| TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma. | TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma.
Geng L, Zhu M, Luo D, Chen H, Li B, Lao Y, An H, Wu Y, Li Y, Xia A, Shi Y, Tong Z, Lu S, Xu D, Wang X, Zhang W, Sun B, Xu Z., Free PMC Article | 02/28/2024 |
| Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation. | Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation.
Li M, Zhao X, Yong H, Xu J, Qu P, Qiao S, Hou P, Li Z, Chu S, Zheng J, Bai J., Free PMC Article | 03/26/2022 |
| QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle. | QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle.
Nauton L, Hecquet L, Théry V. | 08/14/2021 |
| Untargeted metabolomics as an unbiased approach to the diagnosis of inborn errors of metabolism of the non-oxidative branch of the pentose phosphate pathway. | Untargeted metabolomics as an unbiased approach to the diagnosis of inborn errors of metabolism of the non-oxidative branch of the pentose phosphate pathway.
Shayota BJ, Donti TR, Xiao J, Gijavanekar C, Kennedy AD, Hubert L, Rodan L, Vanderpluym C, Nowak C, Bjornsson HT, Ganetzky R, Berry GT, Pappan KL, Sutton VR, Sun Q, Elsea SH., Free PMC Article | 07/3/2021 |
| The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines. | The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines.
Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J, Tong X, Bai J., Free PMC Article | 01/16/2021 |
| Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival. | Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.
Gu N, Dai W, Liu H, Ge J, Luo S, Cho E, Amos CI, Lee JE, Li X, Nan H, Yuan H, Wei Q., Free PMC Article | 01/9/2021 |
| Erythrocyte transketolase deficiency in patients suffering from Crohn's disease. | Erythrocyte transketolase deficiency in patients suffering from Crohn's disease.
Mańkowska-Wierzbicka D, Michalak S, Karczewski J, Dobrowolska A, Wierzbicka A, Stelmach-Mardas M. | 12/19/2020 |
| Transketolase Activity in the Formation of the Azinomycin Azabicycle Moiety | Transketolase Activity in the Formation of the Azinomycin Azabicycle Moiety.
Washburn LA, Foley B, Martinez F, Lee RP, Pryor K, Rimes E, Watanabe CMH. | 06/27/2020 |
| The regulation of TKT by oxythiamine and/or vitamin B1 may therefore be associated with response to the modulation of NET formation by preventing generation of excessive NETs in inflammatory diseases. | Transketolase and vitamin B1 influence on ROS-dependent neutrophil extracellular traps (NETs) formation.
Riyapa D, Rinchai D, Muangsombut V, Wuttinontananchai C, Toufiq M, Chaussabel D, Ato M, Blackwell JM, Korbsrisate S., Free PMC Article | 03/7/2020 |
| results suggest that SH2D5 is an HBV-induced protein capable of binding to TKT, leading to induction of HCC cell proliferation. | Hepatitis B virus X protein-induced SH2 domain-containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5-transketolase interaction.
Zheng Y, Ming P, Zhu C, Si Y, Xu S, Chen A, Wang J, Zhang B., Free PMC Article | 10/19/2019 |
| Over-expressed and hypo-methylated TKT gene is associated with hepatocellular carcinoma. | Genome-wide DNA methylation analysis identifies candidate epigenetic markers and drivers of hepatocellular carcinoma.
Zheng Y, Huang Q, Ding Z, Liu T, Xue C, Sang X, Gu J. | 10/27/2018 |
| The observed associations of genetic variation in transketolase enzyme with neuropathic symptoms and reduced thermal sensation in recent-onset diabetes suggest a role of pathways metabolizing glycolytic intermediates in early diabetic neuropathy. | Association of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes.
Ziegler D, Schleicher E, Strom A, Knebel B, Fleming T, Nawroth P, Häring HU, Papanas N, Szendrödi J, Müssig K, Al-Hasani H, Roden M, GDS Group. | 03/10/2018 |
| reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients | Proteomics reveals reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients.
Barasa BA, van Oirschot BA, Bianchi P, van Solinge WW, Heck AJ, van Wijk R, Slijper M. | 09/16/2017 |
| Mutations in TKT gene is associated with a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects. | Mutations in TKT Are the Cause of a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects.
Boyle L, Wamelink MMC, Salomons GS, Roos B, Pop A, Dauber A, Hwa V, Andrew M, Douglas J, Feingold M, Kramer N, Saitta S, Retterer K, Cho MT, Begtrup A, Monaghan KG, Wynn J, Chung WK., Free PMC Article | 05/13/2017 |
| transketolase (TKT)is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. | Transketolase counteracts oxidative stress to drive cancer development.
Xu IM, Lai RK, Lin SH, Tse AP, Chiu DK, Koh HY, Law CT, Wong CM, Cai Z, Wong CC, Ng IO., Free PMC Article | 07/16/2016 |
| Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation. | Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.
Ricciardelli C, Lokman NA, Cheruvu S, Tan IA, Ween MP, Pyragius CE, Ruszkiewicz A, Hoffmann P, Oehler MK. | 08/29/2015 |
| Akt1 phosphorylates TKT on Thr382, markedly enhancing enzyme activity. | Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis.
Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR., Free PMC Article | 10/18/2014 |
| TKT rs3736156 identified significant differences in the onset of cardiovascular event in patients having genotypes AG + AA versus GG | Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality.
Tanhäuserová V, Kuricová K, Pácal L, Bartáková V, Rehořová J, Svojanovský J, Olšovský J, Bělobrádková J, Kaňková K. | 08/9/2014 |
| basal TK activity was decreased in cases with diabetic neuropathy | Erythrocyte transketolase activity in patients with diabetic and alcoholic neuropathies.
Michalak S, Michałowska-Wender G, Adamcewicz G, Wender MB. | 03/22/2014 |
| Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme. | Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Fullam E, Pojer F, Bergfors T, Jones TA, Cole ST., Free PMC Article | 06/22/2013 |
| Data indicate that transketolase (hTKT). shares 61% sequence identity with transketolase-like protein (TKTL1). | Is transketolase-like protein, TKTL1, transketolase?
Meshalkina LE, Drutsa VL, Koroleva ON, Solovjeva ON, Kochetov GA. | 05/11/2013 |
| No transketolase activity of TKTDelta38 can be detected for conversion of physiological sugar substrates thus arguing against an intrinsically encoded enzymatic function of TKTL1 in tumor cell metabolism | A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity.
Schneider S, Lüdtke S, Schröder-Tittmann K, Wechsler C, Meyer D, Tittmann K., Free PMC Article | 04/13/2013 |
| Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy. | Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
Pácal L, Tomandl J, Svojanovsky J, Krusová D, Stepánková S, Rehorová J, Olsovsky J, Belobrádková J, Tanhäuserová V, Tomandlová M, Muzík J, Kanková K. | 09/10/2011 |
| TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| The crystal structure of human transketolase and new insights into its mode of action. | The crystal structure of human transketolase and new insights into its mode of action.
Mitschke L, Parthier C, Schröder-Tittmann K, Coy J, Lüdtke S, Tittmann K., Free PMC Article | 11/6/2010 |