| RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation. | RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.
Zhang T, Zheng H, Lu D, Guan G, Li D, Zhang J, Liu S, Zhao J, Guo JT, Lu F, Chen X., Free PMC Article | 09/18/2023 |
| Depletion of TIAR accelerates mitotic entry and leads to chromosomal instability in response to replication stress, in a manner that can be alleviated by the concomitant depletion of Cdc25B or inhibition of CDK1. Since TIAR retains CDK1 in GMGs and attenuates CDK1 activity, we propose that the assembly of GMGs may represent a so far unrecognized mechanism that contributes to the activation of the G2/M checkpoint | TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.
Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, Lopez-Contreras AJ, Gruss OJ, Erhardt S, Mendez J, Fernandez-Capetillo O, Stoecklin G., Free PMC Article | 08/17/2019 |
| The manipulation of miR2233p/TIAL1 interaction may be involved in the neuroprotective effects of DEX. | miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro.
Wang Q, Yu H, Yu H, Ma M, Ma Y, Li R., Free PMC Article | 06/1/2019 |
| Data indicate that both ELAVL1 and TIAR positively regulate endogenous SNCA in vivo. | Discovering the 3' UTR-mediated regulation of alpha-synuclein.
Marchese D, Botta-Orfila T, Cirillo D, Rodriguez JA, Livi CM, Fernández-Santiago R, Ezquerra M, Martí MJ, Bechara E, Tartaglia GG, Catalan MSA Registry (CMSAR)., Free PMC Article | 01/20/2018 |
| we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR | LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.
Liu L, Yue H, Liu Q, Yuan J, Li J, Wei G, Chen X, Lu Y, Guo M, Luo J, Chen R., Free PMC Article | 12/16/2017 |
| Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein) contribute to mRNA stability as cis-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability. | Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.
Motohashi H, Mukudai Y, Ito C, Kato K, Shimane T, Kondo S, Shirota T. | 06/24/2017 |
| results suggest that TIA-1 and TIAR are two new host factors that interact with 5-UTR of EV71 genome and positively regulate viral replication | TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.
Wang X, Wang H, Li Y, Jin Y, Chu Y, Su A, Wu Z. | 01/16/2016 |
| TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1-Exon8 mRNA levels. | HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
Zhao W, Zhao J, Hou M, Wang Y, Zhang Y, Zhao X, Zhang C, Guo D., Free PMC Article | 04/4/2015 |
| TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. | Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression.
Carrascoso I, Sánchez-Jiménez C, Izquierdo JM., Free PMC Article | 01/17/2015 |
| A role for TIAR is identified in T-cells for control of translational specificity. | Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.
Carrascoso I, Sánchez-Jiménez C, Izquierdo JM. | 08/16/2014 |
| findings demonstrate that TIAR recognition motif 2 (RRM2), together with its C-terminal extension, is the major contributor for the high-affinity (nM) interactions of TIAR with target RNA sequences | Distinct binding properties of TIAR RRMs and linker region.
Kim HS, Headey SJ, Yoga YM, Scanlon MJ, Gorospe M, Wilce MC, Wilce JA., Free PMC Article | 01/18/2014 |
| TIA1 and TIAR proteins are intron-associated positive regulators of SMN2 exon 7 splicing. | TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.
Singh NN, Seo J, Ottesen EW, Shishimorova M, Bhattacharya D, Singh RN., Free PMC Article | 04/9/2011 |
| Severe hypoxia caused co-aggregation of TIAR/TIA-1 and these proteins suppressed HIF-1alpha expression. | TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway.
Gottschald OR, Malec V, Krasteva G, Hasan D, Kamlah F, Herold S, Rose F, Seeger W, Hänze J. | 03/19/2011 |
| Data show that TIA1 and TIAL1 bind at the same positions on human RNAs, and are consistent with a model where TIA proteins shorten the time available for definition of an alternative exon by enhancing recognition of the preceding 5' splice site. | iCLIP predicts the dual splicing effects of TIA-RNA interactions.
Wang Z, Kayikci M, Briese M, Zarnack K, Luscombe NM, Rot G, Zupan B, Curk T, Ule J., Free PMC Article | 02/26/2011 |
| Data show that apoptotic (TIAR and TIA-1) marker expression in thyroid tissues from adolescents with immune thyroid diseases is higher than in non-immune thyroid diseases. | Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases.
Bossowski A, Czarnocka B, Bardadin K, Moniuszko A, Łyczkowska A, Czerwinska J, Dadan J, Bossowska A. | 11/13/2010 |
| SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR) and has a role in impaired post-transcriptional regulation of vascular endothelial growth factor | Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor.
Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH., Free PMC Article | 01/21/2010 |
| TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2 | TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.
Yeowell HN, Walker LC, Mauger DM, Seth P, Garcia-Blanco MA. | 01/21/2010 |
| Simultaneous knockdown of TIA1 and TIAL1 resulted in increased skipping of alternatively spliced exons associated with U-rich motifs, but did not affect alternatively spliced exons that are not associated with U-rich motifs. | A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.
Aznarez I, Barash Y, Shai O, He D, Zielenski J, Tsui LC, Parkinson J, Frey BJ, Rommens JM, Blencowe BJ., Free PMC Article | 01/21/2010 |
| Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. | Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation.
Liao B, Hu Y, Brewer G. | 01/21/2010 |
| In contrast with previous assumptions, the mutated residues are buried within the hydrophobic interior of the domain, where they would be likely to destabilize the RRM fold rather than directly inhibit RNA binding. | Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.
Kumar AO, Swenson MC, Benning MM, Kielkopf CL., Free PMC Article | 01/21/2010 |
| Results report the identification of a C-rich signature motif present in TIAR target mRNAs whose association with TIAR decreases following exposure to a stress-causing agent. | Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.
Kim HS, Kuwano Y, Zhan M, Pullmann R Jr, Mazan-Mamczarz K, Li H, Kedersha N, Anderson P, Wilce MC, Gorospe M, Wilce JA., Free PMC Article | 01/21/2010 |
| Show increased TIA-1 positive cytotoxic T-lymphocytes in inflamed mucosa of patients with inflammatory bowel disease. | Contribution of TIA-1+ and granzyme B+ cytotoxic T lymphocytes to cryptal apoptosis and ulceration in active inflammatory bowel disease.
Mitomi H, Ohkura Y, Yokoyama K, Sada M, Kobayashi K, Tanabe S, Fukui N, Kanazawa H, Kishimoto I, Saigenji K. | 01/21/2010 |
| TIAR regulates the relative expression of TIA-1 isoforms. | Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.
Izquierdo JM, Valcárcel J. | 01/21/2010 |
| HuR, KSRP and TIAR are bound to one or more loci in the 3'UTR of IL-8 in breast cancer cells. | IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR.
Suswam EA, Nabors LB, Huang Y, Yang X, King PH. | 01/21/2010 |
| activated during HSV-1 infection and accumulated in cytoplasm of cells 6 hr after infection | Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.
Esclatine A, Taddeo B, Roizman B., Free PMC Article | 01/21/2010 |