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    TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens (human) ]

    Gene ID: 7078, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    miR-21 Exerts Anti-proliferative and Pro-apoptotic Effects in LPS-induced WI-38 Cells via Directly Targeting TIMP3.

    miR-21 Exerts Anti-proliferative and Pro-apoptotic Effects in LPS-induced WI-38 Cells via Directly Targeting TIMP3.
    Li JX, Li Y, Xia T, Rong FY.

    08/28/2024
    Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.

    Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
    Bi X, Lou P, Song Y, Sheng X, Liu R, Deng M, Yang X, Li G, Yuan S, Zhang H, Jiao B, Zhang B, Xue L, Liu Z, Plikus MV, Ren F, Gao S, Zhao L, Yu Z.

    08/26/2024
    Associations between genetically predicted TIMP-3 levels and risk of venous thromboembolism: A two sample Mendelian randomization study.

    Associations between genetically predicted TIMP-3 levels and risk of venous thromboembolism: A two sample Mendelian randomization study.
    Li Y, Wang X, Zhang X, Chen Q, Shi X, Zhang B, Xu J, Han B.

    08/19/2024
    Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas.

    Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas.
    Yang Y, Huang F, Wu X, Huang C, Li Y.

    06/3/2024
    Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification.

    Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification.
    Gao D, Zhao Q, Liu C, Zhang Y, Xiao L.

    05/31/2024
    Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation.

    Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation.
    Vergaro A, Pankievic M, Jedlickova J, Dudakova L, Vajter M, Michaelides M, Meliska M, Nemec P, Babincova D, Kousal B, Liskova P., Free PMC Article

    05/21/2024
    Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy.

    Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy.
    Betts JHJ, Troeberg L., Free PMC Article

    04/18/2024
    TIMP3/Wnt axis regulates gliosis of Muller glia.

    TIMP3/Wnt axis regulates gliosis of Müller glia.
    Hung JH, Tsai PH, Aala WJF, Chen CC, Chiou SH, Wong TW, Tsai KJ, Hsu SM, Wu LW.

    04/16/2024
    Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm.

    Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm.
    Hu M, Meganathan I, Zhu J, MacArthur R, Kassiri Z.

    12/15/2023
    Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer.

    Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer.
    Zhou Y, Zhang T, Wang S, Yang R, Jiao Z, Lu K, Li H, Jiang W, Zhang X.

    08/25/2023
    Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia.

    Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia.
    Palei AC, Cruz JO, Chaguri JL, Peraçoli JC, Romão-Veiga M, Ribeiro-Vasques VR, Cavalli RC, Nunes PR, Luizon MR, Sandrim VC., Free PMC Article

    04/20/2023
    Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis.

    Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis.
    Tayman MA, Koyuncu İ.

    02/11/2023
    Impact of Clinicopathological Characteristics and Tissue Inhibitor of Metalloproteinase-3 Polymorphism Rs9619311 on Biochemical Recurrence in Taiwanese Patients with Prostate Cancer.

    Impact of Clinicopathological Characteristics and Tissue Inhibitor of Metalloproteinase-3 Polymorphism Rs9619311 on Biochemical Recurrence in Taiwanese Patients with Prostate Cancer.
    Hsieh CY, Lin CY, Wang SS, Chou YE, Chien MH, Wen YC, Hsieh MJ, Yang SF., Free PMC Article

    01/21/2023
    TIMP3 Gene Polymorphisms of -1296 T > C and -915 A > G Increase the Susceptibility to Arsenic-Induced Skin Cancer: A Cohort Study and In Silico Analysis of Mutation Impacts.

    TIMP3 Gene Polymorphisms of -1296 T > C and -915 A > G Increase the Susceptibility to Arsenic-Induced Skin Cancer: A Cohort Study and In Silico Analysis of Mutation Impacts.
    Wu MM, Chen CW, Chen CY, Lee CH, Chou M, Hsu LI, Lee TC, Chen CJ., Free PMC Article

    12/31/2022
    Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis.

    Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis.
    Chang RM, Fu Y, Zeng J, Zhu XY, Gao Y., Free PMC Article

    12/31/2022
    Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy.

    Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy.
    Qi JH, Anand-Apte B., Free PMC Article

    12/10/2022
    CircRNA-001241 mediates sorafenib resistance of hepatocellular carcinoma cells by sponging miR-21-5p and regulating TIMP3 expression.

    CircRNA-001241 mediates sorafenib resistance of hepatocellular carcinoma cells by sponging miR-21-5p and regulating TIMP3 expression.
    Yang Q, Wu G.

    12/3/2022
    Early-Onset TIMP3-Related Retinopathy Associated With Impaired Signal Peptide.

    Early-Onset TIMP3-Related Retinopathy Associated With Impaired Signal Peptide.
    Guan B, Huryn LA, Hughes AB, Li Z, Bender C, Blain D, Turriff A, Cukras CA, Hufnagel RB., Free PMC Article

    07/30/2022
    Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan.

    Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan.
    Chung JF, Chen CL, Nassef Y, Shiu BH, Wang CH, Kuo FH, Hsiao YH, Yang SF, Wang PH., Free PMC Article

    07/23/2022
    Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy.

    Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy.
    Liu Q, Liu C, Dong Y, Li H, Ren J.

    06/11/2022
    Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3-mediated RhoA/ROCK pathway in the ischemic liver.

    Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3-mediated RhoA/ROCK pathway in the ischemic liver.
    Rao J, Qiu J, Ni M, Wang H, Wang P, Zhang L, Wang Z, Liu M, Cheng F, Wang X, Lu L., Free PMC Article

    05/28/2022
    The tumor suppressive role of TIMP3 in the human osteosarcoma cells.

    The tumor suppressive role of TIMP3 in the human osteosarcoma cells.
    Tan B, Xu X, Zhang Q, Yuan Z, Dong J.

    05/28/2022
    Comprehensive analyses of DNA methylation of the TIMP3 promoter in placentas from early-onset and late-onset preeclampsia.

    Comprehensive analyses of DNA methylation of the TIMP3 promoter in placentas from early-onset and late-onset preeclampsia.
    Cruz JO, Conceição IMCA, Sandrim VC, Luizon MR.

    03/12/2022
    MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease.

    MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease.
    Liu C, Yang D, Wang H, Hu S, Xie X, Zhang L, Jia H, Qi Q.

    02/19/2022
    Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis.

    Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis.
    Gao Y, Zou T, Liang W, Zhang Z, Qie M.

    02/12/2022
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