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    TNFAIP3 TNF alpha induced protein 3 [ Homo sapiens (human) ]

    Gene ID: 7128, updated on 16-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-kappaB Signaling Pathway.

    Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-κB Signaling Pathway.
    Zhang H, Shi Z, Guo Y, Wu D, Yu G, Xu J.

    04/11/2024
    Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients.

    Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients.
    Wang K, Si T, Wei C, Hu Q, Zhou Y, Bao J.

    03/25/2024
    The Complexity of Being A20: From Biological Functions to Genetic Associations.

    The Complexity of Being A20: From Biological Functions to Genetic Associations.
    Karri U, Harasimowicz M, Carpio Tumba M, Schwartz DM.

    03/14/2024
    The functional TNFAIP3 rs2230926T/G (Phe127Cys) variant confers risk to systemic lupus erythematosus in a Latin American population.

    The functional TNFAIP3 rs2230926T/G (Phe127Cys) variant confers risk to systemic lupus erythematosus in a Latin American population.
    Montúfar-Robles I, Barbosa-Cobos RE, Romero-Díaz J, Valencia-Pacheco G, Cabello-Gutiérrez C, Ramírez-Bello J.

    02/2/2024
    Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-kappaB Activation in Lupus Nephritis.

    Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis.
    Zou L, Sun L, Hua R, Wu Y, Sun L, Chen T., Free PMC Article

    01/4/2024
    METTL14-Mediated m6A Modification of TNFAIP3 Involved in Inflammation in Patients With Active Rheumatoid Arthritis.

    METTL14-Mediated m6A Modification of TNFAIP3 Involved in Inflammation in Patients With Active Rheumatoid Arthritis.
    Tang J, Yu Z, Xia J, Jiang R, Chen S, Ye D, Sheng H, Lin J.

    11/30/2023
    Association between PYTPN22 rs2476601, VEGF rs833070, TNFAIP3 rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study.

    Association between PYTPN22 rs2476601, VEGF rs833070, TNFAIP3 rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study.
    Sakalyte R, Stropuviene S, Jasionyte G, Bagdonaite L, Venalis A., Free PMC Article

    11/2/2023
    Human osteoarthritic articular cartilage stem cells suppress osteoclasts and improve subchondral bone remodeling in experimental knee osteoarthritis partially by releasing TNFAIP3.

    Human osteoarthritic articular cartilage stem cells suppress osteoclasts and improve subchondral bone remodeling in experimental knee osteoarthritis partially by releasing TNFAIP3.
    Li ZL, Li XT, Hao RC, Wang FY, Wang YX, Zhao ZD, Li PL, Yin BF, Mao N, Ding L, Zhu H., Free PMC Article

    09/28/2023
    A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block "eat-me" signal.

    A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block "eat-me" signal.
    Luo M, Wang X, Wu S, Yang C, Su Q, Huang L, Fu K, An S, Xie F, To KKW, Wang F, Fu L., Free PMC Article

    08/30/2023
    The Prevalence of MYD88 L265P and TNFAIP3 Mutations and Their Correlations with Clinico-Hematological Profile in Egyptian Patients with Diffuse Large B Cell Lymphoma.

    The Prevalence of MYD88 L265P and TNFAIP3 Mutations and Their Correlations with Clinico-Hematological Profile in Egyptian Patients with Diffuse Large B Cell Lymphoma.
    Elbaz O, Shaat RM, Abd El Ghaffar HA, Shamaa S, Abdel-Masseih HM, Anber N, Mortada MI., Free PMC Article

    08/2/2023
    A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation.

    A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation.
    El Khouri E, Diab F, Louvrier C, Assrawi E, Daskalopoulou A, Nguyen A, Piterboth W, Deshayes S, Desdoits A, Copin B, Dastot Le Moal F, Karabina SA, Amselem S, Aouba A, Giurgea I., Free PMC Article

    06/26/2023
    The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-kappaB activation in acute kidney injury.

    The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury.
    Rogers NM, Zammit N, Nguyen-Ngo D, Souilmi Y, Minhas N, Meijles DN, Self E, Walters SN, Warren J, Cultrone D, El-Rashid M, Li J, Chtanova T, O'Connell PJ, Grey ST.

    05/22/2023
    Tumor necrosis factor alpha-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson's disease via the NFkappaB and mTOR pathways.

    Tumor necrosis factor α-induced protein 3 mediates inflammation and neuronal autophagy in Parkinson's disease via the NFκB and mTOR pathways.
    Ma C, Wei X, Wang F, Zhang T, Jiang Y, Meng Z, Zhang Z.

    04/26/2023
    A20 and the noncanonical NF-kappaB pathway are key regulators of neutrophil recruitment during fetal ontogeny.

    A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.
    Rohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M., Free PMC Article

    03/16/2023
    TNFAIP3 mutation is an independent poor overall survival factor for patients with T-cell acute lymphoblastic leukemia.

    TNFAIP3 mutation is an independent poor overall survival factor for patients with T-cell acute lymphoblastic leukemia.
    Chen C, Zhou L, Zhu L, Luo G, Wang L, Zeng C, Zhou H, Li Y., Free PMC Article

    03/2/2023
    A20 functions as a negative regulator of the lipopolysaccharide-induced inflammation in corneal epithelial cells.

    A20 functions as a negative regulator of the lipopolysaccharide-induced inflammation in corneal epithelial cells.
    Yu Y, Li K, Xue R, Liu S, Liu X, Wu K.

    03/2/2023
    No association of eight TNFAIP3 single nucleotide variants to rheumatoid arthritis in Mexicans.

    No association of eight TNFAIP3 single nucleotide variants to rheumatoid arthritis in Mexicans.
    Aranda-Uribe IS, Ramírez-Bello J, Victoria-Acosta G, Muñoz-González F, Barbosa-Cobos RE, Moreno J.

    11/5/2022
    TNFAIP3 mutation causing haploinsufficiency of A20 with a hemophagocytic lymphohistiocytosis phenotype: a report of two cases.

    TNFAIP3 mutation causing haploinsufficiency of A20 with a hemophagocytic lymphohistiocytosis phenotype: a report of two cases.
    Aslani N, Asnaashari K, Parvaneh N, Shahrooei M, Sotoudeh-Anvari M, Shahram F, Ziaee V., Free PMC Article

    10/22/2022
    Lack of association between the TNFAIP3 rs2230926 variant and rheumatoid arthritis-associated lymphoma.

    Lack of association between the TNFAIP3 rs2230926 variant and rheumatoid arthritis-associated lymphoma.
    Kedra J, Seror R, Dieudé P, Constantin A, Toussirot E, Kfoury E, Masson C, Cornec D, Dubost JJ, Marguerie L, Ottaviani S, Grados F, Belkhir R, Fain O, Fautrel B, Philippe P, Piperno M, Combe B, Lambotte O, Richez C, Sellam J, Sené T, Denis G, Lequerre T, Lazure T, Mariette X, Nocturne G.

    10/15/2022
    TNFAIP3 promotes ALDH-positive breast cancer stem cells through FGFR1/MEK/ERK pathway.

    TNFAIP3 promotes ALDH-positive breast cancer stem cells through FGFR1/MEK/ERK pathway.
    Feng W, Gao M, Yang M, Li X, Gan Z, Wu T, Lin Y, He T.

    10/8/2022
    GSTO1 confers drug resistance in HCT116 colon cancer cells through an interaction with TNFalphaIP3/A20.

    GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20.
    Paul S, Bhardwaj M, Kang SC., Free PMC Article

    09/24/2022
    USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.

    USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.
    Jantaree P, Chaithongyot S, Sokolova O, Naumann M., Free PMC Article

    08/6/2022
    Clinicopathologic Characteristics and A20 Mutation in Primary Thyroid Lymphoma.

    Clinicopathologic Characteristics and A20 Mutation in Primary Thyroid Lymphoma.
    Kuribayashi-Hamada Y, Ishibashi M, Tatsuguchi A, Asayama T, Takada-Okuyama N, Onodera-Kondo A, Moriya K, Igarashi T, Onose H, Tanosaki S, Yokose N, Yamaguchi H, Tamura H.

    07/9/2022
    Identification of a Novel Mutation in TNFAIP3 in a Family With Poly-Autoimmunity.

    Identification of a Novel Mutation in TNFAIP3 in a Family With Poly-Autoimmunity.
    Rossi MN, Federici S, Uva A, Passarelli C, Celani C, Caiello I, Matteo V, Petrocchi S, Mortari EP, De Benedetti F, Prencipe G, Insalaco A., Free PMC Article

    05/14/2022
    TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation.

    TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation.
    Zammit NW, McDowell J, Warren J, Muskovic W, Gamble J, Shi YC, Kaczorowski D, Chan CL, Powell J, Ormandy C, Brown D, Oakes SR, Grey ST., Free PMC Article

    04/30/2022
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