C, Muniz MR, Costa PF, Guimarães DA, Pires RGW. | 08/21/2021 |
| Beclin1 mRNA and protein were significantly increased in spermatozoa from infertile patients of different etiologies in comparison to healthy controls. However, DYNLT1 mRNA expression was significantly decreased in infertile groups than controls. Mature spermatozoa extracted from all studied subjects showed increased DYNLT1 mRNA and decreased Beclin1 mRNA and protein expression compared with the whole sample. | Relationship between DYNLT1 and Beclin1 expression and the fertilising potential of human spermatozoa.
Elzeiny D, Monir R, El Sabakhawy K, Selim MK, Zalata A. | 04/4/2020 |
| expression of Tctex-1 T94E did not influence KIM-1-mediated efferocytosis | Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.
Ismail OZ, Sriranganathan S, Zhang X, Bonventre JV, Zervos AS, Gunaratnam L., Free PMC Article | 10/5/2019 |
| MAP4 and Tctex-1 play important roles in regulating the migration of epidermal cells under hypoxia. | MAP4 regulates Tctex-1 and promotes the migration of epidermal cells in hypoxia.
Chen X, Zhou X, Shi X, Xia X, Zhang Y, Fan D. | 08/17/2019 |
| siRNA silencing of Tctex1 suppressed cellular viability and promoted cell apoptosis. Protein and mRNA expression of Tctex1 and dynein decreased after Tctex1 knockdown, whereas alpha-synuclein, LC3-II, and LAMP2 increased. Consistently, fluorescence intensity of Tctex1 was weaker in siRNA-Tctex1-transfected cells, and that of alpha-synuclein, LC3-II, and LAMP2 was increased. | Silencing of Tctex1 impairs autophagy lysosomal degradation of α-synuclein and cell viability.
Zhang Y, Dong S, Liu Z, Ming J, Sun Z, Li X, Cai ZL, Li X. | 04/6/2019 |
| Tctex1 overexpression promoted autophagy lysosome fusion and effectively degraded alpha-synuclein with increased cell activity | Tctex1 plays a key role in the α-synuclein autophagy lysosomal degradation pathway.
Dong S, Zhang Y, Ming J, Zhang X, Li X, Xu J, Sun Z, Cai Z, Li X. | 07/28/2018 |
| Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination. | Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.
Nekrasova O, Harmon RM, Broussard JA, Koetsier JL, Godsel LM, Fitz GN, Gardel ML, Green KJ., Free PMC Article | 04/21/2018 |
| results support a model in which phospho(T94)Tctex-1-regulated actin polymerization and periciliary endocytosis play an active role in orchestrating the initial phase of ciliary resorption | Tctex-1 controls ciliary resorption by regulating branched actin polymerization and endocytosis.
Saito M, Otsu W, Hsu KS, Chuang JZ, Yanagisawa T, Shieh V, Kaitsuka T, Wei FY, Tomizawa K, Sung CH., Free PMC Article | 03/31/2018 |
| DYNLT1 interacts with nucleoporins and plays a role in the dysregulation of gene expression and induction of hematopoietic cell proliferation by the leukemogenic nucleoporin fusion, NUP98-HOXA9 | Dynein Light Chain 1 (DYNLT1) Interacts with Normal and Oncogenic Nucleoporins.
Sarma NJ, Yaseen NR., Free PMC Article | 10/14/2017 |
| activin receptor IIB as a novel DYNLT1 ligand and suggest that DYNLT1 functions as a molecular dimerization engine bringing together two receptor monomers in the cytoplasmic side of the membrane. | Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.
Merino-Gracia J, Zamora-Carreras H, Bruix M, Rodríguez-Crespo I., Free PMC Article | 05/20/2017 |
| Study reports a defect in the expression of DYNLT1 in the germ cells of infertile human males and implicates DYNLT1 in spermatogonial cell division and differentiation. | Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.
Indu S, Sekhar SC, Sengottaiyan J, Kumar A, Pillai SM, Laloraya M, Kumar PG., Free PMC Article | 10/22/2016 |
| The results implicate MTs/DYNLT1 as drivers of Vpr nuclear import and HIV infection, with important therapeutic implications. | Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate.
Caly L, Kassouf VT, Moseley GW, Diefenbach RJ, Cunningham AL, Jans DA. | 06/28/2016 |
| Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2) are equally able to bind to small GTPases Rab3D (Rab3d GTPase) and RagA (Ras-related GTP binding A). | DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor.
Merino-Gracia J, García-Mayoral MF, Rapali P, Valero RA, Bruix M, Rodríguez-Crespo I. | 04/30/2016 |
| Reveal a dynein independent role of Tctex-1 at the kinetochore to enhance the stability of kinetochore-microtubule attachment. | A dynein independent role of Tctex-1 at the kinetochore.
Liu C, Chuang JZ, Sung CH, Mao Y., Free PMC Article | 02/27/2016 |
| DYNLT1 is enriched at focal concentrations of CT850 on the chlamydial inclusion membrane that are known to interact with dynein and microtubules. | Chlamydia trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 (Tctex1).
Mital J, Lutter EI, Barger AC, Dooley CA, Hackstadt T., Free PMC Article | 08/8/2015 |
| Data suggest that DYNLT1 phosphorylation at serine S82 is involved in microtubule and mitochondria regulation, and their interaction and cooperation contribute to the cellular hypoxic tolerance. | Phosphorylation of DYNLT1 at serine 82 regulates microtubule stability and mitochondrial permeabilization in hypoxia.
Xu X, Zhang Q, Hu JY, Zhang DX, Jiang XP, Jia JZ, Zhu JC, Huang YS., Free PMC Article | 06/7/2014 |
| there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization | MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.
Fang YD, Xu X, Dang YM, Zhang YM, Zhang JP, Hu JY, Zhang Q, Dai X, Teng M, Zhang DX, Huang YS., Free PMC Article | 07/21/2012 |
| Dynlt1 modulates orexin signaling by regulating OX1R | Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
Duguay D, Bélanger-Nelson E, Mongrain V, Beben A, Khatchadourian A, Cermakian N., Free PMC Article | 02/25/2012 |
| A role for Tctex-1 (DYNLT1) in controlling primary cilium length | A role for Tctex-1 (DYNLT1) in controlling primary cilium length.
Palmer KJ, MacCarthy-Morrogh L, Smyllie N, Stephens DJ., Free PMC Article | 12/31/2011 |
| A link between REIC/Dkk- 3 and Tctex-1 may therefore be of significance for understanding the molecular functions of the proteins in ER stress signaling and the intracellular dynein motor dynamics, respectively. | Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1.
Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H. | 10/22/2011 |
| These data show that Tctex-1 may play a role in late stages of viral replication through its interaction with the flavivirus membrane protein. | The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Brault JB, Kudelko M, Vidalain PO, Tangy F, Desprès P, Pardigon N. | 10/22/2011 |
| Data show that Tctex-1 phosphorylated at Thr 94 is recruited to ciliary transition zones before S-phase entry and has a pivotal role in both ciliary disassembly and cell cycle progression. | Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors.
Li A, Saito M, Chuang JZ, Tseng YY, Dedesma C, Tomizawa K, Kaitsuka T, Sung CH., Free PMC Article | 06/4/2011 |
| Targeted disruption of Tctex-1 by RNA interference significantly impairs bone resorption capacity and mislocalizes Rab3D vesicles in osteoclasts. | Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.
Pavlos NJ, Cheng TS, Qin A, Ng PY, Feng HT, Ang ES, Carrello A, Sung CH, Jahn R, Zheng MH, Xu J., Free PMC Article | 05/21/2011 |
| These data show that both DYNLT1 and DYNLT3 interact with L2 of human papillomavirus 16 during virus infection. | Identification of the dynein light chains required for human papillomavirus infection.
Schneider MA, Spoden GA, Florin L, Lambert C. | 04/2/2011 |
| The N-terminal half of pUL35, in particular residues 30-43, was identified as a common region for the binding of DYNLT1 and DYNLT3. | Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26).
Apcarian A, Cunningham AL, Diefenbach RJ. | 11/6/2010 |