| Blood oxygen regulation via P2Y12R expressed in the carotid body. | Blood oxygen regulation via P2Y12R expressed in the carotid body.
Iring A, Baranyi M, Iring-Varga B, Mut-Arbona P, Gál ZT, Nagy D, Hricisák L, Varga J, Benyó Z, Sperlágh B., Free PMC Article | 06/21/2024 |
| A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies. | A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies.
Uweru OJ, Okojie AK, Trivedi A, Benderoth J, Thomas LS, Davidson G, Cox K, Eyo UB., Free PMC Article | 04/22/2024 |
| APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Abeta, through P2RY12. | APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12.
Sepulveda J, Kim JY, Binder J, Vicini S, Rebeck GW., Free PMC Article | 03/14/2024 |
| Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells. | Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Zhuang W, Liu X, Liu G, Lv J, Qin H, Wang C, Xie L, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Du C., Free PMC Article | 08/3/2023 |
| Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. | Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences.
Bollinger JL, Dadosky DT, Flurer JK, Rainer IL, Woodburn SC, Wohleb ES., Free PMC Article | 07/21/2023 |
| D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function. | D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function.
Dangelmaier C, Mauri B, Patel A, Kunapuli SP, Kostyak JC., Free PMC Article | 10/22/2022 |
| Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD. | Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
Ma C, Fu Q, Diggs LP, McVey JC, McCallen J, Wabitsch S, Ruf B, Brown Z, Heinrich B, Zhang Q, Rosato U, Wang S, Cui L, Berzofsky JA, Kleiner DE, Bosco DB, Wu LJ, Lai CW, Rotman Y, Xie C, Korangy F, Greten TF., Free PMC Article | 10/1/2022 |
| The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets. | The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets.
Iring A, Tóth A, Baranyi M, Otrokocsi L, Módis LV, Gölöncsér F, Varga B, Hortobágyi T, Bereczki D, Dénes Á, Sperlágh B. | 03/26/2022 |
| P2Y12 Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction. | P2Y(12) Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction.
Schmidt SN, Reichardt W, Kaufmann BA, Wadle C, von Elverfeldt D, Stachon P, Hilgendorf I, Wolf D, Heidt T, Duerschmied D, Peter K, Bode C, von Zur Mühlen C, Maier A., Free PMC Article | 01/8/2022 |
| The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis. | The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C, Liu J, Dang Y, Xia Y, He Q, Jin H, Li Y, Hu Y, Miao Y, Yue Z, Hu B., Free PMC Article | 11/27/2021 |
| C3G contributes to platelet activation and aggregation by regulating major signaling pathways. | C3G contributes to platelet activation and aggregation by regulating major signaling pathways.
Gutiérrez-Herrero S, Fernández-Infante C, Hernández-Cano L, Ortiz-Rivero S, Guijas C, Martín-Granado V, González-Porras JR, Balsinde J, Porras A, Guerrero C., Free PMC Article | 10/16/2021 |
| Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. | Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice.
Bisht K, Okojie KA, Sharma K, Lentferink DH, Sun YY, Chen HR, Uweru JO, Amancherla S, Calcuttawala Z, Campos-Salazar AB, Corliss B, Jabbour L, Benderoth J, Friestad B, Mills WA 3rd, Isakson BE, Tremblay MÈ, Kuan CY, Eyo UB., Free PMC Article | 10/9/2021 |
| Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in precapillary pulmonary arterioles. | Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in precapillary pulmonary arterioles.
Brzoska T, Vats R, Bennewitz MF, Tutuncuoglu E, Watkins SC, Ragni MV, Neal MD, Gladwin MT, Sundd P., Free PMC Article | 05/22/2021 |
| Loss of P2Y12 Has Behavioral Effects in the Adult Mouse. | Loss of P2Y12 Has Behavioral Effects in the Adult Mouse.
Lowery RL, Mendes MS, Sanders BT, Murphy AJ, Whitelaw BS, Lamantia CE, Majewska AK., Free PMC Article | 04/17/2021 |
| Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. | Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype.
Pavlović N, Kopsida M, Gerwins P, Heindryckx F., Free PMC Article | 03/20/2021 |
| Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function. | Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function.
Hao Y, Wang L, Chen H, Hill WG, Robson SC, Zeidel ML, Yu W., Free PMC Article | 09/19/2020 |
| Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. | Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome.
Diaz-Aparicio I, Paris I, Sierra-Torre V, Plaza-Zabala A, Rodríguez-Iglesias N, Márquez-Ropero M, Beccari S, Huguet P, Abiega O, Alberdi E, Matute C, Bernales I, Schulz A, Otrokocsi L, Sperlagh B, Happonen KE, Lemke G, Maletic-Savatic M, Valero J, Sierra A., Free PMC Article | 08/22/2020 |
| Extracellular ADP acts on the P2Y12 receptor. | Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor.
Suzuki T, Kohyama K, Moriyama K, Ozaki M, Hasegawa S, Ueno T, Saitoe M, Morio T, Hayashi M, Sakuma H. | 07/18/2020 |
| Microglial P2Y12 receptors promote both aberrant neurogenesis and increased immature neuronal projections. | Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections.
Mo M, Eyo UB, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P, Wu LJ., Free PMC Article | 07/4/2020 |
| microglial P2Y12R regulates neuronal excitability and innate fear behaviors in developing and adult mice. | Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice.
Peng J, Liu Y, Umpierre AD, Xie M, Tian DS, Richardson JR, Wu LJ., Free PMC Article | 06/6/2020 |
| a critical role for microglial P2Y12Rs in regulating the microglial landscape through cellular translocation independent of proliferation. These findings suggest that microglial patrol the CNS through both process motility and soma translocation. | P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape.
Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis DJ, Xu P, Wu LJ., Free PMC Article | 10/5/2019 |
| P2Y12 knockout mice exhibited anxiety-like behavior , memory deficit and impaired noradrenergic system in brain. | P2Y(12) deficiency in mouse impairs noradrenergic system in brain, and alters anxiety-like neurobehavior and memory.
Zheng F, Zhou Q, Cao Y, Shi H, Wu H, Zhang B, Huang F, Wu X. | 03/23/2019 |
| OC formation was efficiently restored by addition of adenosine diphosphate, a P2Y12 agonist, as well as by addition of CysLT. Furthermore, similar to montelukast, P2Y12 blockade by a pharmacological inhibitor or siRNAs suppressed OC differentiation | Montelukast inhibits RANKL‑induced osteoclast formation and bone loss via CysLTR1 and P2Y12.
Kang JH, Lim H, Lee DS, Yim M. | 11/3/2018 |
| Our finding demonstrated that genetic deletion of P2Y12 receptor broke the balance of Th subtypes by affecting the cytokine profile of bone marrow-derived dendritic cells and resulted in the aggravated experimental autoimmune encephalomyelitis, which suggested that P2Y12 may be a potential target in treating multiple sclerosis. | Knockout of P2Y(12) aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells.
Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S, Jiang W. | 09/1/2018 |
| Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability. | A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets.
Makkawi M, Howells D, Wright MD, Jackson DE. | 08/18/2018 |