| Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells. | Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells.
Pham QT, Taniyama D, Akabane S, Takashima T, Maruyama R, Sekino Y, Sentani K, Yasui W, Oue N. | 01/28/2023 |
| Tryptophan degradation enzymes and Angiotensin (1-7) expression in human placenta. | Tryptophan degradation enzymes and Angiotensin (1-7) expression in human placenta.
Silvano A, Seravalli V, Strambi N, Tartarotti E, Tofani L, Calosi L, Parenti A, Di Tommaso M. | 10/8/2022 |
| High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis. | High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis.
Rong G, Zhang T, Xu Y, Zhang Z, Gui B, Hu K, Zhang J, Tang Z, Shen C., Free PMC Article | 07/2/2022 |
| Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis. | Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
Chang Y, Han P, Wang Y, Jia C, Zhang B, Zhao Y, Li S, Li S, Wang X, Yang X, Wei W. | 05/21/2022 |
| TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer. | TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer.
Pham QT, Taniyama D, Akabane S, Harada K, Babasaki T, Sekino Y, Hayashi T, Sakamoto N, Sentani K, Oue N, Yasui W., Free PMC Article | 03/12/2022 |
| MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma. | MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma.
Ai Y, Luo S, Wang B, Xiao S, Wang Y., Free PMC Article | 02/19/2022 |
| Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism. | Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism.
Trézéguet V, Fatrouni H, Merched AJ., Free PMC Article | 01/22/2022 |
| Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer. | Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer.
Miyazaki T, Chung S, Sakai H, Ohata H, Obata Y, Shiokawa D, Mizoguchi Y, Kubo T, Ichikawa H, Taniguchi H, Aoki K, Soga T, Nakagama H, Okamoto K., Free PMC Article | 01/15/2022 |
| IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer. | IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer.
Liang H, Li T, Fang X, Xing Z, Zhang S, Shi L, Li W, Guo L, Kuang C, Liu H, Yang Q. | 01/8/2022 |
| Tryptophan 2, 3dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells. | Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells.
Zhao Y, Tao F, Jiang J, Chen L, Du J, Cheng X, He Q, Zhong S, Chen W, Wu X, Ou R, Xu Y, Tang KF., Free PMC Article | 10/23/2021 |
| Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway. | Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.
Du L, Xing Z, Tao B, Li T, Yang D, Li W, Zheng Y, Kuang C, Yang Q., Free PMC Article | 10/9/2021 |
| TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27. | TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27.
Yu C, Rao D, Zhu H, Liu Q, Huang W, Zhang L, Liang H, Song J, Ding Z., Free PMC Article | 10/2/2021 |
| TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway. | TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway.
Zhao L, Wang B, Yang C, Lin Y, Zhang Z, Wang S, Ye Y, Shen Z. | 06/26/2021 |
| Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines. | Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines.
Paccosi S, Cecchi M, Silvano A, Fabbri S, Parenti A., Free PMC Article | 12/5/2020 |
| Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer. | Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer.
Ghafouri-Fard S, Taherian-Esfahani Z, Dashti S, Kholghi Oskooei V, Taheri M, Samsami M. | 10/31/2020 |
| Hypoxia Inducible Factor 1alpha Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma. | Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.
Mohapatra SR, Sadik A, Tykocinski LO, Dietze J, Poschet G, Heiland I, Opitz CA., Free PMC Article | 10/31/2020 |
| Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers. | Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.
Hoffmann D, Dvorakova T, Stroobant V, Bouzin C, Daumerie A, Solvay M, Klaessens S, Letellier MC, Renauld JC, van Baren N, Lelotte J, Marbaix E, Van den Eynde BJ. | 10/3/2020 |
| HOXC10 directly binds to the PD-L2 and TDO2 promoter regions thus stimulating proliferation, invasion and induction of immunosuppressive gene expression in glioma. | HOXC10 promotes proliferation and invasion and induces immunosuppressive gene expression in glioma.
Li S, Zhang W, Wu C, Gao H, Yu J, Wang X, Li B, Jun Z, Zhang W, Zhou P, Shi J, Wang L, Gao Y, Li S, Tao B. | 04/13/2019 |
| TDO2 overexpression was related to poor prognosis and associated with cancer cell proliferation and tumor stem cells in esophageal squamous cell carcinoma. | TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma.
Pham QT, Oue N, Sekino Y, Yamamoto Y, Shigematsu Y, Sakamoto N, Sentani K, Uraoka N, Yasui W. | 11/10/2018 |
| Study demonstrated that n-butylidenephthalide (n-BP)functions by regulating the early part of the kynurenine pathway through the downregulation of tryptophan 2, 3-dioxygenase (TDO2), which decreases the downstream neurotoxic product, quinolinic acid (QA). Findings indicate a correlation between n-BP, TDO2, QA, calpain, and toxic fragment formation. | n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Rajamani K, Liu JW, Wu CH, Chiang IT, You DH, Lin SY, Hsieh DK, Lin SZ, Harn HJ, Chiou TW. | 05/5/2018 |
| the potent antimicrobial as well as immunoregulatory effects of TDO were substantially impaired under hypoxic conditions that pathophysiologically occur in vivo. This might be detrimental for the appropriate host immune response towards relevant pathogens. | Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function.
Elbers F, Woite C, Antoni V, Stein S, Funakoshi H, Nakamura T, Schares G, Däubener W, Eller SK., Free PMC Article | 05/20/2017 |
| High TDO2 expression is associated with Colorectal Cancer. | Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer.
Chen IC, Lee KH, Hsu YH, Wang WR, Chen CM, Cheng YW., Free PMC Article | 02/25/2017 |
| Crystal tryptophan 2,3-dioxygenase structure revealed eight residues playing critical roles in L-tryptophan oxidation. | Structural and functional analyses of human tryptophan 2,3-dioxygenase.
Meng B, Wu D, Gu J, Ouyang S, Ding W, Liu ZJ. | 10/31/2015 |
| IL-1beta is suggested to stimulate tryptophan catabolism and production of IL-6 and IL-8 by increasing TDO expression in endometriosis. | IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells.
Urata Y, Koga K, Hirota Y, Akiyama I, Izumi G, Takamura M, Nagai M, Harada M, Hirata T, Yoshino O, Kawana K, Fujii T, Osuga Y. | 06/20/2015 |
| Identification of 12 polymorphisms in the human TDO2 promoter region, 2 of them corresponding to previously unknown single-nucleotide polymorphisms and 3 of them located in putative glucocorticoid-responsive elements. | Characterization of functional polymorphisms and glucocorticoid-responsive elements in the promoter of TDO2, a candidate gene for ethanol-induced behavioural disorders.
Soichot M, Vaast A, Vignau J, Guillemin GJ, Lhermitte M, Broly F, Allorge D. | 03/1/2014 |