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    TFF3 trefoil factor 3 [ Homo sapiens (human) ]

    Gene ID: 7033, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Different Molecular Forms of TFF3 in the Human Respiratory Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and Proteolytic Cleavage in Bronchial Secretions.

    Different Molecular Forms of TFF3 in the Human Respiratory Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and Proteolytic Cleavage in Bronchial Secretions.
    Weste J, Houben T, Harder S, Schlüter H, Lücke E, Schreiber J, Hoffmann W., Free PMC Article

    01/7/2023
    Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with linear growth and biomarkers of environmental enteric dysfunction (EED) in Bangladeshi children.

    Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with linear growth and biomarkers of environmental enteric dysfunction (EED) in Bangladeshi children.
    Hasan MM, Gazi MA, Das S, Fahim SM, Hossaini F, Khan AR, Ferdous J, Alam MA, Mahfuz M, Ahmed T., Free PMC Article

    08/27/2022
    TFF3 promotes pituitary tumor cell migration and angiogenesis via VEGFA.

    TFF3 promotes pituitary tumor cell migration and angiogenesis via VEGFA.
    Wang X, Qin H.

    07/30/2022
    The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients.

    The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients.
    Keles Yucel ZP, Afacan B, Atmaca İlhan H, Kose T, Emingil G.

    05/14/2022
    Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression.

    Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression.
    Cheng F, Wang X, Chiou YS, He C, Guo H, Tan YQ, Basappa B, Zhu T, Pandey V, Lobie PE., Free PMC Article

    04/23/2022
    Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective.

    Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective.
    Yang Y, Lin Z, Lin Q, Bei W, Guo J., Free PMC Article

    04/16/2022
    Low expression of TFF3 in papillary thyroid carcinoma may correlate with poor prognosis but high immune cell infiltration.

    Low expression of TFF3 in papillary thyroid carcinoma may correlate with poor prognosis but high immune cell infiltration.
    Yang L, Zhang X, Zhang J, Liu Y, Ji T, Mou J, Fang X, Wang S, Chen J.

    03/5/2022
    CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression.

    CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression.
    Cui HY, Wang SJ, Song F, Cheng X, Nan G, Zhao Y, Qian MR, Chen X, Li JY, Liu FL, Zhu YM, Tian RF, Wang B, Wu B, Zhang Y, Sun XX, Guo T, Yang XM, Zhang H, Li L, Xu J, Bian HJ, Jiang JL, Chen ZN., Free PMC Article

    03/5/2022
    Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer.

    Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer.
    Samson MH, Abildgaard AM, Espelund U, Rasmussen TR, Folkersen B, Frystyk J, Nexo E.

    03/5/2022
    Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host.

    Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host.
    Adewale B, Heintz JR, Pastore CF, Rossi HL, Hung LY, Rahman N, Bethony J, Diemert D, Babatunde JA, Herbert DR., Free PMC Article

    12/25/2021
    Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3alpha and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis.

    Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3α and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis.
    Yang J, Syed F, Xia Y, Sanyal AJ, Shah VH, Chalasani N, Zheng X, Yu Q, Lou Y, Li W., Free PMC Article

    12/4/2021
    Overexpression of trefoil factor 1 and trefoil factor 3 in primary extramammary Paget's disease and implication of a novel therapeutic target.

    Overexpression of trefoil factor 1 and trefoil factor 3 in primary extramammary Paget's disease and implication of a novel therapeutic target.
    Zhu R, Liu Y, Yan J, Tian Y, Yan W, Aryal S, Tan F, Chen Y, Tang Y, Bai Y.

    11/22/2021
    The diagnostic and clinicopathological value of trefoil factor 3 in patients with gastric cancer: a systematic review and meta-analysis.

    The diagnostic and clinicopathological value of trefoil factor 3 in patients with gastric cancer: a systematic review and meta-analysis.
    Zhang CX, Wu CT, Xiao L, Tang SH.

    11/6/2021
    HOXB13 and TFF3 can contribute to the prognostic stratification of prostate adenocarcinoma.

    HOXB13 and TFF3 can contribute to the prognostic stratification of prostate adenocarcinoma.
    Timofte AD, Giuşcă SE, Lozneanu L, Manole MB, Prutianu I, Gafton B, Rusu A, Căruntu ID., Free PMC Article

    10/30/2021
    Elevated trefoil factor 3 plasma levels in critically ill patients with abdominal sepsis or non-infectious abdominal illness.

    Elevated trefoil factor 3 plasma levels in critically ill patients with abdominal sepsis or non-infectious abdominal illness.
    Meijer MT, Uhel F, Cremer OL, Scicluna BP, Schultz MJ, van der Poll T, MARS consortium.

    10/9/2021
    TFF3 mediates the NF-kappaB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis.

    TFF3 mediates the NF-κB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis.
    Liu J, Yang Q, Chen Z, Lv S, Tang J, Xing Z, Shi M, Lei A, Xiao G, He Y.

    10/2/2021
    Evaluation of inflammatory bowel disease activity in children using serum trefoil factor peptide.

    Evaluation of inflammatory bowel disease activity in children using serum trefoil factor peptide.
    Teng X, Yang Y, Liu L, Yang L, Wu J, Sun M, Xu L.

    10/2/2021
    Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

    Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.
    Braga Emidio N, Meli R, Tran HNT, Baik H, Morisset-Lopez S, Elliott AG, Blaskovich MAT, Spiller S, Beck-Sickinger AG, Schroeder CI, Muttenthaler M., Free PMC Article

    09/11/2021
    LINC00160 mediated paclitaxel-And doxorubicin-resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPbeta.

    LINC00160 mediated paclitaxel-And doxorubicin-resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ.
    Wu H, Gu J, Zhou D, Cheng W, Wang Y, Wang Q, Wang X., Free PMC Article

    05/15/2021
    Comparison of Serum Trefoil Factor-3 to Endoscopy in Diagnosing Helicobacter Pylori Associated Gastric Ulcer.

    Comparison of Serum Trefoil Factor-3 to Endoscopy in Diagnosing Helicobacter Pylori Associated Gastric Ulcer.
    Ramadan RA, Zaki MA, Ooda SA, Abo Khalifa HM, Ragab WS., Free PMC Article

    04/13/2021
    Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection.

    Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection.
    Whary MT, Avenia JMR, Bravo LE, Lofgren JL, Lertpiriyapong K, Mera-Giler R, Piazuelo MB, Correa P, Peek RM Jr, Wilson KT, Fox JG., Free PMC Article

    02/6/2021
    Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial.

    Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial.
    Fitzgerald RC, di Pietro M, O'Donovan M, Maroni R, Muldrew B, Debiram-Beecham I, Gehrung M, Offman J, Tripathi M, Smith SG, Aigret B, Walter FM, Rubin G, BEST3 Trial team, Sasieni P., Free PMC Article

    08/29/2020
    Trefoil factors share a lectin activity that defines their role in mucus.

    Trefoil factors share a lectin activity that defines their role in mucus.
    Järvå MA, Lingford JP, John A, Soler NM, Scott NE, Goddard-Borger ED., Free PMC Article

    08/15/2020
    Patients with active ulcerative colitis (UC) had higher serum TFF3 levels than those with quiescent UC and controls. Serum TFF3 levels correlated with fecal calprotectin (FC) values and with endoscopic activity in patients with active and quiescent UC. Serum TFF3 is able to identify patients with active UC and it could be used as a marker to predict disease activity.

    Serum trefoil factor 3 predicts disease activity in patients with ulcerative colitis.
    Nakov R, Velikova T, Nakov V, Ianiro G, Gerova V, Tankova L.

    07/25/2020
    TFF3 was shown to regulate ATG12 in human colon adenocarcinoma cells in vitro

    Trefoil factor 3 knock-down prevents autophagy-related gene 12 elevation in colon adenocarcinoma.
    Zhang Z.

    07/11/2020
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