| Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability. | Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.
Erdinc D, Rodríguez-Luis A, Fassad MR, Mackenzie S, Watson CM, Valenzuela S, Xie X, Menger KE, Sergeant K, Craig K, Hopton S, Falkous G, Genomics England Research Consortium, Poulton J, Garcia-Moreno H, Giunti P, de Moura Aschoff CA, Morales Saute JA, Kirby AJ, Toro C, Wolfe L, Novacic D, Greenbaum L, Eliyahu A, Barel O, Anikster Y, McFarland R, Gorman GS, Schaefer AM, Gustafsson CM, Taylor RW, Falkenberg M, Nicholls TJ., Free PMC Article | 05/11/2023 |
| Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy. | Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy.
Hansen AF, Høiem TS, Selnaes KM, Bofin AM, Størkersen Ø, Bertilsson H, Wright AJ, Giskeødegård GF, Bathen TF, Rye MB, Tessem MB. | 04/17/2023 |
| The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins. | The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins.
Soniat MM, Nguyen G, Kuo HC, Finkelstein IJ., Free PMC Article | 03/2/2023 |
| Two type I topoisomerases maintain DNA topology in human mitochondria. | Two type I topoisomerases maintain DNA topology in human mitochondria.
Menger KE, Chapman J, Díaz-Maldonado H, Khazeem MM, Deen D, Erdinc D, Casement JW, Di Leo V, Pyle A, Rodríguez-Luis A, Cowell IG, Falkenberg M, Austin CA, Nicholls TJ., Free PMC Article | 11/12/2022 |
| TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT. | TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.
de Nonneville A, Salas S, Bertucci F, Sobinoff AP, Adélaïde J, Guille A, Finetti P, Noble JR, Churikov D, Chaffanet M, Lavit E, Pickett HA, Bouvier C, Birnbaum D, Reddel RR, Géli V., Free PMC Article | 10/15/2022 |
| The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops. | The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops.
Harami GM, Pálinkás J, Seol Y, Kovács ZJ, Gyimesi M, Harami-Papp H, Neuman KC, Kovács M., Free PMC Article | 02/26/2022 |
| Duplex DNA and BLM regulate gate opening by the human TopoIIIalpha-RMI1-RMI2 complex. | Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.
Bakx JAM, Biebricher AS, King GA, Christodoulis P, Sarlós K, Bizard AH, Hickson ID, Wuite GJL, Peterman EJG., Free PMC Article | 02/19/2022 |
| Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder. | Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder.
Jiang W, Jia N, Guo C, Wen J, Wu L, Ogi T, Zhang H. | 09/11/2021 |
| Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells. | Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells.
Aschacher T, Wolf B, Aschacher O, Enzmann F, Laszlo V, Messner B, Türkcan A, Weis S, Spiegl-Kreinecker S, Holzmann K, Laufer G, Ehrlich M, Bergmann M., Free PMC Article | 05/29/2021 |
| Top3alpha is shown to be an essential component of the mitochondrial DNA replication machinery and as the first component of the mitochondrial DNA separation machinery. | Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.
Nicholls TJ, Nadalutti CA, Motori E, Sommerville EW, Gorman GS, Basu S, Hoberg E, Turnbull DM, Chinnery PF, Larsson NG, Larsson E, Falkenberg M, Taylor RW, Griffith JD, Gustafsson CM., Free PMC Article | 12/22/2018 |
| The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex. | Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
Daley JM, Chiba T, Xue X, Niu H, Sung P., Free PMC Article | 02/28/2015 |
| hTOP3alpha interacts with p53, regulates p53 and p21 expression, and contributes to the p53-mediated tumor suppression | DNA topoisomerase III alpha regulates p53-mediated tumor suppression.
Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK. | 12/20/2014 |
| MPS1 protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III alpha-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis | Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.
Pradhan A, Singh TR, Ali AM, Wahengbam K, Meetei AR., Free PMC Article | 02/8/2014 |
| Study found a correlation between topoisomerase IIIalpha immunoexpression and oral squamous cell carcinoma (OSCC) cancer stem cell immunophenotypes. However, results did not show a prognostic significance of topoisomerases in OSCC> | Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis.
Oliveira-Costa JP, Oliveira LR, da Silveira GG, Soave DF, Soares FA, Ribeiro-Silva A. | 06/1/2013 |
| TOP3A, a new partner gene fused to MLL in an adult patient with de novo acute myeloid leukaemia. | TOP3A, a new partner gene fused to MLL in an adult patient with de novo acute myeloid leukaemia.
Herbaux C, Poulain S, Meyer C, Marschalek R, Renneville A, Fernandes J, Theisen O, Tricot S, Simon M, Duthilleul P, Daudignon A. | 03/30/2013 |
| human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity | Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.
Yang J, Bachrati CZ, Ou J, Hickson ID, Brown GW., Free PMC Article | 08/16/2010 |
| G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells | The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.
Temime-Smaali N, Guittat L, Sidibe A, Shin-ya K, Trentesaux C, Riou JF., Free PMC Article | 02/8/2010 |
| Individuals carrying genetic variants of the BLM-TOP3A-RMI1 complex have an increased risk of acute myeloid leukemia/myelodysplatic syndromes, malignant melanoma, bladder and breast cancer. | Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M, Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M., Free PMC Articles: PMC2685436, PMC2685436 | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M, Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M., Free PMC Articles: PMC2685436, PMC2685436 | 05/17/2009 |
| evolutionarily conserved N-terminal third of BLAP75 mediates complex formation with BLM and Topo IIIalpha and that the DNA binding activity resides in the C-terminal third of this novel protein. | Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing.
Raynard S, Zhao W, Bussen W, Lu L, Ding YY, Busygina V, Meetei AR, Sung P., Free PMC Article | 01/21/2010 |
| Topo IIIalpha is an important telomere-associated factor, essential for telomere maintenance and chromosome stability in ALT cells, and speculate on its potential mechanistic function. | Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.
Temime-Smaali N, Guittat L, Wenner T, Bayart E, Douarre C, Gomez D, Giraud-Panis MJ, Londono-Vallejo A, Gilson E, Amor-Guéret M, Riou JF., Free PMC Article | 01/21/2010 |
| BLM is stably associated with TOP3A. | Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.
Bussen W, Raynard S, Busygina V, Singh AK, Sung P. | 01/21/2010 |
| The effects of TOP3 on telomere binding in human and S. cerevisiae cells are reported. | Involvement of topoisomerase III in telomere-telomere recombination.
Tsai HJ, Huang WH, Li TK, Tsai YL, Wu KJ, Tseng SF, Teng SC. | 01/21/2010 |
| The Bloom's syndrome helicase stimulates the activity of topoisomerase IIIalpha | The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.
Wu L, Hickson ID., Free PMC Article | 01/21/2010 |
| BLM, Topo IIIalpha, and BLAP75 constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation | A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.
Raynard S, Bussen W, Sung P. | 01/21/2010 |