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    TLR2 toll like receptor 2 [ Homo sapiens (human) ]

    Gene ID: 7097, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TLR2 reprograms glucose metabolism in CD4[+] T cells of rheumatoid arthritis patients to mediate cell hyperactivation and TNF-alpha secretion.

    TLR2 reprograms glucose metabolism in CD4(+) T cells of rheumatoid arthritis patients to mediate cell hyperactivation and TNF-α secretion.
    Lin Q, Zhang C, Huang H, Bai Z, Liu J, Zhang Y, Li X, Wang G.

    10/22/2024
    TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells.

    TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells.
    Landolina N, Ricci B, Veneziani I, Alicata C, Mariotti FR, Pelosi A, Quatrini L, Mortari EP, Carsetti R, Vacca P, Tumino N, Azzarone B, Moretta L, Maggi E., Free PMC Article

    10/18/2024
    Association between Toll-like receptor 2 rs4696483 and rs1898830 polymorphisms and the risk of triple-negative breast cancer.

    Association between Toll-like receptor 2 rs4696483 and rs1898830 polymorphisms and the risk of triple-negative breast cancer.
    Ghali RM, Zaied S, Daldoul A, Kanabekova P, Almawi WY.

    09/25/2024
    Salivary IL-33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis.

    Salivary IL-33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis.
    Yilmaz M, He Q, Demir E, Teräsjärvi J, Gürsoy UK.

    09/24/2024
    The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism.

    The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism.
    Pannone G, Pedicillo MC, De Stefano IS, Angelillis F, Barile R, Pannone C, Villani G, Miele F, Municinò M, Ronchi A, Serviddio G, Zito Marino F, Franco R, Colangelo T, Zamparese R., Free PMC Article

    09/10/2024
    Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-alpha-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor gamma and Suppression of NF-kappaB p65.

    Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65.
    Abdulqadir R, Al-Sadi R, Haque M, Gupta Y, Rawat M, Ma TY.,

    08/30/2024
    TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links with Vitreous Levels of Complement Fragments and DAMP-Related Proteins.

    TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links with Vitreous Levels of Complement Fragments and DAMP-Related Proteins.
    Dinice L, Esposito G, Cacciamani A, Balzamino BO, Cosimi P, Cafiero C, Ripandelli G, Micera A., Free PMC Article

    07/29/2024
    TLR2 and TLR4 Polymorphisms Are Not Associated with Dental Caries in Polish Children.

    TLR2 and TLR4 Polymorphisms Are Not Associated with Dental Caries in Polish Children.
    Milona M, Olszowski T, Uzar I, Safranow K, Janiszewska-Olszowska J, Szmidt-Kądys M, Rola H, Sikora M, Chlubek D, Adler G., Free PMC Article

    07/18/2024
    Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.

    Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.
    Emele RE, Salim MA, Polat F, Diler SB., Free PMC Article

    07/15/2024
    Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population.

    Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population.
    Ding X, Lin Q, Zhao J, Fu Y, Zheng Y, Mo R, Zhang L, Zhang B, Chen J, Xie T, Wu H, Ding Y.

    07/6/2024
    Identification of toll-like receptor 2 as a key regulator of neuronal apoptosis in vascular dementia by bioinformatics analysis and experimental validation.

    Identification of toll-like receptor 2 as a key regulator of neuronal apoptosis in vascular dementia by bioinformatics analysis and experimental validation.
    Yan B, Liao P, Cheng F, Wang C, Zhang J, Han Z, Liu Y, Zhang L, Zhang W, Li M, Li D, Chen F, Lei P.

    07/1/2024
    Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study.

    Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study.
    Karabatić Knezović S, Knezović D, Matana A, Puizina Ivić N, Drmić Hofman I., Free PMC Article

    06/27/2024
    Exploring the Impact of TLR-2 Signaling on miRNA Dysregulation in Intervertebral Disc Degeneration.

    Exploring the Impact of TLR-2 Signaling on miRNA Dysregulation in Intervertebral Disc Degeneration.
    Cazzanelli P, Lamoca M, Hausmann ON, Mesfin A, Puvanesarajah V, Hitzl W, Haglund L, Wuertz-Kozak K.

    05/31/2024
    TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne.

    TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne.
    Wei Z, Gao M, Liu Y, Zeng R, Liu J, Sun S, Li S, Hu L, Xiang R, Mo R, Song Z, Chen Z, Bao D, Hua D, Zouboulis CC, Feng Y, Li J, Yang Y.

    05/29/2024
    Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.

    Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.
    Ayari F, Chaaben AB, Abaza H, Mihoub O, Ouni N, Boukouaci W, Kharrat M, Leboyer M, Guemira F, Tamouza R, Mankai A.

    04/4/2024
    Expression of TLR2, IL-1beta, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians.

    Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians.
    Lukyanova SO, Artemyeva OV, Strazhesko ID, Nasaeva ED, Grechenko VV, Gankovskaya LV.

    03/31/2024
    p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.

    p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
    Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E.

    03/29/2024
    Association between polymorphisms of TLR2-1-6 and bipolar disorder in a tunisian population.

    Association between polymorphisms of TLR2-1-6 and bipolar disorder in a tunisian population.
    Aflouk Y, Inoubli O, Kenz A, Yacoub S, Zaafrane F, Gaha L, Bel Hadj Jrad B.

    03/20/2024
    Human Toll-like receptor 2 genetic polymorphisms with tuberculosis susceptibility: A systematic review and meta-analysis.

    Human Toll-like receptor 2 genetic polymorphisms with tuberculosis susceptibility: A systematic review and meta-analysis.
    Chen R, Wang X, Li Z, Dai Y, Du W, Wu L.

    03/15/2024
    Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer.

    Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer.
    Wang Y, Wang G, Wang X, Yang J, Shen Y, Zhao B, Yang J.

    03/4/2024
    P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9.

    P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9.
    Pandi K, Angabo S, Makkawi H, Benyamini H, Elgavish S, Nussbaum G.

    02/28/2024
    miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-kappaB signaling pathway.

    miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.
    Yao M, Fang C, Wang Z, Guo T, Wu D, Ma J, Wu J, Mo J., Free PMC Article

    02/26/2024
    Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.

    Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
    Shen C, Wang H.

    02/23/2024
    Correlation of polymorphism in Toll-Like Receptor (TLR1 and TLR2) genes with susceptibility of pulmonary tuberculosis in Doda region of India.

    Correlation of polymorphism in Toll-Like Receptor (TLR1 and TLR2) genes with susceptibility of pulmonary tuberculosis in Doda region of India.
    Zargar AS, Borole K, Rai R.

    02/20/2024
    Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1.

    Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1.
    Kim HY, Lim Y, Jang JS, Ko YK, Choi Y, Kim HH, Choi BK., Free PMC Article

    02/16/2024
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