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    THBD thrombomodulin [ Homo sapiens (human) ]

    Gene ID: 7056, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Altered release of thrombomodulin and HMGB1 in the placenta complicated with preeclampsia.

    Altered release of thrombomodulin and HMGB1 in the placenta complicated with preeclampsia.
    Oda H, Nagamatsu T, Iriyama T, Osuga Y.

    03/19/2024
    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.

    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.
    Biswas I, Giri H, Panicker SR, Rezaie AR.,

    02/23/2024
    The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.

    The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.
    Chang YJ, Prince GMSH, Wei PL, Batzorig U, Huang CY, Hung CS, Chang TC.

    01/26/2024
    Novel nucleotide variations in the thrombomodulin (THBD) gene involved in coagulation pathways can increase the risk of recurrent pregnancy loss (RPL).

    Novel nucleotide variations in the thrombomodulin (THBD) gene involved in coagulation pathways can increase the risk of recurrent pregnancy loss (RPL).
    Heidari MM, Mazrouei B, Tahmasebi M, Bagheri F, Khanjankhani Z, Khatami M, Dehghani M, Khormizi FZ.

    01/16/2024
    Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality.

    Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality.
    Yamazaki A, Nukui Y, Kameda T, Saito R, Koda Y, Ichimura N, Tohda S, Ohkawa R., Free PMC Article

    12/18/2023
    On the relevance of thrombomodulin variants in atypical hemolytic uremic syndrome.

    On the relevance of thrombomodulin variants in atypical hemolytic uremic syndrome.
    Huerta A, Arjona E, Portoles J, Lopez-Sanchez P, Cavero T, Fernandez-Cusicanqui J, Blasco M, Cabello V, Calvo N, Diaz M, Herrero-Goñi M, Aguirre M, Elías S, Alcaide MP, Ramos N, Sellares J, Rodríguez de Córdoba S.

    09/28/2023
    A missense mutation in lectin domain of thrombomodulin causing functional deficiency.

    A missense mutation in lectin domain of thrombomodulin causing functional deficiency.
    Jiewen M, Yanyi T, Yuanzheng F, Zhipeng C, Wenyi L, Bei H, Yu H, Tang LV.

    12/24/2022
    Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study.

    Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study.
    Zhu Z, Guo D, Jia Y, Zhang K, Shi M, Peng Y, Yang P, Chen J, Zhang J, Wang A, Xu T, Zhang Y, He J.

    09/3/2022
    Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy.

    Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy.
    Voelker MT, Hechaichi N, Ndongson-Dongmo B, Lemm J, Heller R, Bauer R, Conway EM, Theilmeier G, Stehr SN.

    08/27/2022
    Association of SNP (rs1042579) in thrombomodulin gene and plasma thrombomodulin level in North Indian children with Kawasaki disease.

    Association of SNP (rs1042579) in thrombomodulin gene and plasma thrombomodulin level in North Indian children with Kawasaki disease.
    Singh A, Rawat A, Kaur A, Kaur A, Kumrah R, Johnson N, Chaudhary H, Pilania RK, Srivastava P, Singh S.

    07/30/2022
    Aberrant promoter hypermethylation regulates thrombomodulin in high altitude induced deep vein thrombosis.

    Aberrant promoter hypermethylation regulates thrombomodulin in high altitude induced deep vein thrombosis.
    Vijay A, Jha PK, Parveen S, Goel S, Prabhakar A, Sharma S, Kumar B, Chatterjee T, Bajaj N, Nair V, Sharma M, Ashraf MZ.

    06/18/2022
    Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study.

    Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study.
    Manderstedt E, Halldén C, Lind-Halldén C, Elf J, Svensson PJ, Engström G, Melander O, Baras A, Lotta LA, Zöller B, Regeneron Genetics Center.

    04/30/2022
    How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.

    How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.
    Peacock RB, McGrann T, Zaragoza S, Komives EA., Free PMC Article

    02/19/2022
    MiR-18a-5p Promotes Proliferation, Migration, and Invasion of Endometrial Cancer Cells by Targeting THBD.

    MiR-18a-5p Promotes Proliferation, Migration, and Invasion of Endometrial Cancer Cells by Targeting THBD.
    Dong H, Li Y, Zhou J, Song J.

    02/19/2022
    Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs.

    Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs.
    Won T, Wood MK, Hughes DM, Talor MV, Ma Z, Schneider J, Skinner JT, Asady B, Goerlich E, Halushka MK, Hays AG, Kim DH, Parikh CR, Rosenberg AZ, Coppens I, Johns RA, Gilotra NA, Hooper JE, Pekosz A, Čiháková D., Free PMC Article

    02/5/2022
    Association study of polymorphism in Thrombomodulin gene [rs1042579] with cardiovascular disease.

    Association study of polymorphism in Thrombomodulin gene [rs1042579] with cardiovascular disease.
    Khosravi E, Sadeghian L, Mohamadynejad P, Dianatkhah M, Hajizadeh M, Gharipour M., Free PMC Article

    01/29/2022
    Thrombomodulin is upregulated in the kidneys of women with pre-eclampsia.

    Thrombomodulin is upregulated in the kidneys of women with pre-eclampsia.
    van Aanhold CCL, Bos M, Mirabito Colafella KM, van der Hoorn MP, Wolterbeek R, Bruijn JA, Bloemenkamp KWM, van den Meiracker AH, Danser AHJ, Baelde HJ., Free PMC Article

    12/11/2021
    Thrombomodulin in patients with mild to moderate bleeding tendency.

    Thrombomodulin in patients with mild to moderate bleeding tendency.
    Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Downes K, Haimel M, Pabinger I, Gebhart J., Free PMC Article

    11/22/2021
    Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Kruppel-like Factor 2 Pathway in Endothelial Cells.

    Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Krüppel-like Factor 2 Pathway in Endothelial Cells.
    Wu CH, Chiu YL, Hsieh CY, Tsung GS, Wu LS, Cheng CC, Tsai TN., Free PMC Article

    11/6/2021
    The associations between THBD c.1418C>T polymorphism and lower extremity deep vein thrombosis or endothelial progenitor cell.

    The associations between THBD c.1418C>T polymorphism and lower extremity deep vein thrombosis or endothelial progenitor cell.
    Zhang P, Gong K, Zhang L, Xiao L, Guo S, Li Y, Zhang J.

    11/6/2021
    Recombinant human thrombomodulin for pneumonia-induced severe ARDS complicated by DIC in children: a preliminary study.

    Recombinant human thrombomodulin for pneumonia-induced severe ARDS complicated by DIC in children: a preliminary study.
    Hirata N, Ngo DT, Phan PH, Ainai A, Phung TTB, Ta TA, Takasaki J, Kawachi S, Nunoi H, Nakajima N, Dien TM., Free PMC Article

    10/23/2021
    Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells.

    Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells.
    Giri H, Panicker SR, Cai X, Biswas I, Weiler H, Rezaie AR., Free PMC Article

    09/11/2021
    Value of Thrombomodulin as a Marker for Sepsis in Critically Ill Children.

    Value of Thrombomodulin as a Marker for Sepsis in Critically Ill Children.
    Khattab AA, Dawood AAER, Saleh NY.

    09/4/2021
    Thrombomodulin gene polymorphism and the occurrence and prognostic value of sepsis acute kidney injury.

    Thrombomodulin gene polymorphism and the occurrence and prognostic value of sepsis acute kidney injury.
    Li Q, Yang W, Zhao K, Sun X, Bao L., Free PMC Article

    07/10/2021
    Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression.

    Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression.
    Kohli S, Singh KK, Gupta A, Markmeyer P, Lochmann F, Gupta D, Rana R, Elwakiel A, Huebner H, Ruebner M, Isermann B.

    07/3/2021
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