| Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis. | Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.
Hu Y, Yu Y, Dong H, Jiang W., Free PMC Article | 06/3/2023 |
| C1QA, C1QB, and GZMB are novel prognostic biomarkers of skin cutaneous melanoma relating tumor microenvironment. | C1QA, C1QB, and GZMB are novel prognostic biomarkers of skin cutaneous melanoma relating tumor microenvironment.
Liang Z, Pan L, Shi J, Zhang L., Free PMC Article | 12/10/2022 |
| Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids. | Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids.
Rupprecht R, Rupprecht C, Di Benedetto B, Rammes G. | 11/5/2022 |
| Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology. | Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology.
Jiao Y, Jiang S, Wang Y, Yu T, Zou G, Zhuo L, Li W., Free PMC Article | 05/21/2022 |
| C1q-binding DSA and allograft outcomes in pediatric kidney transplant recipients. | C1q-binding DSA and allograft outcomes in pediatric kidney transplant recipients.
Hayde N, Solomon S, Caglar E, Ge J, Qama E, Colovai A. | 01/8/2022 |
| Clinical and prognostic significance of C1q deposition in IgAN patients-a retrospective study. | Clinical and prognostic significance of C1q deposition in IgAN patients-a retrospective study.
Tian S, Yang X, Luo J, Guo H. | 05/29/2021 |
| C1Q polymorphisms are associated with systemic lupus erythematosus. | Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance.
Guo J, Gao Y, Wang Y, Zou Y, Du Y, Luo C, Shi Y, Yang Y, Wu X, Su Y, Wu L, Chen S, Li Z., Free PMC Article | 11/30/2019 |
| results suggested that four differentially expressed genes, Jun, Gal, Cd74, and C1qb, had the potential to serve as prognostic or predictive markers for neuropathic pain, suggesting a potential application in the improvement of prognostic tools and treatments. | Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.
Yang JA, He JM, Lu JM, Jie LJ. | 03/2/2019 |
| The C allele at the rs631090 locus of C1q, the G allele at 1525A/G site of TRAIL, and the G allele of Tim-1 at -1454G/A site are susceptibility variants associated with SLE. the frequency of the T allele at the rs631090 locus in the study group was lower than that in the controls, and the frequency of the C allele was higher in the study group than in the healthy donors. | Association Between C1q, TRAIL, and Tim-1 Gene Polymorphisms and Systemic Lupus Erythematosus.
Yu Y, Zhu C, Zhou S, Chi S. | 01/5/2019 |
| C1QB expression is significantly upregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| no significant association found to either rs15940 (C1QA) or rs172378 (C1QC) when analysed in just Parkinson disease cases , just controls or combined | Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease.
Carbutt S, Duff J, Yarnall A, Burn DJ, Hudson G., Free PMC Article | 09/26/2015 |
| PepO facilitates C1q-mediated bacterial adherence, whereas its localized release consumes complement as a result of its activation following binding of C1q, thus representing an additional mechanism of human complement escape by this versatile pathogen. | Binding of Streptococcus pneumoniae endopeptidase O (PepO) to complement component C1q modulates the complement attack and promotes host cell adherence.
Agarwal V, Sroka M, Fulde M, Bergmann S, Riesbeck K, Blom AM., Free PMC Article | 10/11/2014 |
| Data indicate that Cna binds to C1q. | Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.
Kang M, Ko YP, Liang X, Ross CL, Liu Q, Murray BE, Höök M., Free PMC Article | 09/28/2013 |
| Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s-C1r-C1r-C1s tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 | Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.
Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, Schoehn G, Arlaud GJ, Thielens NM., Free PMC Article | 08/10/2013 |
| Single nucleotide polymorphisms in and around the C1q genes, C1qA, C1qB and C1qC, correlated with C1q serum levels and may be a risk for the development of rheumatoid arthritis. | Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.
Trouw LA, Daha N, Kurreeman FA, Böhringer S, Goulielmos GN, Westra HJ, Zhernakova A, Franke L, Stahl EA, Levarht EW, Stoeken-Rijsbergen G, Verduijn W, Roos A, Li Y, Houwing-Duistermaat JJ, Huizinga TW, Toes RE., Free PMC Article | 08/10/2013 |
| We identified a major linear epitope of C1q that is the target of anti-C1q in systemic lupus erythematosus. | Identification of a major linear C1q epitope allows detection of systemic lupus erythematosus anti-C1q antibodies by a specific peptide-based enzyme-linked immunosorbent assay.
Vanhecke D, Roumenina LT, Wan H, Osthoff M, Schaller M, Trendelenburg M. | 01/12/2013 |
| analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages | Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.
Chen G, Tan CS, Teh BK, Lu J., Free PMC Article | 12/10/2011 |
| The susceptibility for schizophrenia was particularly associated with C1QB rs291982 GG genotype. | Association of C1QB gene polymorphism with schizophrenia in Armenian population.
Zakharyan R, Khoyetsyan A, Arakelyan A, Boyajyan A, Gevorgyan A, Stahelova A, Mrazek F, Petrek M., Free PMC Article | 12/3/2011 |
| a 2-gene signature consisting of PLEK2 and C1QB led to the best result that correctly classified 93.3% melanoma patients and 90% healthy controls | Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma.
Luo Y, Robinson S, Fujita J, Siconolfi L, Magidson J, Edwards CK, Wassmann K, Storm K, Norris DA, Bankaitis-Davis D, Robinson WA, Fujita M., Free PMC Article | 11/12/2011 |
| In a large family-based association study of C1Q gene cluster polymorphisms no evidence for a genetic role of C1Q locus SNP in systemic lupus erythematosus risk predisposition was obtained in patients of European ancestry. | Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus.
Rafiq S, Frayling TM, Vyse TJ, Cunninghame Graham DS, Eggleton P, Rafiq S, Frayling TM, Vyse TJ, Cunninghame Graham DS, Eggleton P., Free PMC Articles: PMC2909410, PMC2909410 | 08/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that C1q, C4, C3, and C9 bind to thrombin receptor-activating peptide-activated platelets in lepirudin-anticoagulated platelet-rich plasma (PRP) and whole blood. | Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.
Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B., Free PMC Article | 05/10/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (8) articlesAssessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus.
Rafiq S, Frayling TM, Vyse TJ, Cunninghame Graham DS, Eggleton P, Rafiq S, Frayling TM, Vyse TJ, Cunninghame Graham DS, Eggleton P. Risk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met.
Dardiotis E, Koutsou P, Zamba-Papanicolaou E, Vonta I, Hadjivassiliou M, Hadjigeorgiou G, Cariolou M, Christodoulou K, Kyriakides T. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.
Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL. PCR-RFLP genotyping of C1q mutations and single nucleotide polymorphisms in Malaysian patients with systemic lupus erythematosus.
Chew CH, Chua KH, Lian LH, Puah SM, Tan SY. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T. | 03/13/2008 |
| The first analysis of C1q by mass spectrometry yields evidence that the B chain moiety of the globular head is involved in the interaction with fucoidan and underscores the particular role of arginine-109 in the charge pattern recognition property of C1q. | Mass spectrometry analysis of the oligomeric C1q protein reveals the B chain as the target of trypsin cleavage and interaction with fucoidan.
Tissot B, Gonnet F, Iborra A, Berthou C, Thielens N, Arlaud GJ, Daniel R. | 01/21/2010 |