| MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4. | MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4.
Yan J, Xie B, Tian Y, An W, Peng Z, Liu Z, Li J, Li L., Free PMC Article | 06/23/2023 |
| Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer. | Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer.
Guo Q, Zhao L, Yan N, Li Y, Guo C, Dang S, Shen X, Han J, Luo Y., Free PMC Article | 04/6/2023 |
| LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation. | LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation.
Luo A, Lan X, Qiu Q, Zhou Q, Li J, Wu M, Liu P, Zhang H, Lu B, Lu Y, Lu W., Free PMC Article | 11/19/2022 |
| Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding. | Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.
Stapley RJ, Poulter NS, Khan AO, Smith CW, Bignell P, Fratter C, Lester W, Lowe G, Morgan NV, UK GAPP Study Group. | 03/19/2022 |
| The miR-133a, TPM4 and TAp63gamma Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression. | The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression.
Caporali S, Calabrese C, Minieri M, Pieri M, Tarantino U, Marini M, D'Ottavio S, Angeletti S, Mauriello A, Cortese C, Bernardini S, Terrinoni A., Free PMC Article | 10/23/2021 |
| The expression and clinical significance of TPM4 in hepatocellular carcinoma. | The expression and clinical significance of TPM4 in hepatocellular carcinoma.
Li L, Ye T, Zhang Q, Li X, Ma L, Yan J., Free PMC Article | 09/11/2021 |
| Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin-4 in alpha-fetoprotein-negative hepatocellular carcinoma. | Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin-4 in alpha-fetoprotein-negative hepatocellular carcinoma.
Gong X, Huang A., Free PMC Article | 06/26/2021 |
| TPM4 aggravates the malignant progression of hepatocellular carcinoma through negatively regulating SUSD2. | TPM4 aggravates the malignant progression of hepatocellular carcinoma through negatively regulating SUSD2.
Sheng ZG, Chen MH. | 04/24/2021 |
| Upregulation of tropomyosin alpha-4 chain in patients' saliva with oral squamous cell carcinoma as demonstrated by Phage display. | Upregulation of tropomyosin alpha-4 chain in patients' saliva with oral squamous cell carcinoma as demonstrated by Phage display.
Faria PCB, Carneiro AP, Binato R, Nascimento R, Santos PS, Fagundes D, da Silva SJ, Loyola AM, Abdelhay E, Goulart LR., Free PMC Article | 11/21/2020 |
| TPM4 is associated with clinical progression in colon cancer patients and acts as a tumor suppressor in colon cancer cells. | The clinical significance and biological function of tropomyosin 4 in colon cancer.
Yang R, Zheng G, Ren D, Chen C, Zeng C, Lu W, Li H. | 09/29/2018 |
| Tpm4.1 is essential to maintain cell-cell adhesions and to inhibit abnormal increases in cell migration and invasion, which are important to prevent invasion and metastasis of breast cancer cells. | Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.
Jeong S, Lim S, Schevzov G, Gunning PW, Helfman DM., Free PMC Article | 03/10/2018 |
| findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder. | Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.
Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT., Free PMC Article | 09/9/2017 |
| In diabetes, expression of high molecular weight (HMW) isoforms from tropomyosin 1 (TPM1) were markedly decreased but HMW isoforms from tropomyosin 4 (TPM4) were not significantly different. | Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients.
Savill SA, Leitch HF, Harvey JN, Thomas TH., Free PMC Article | 08/19/2017 |
| Results show that Tpm4.2 facilitates the transition of NM-2A to the strongly actin-binding myosin-ADP state. | Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2.
Hundt N, Steffen W, Pathan-Chhatbar S, Taft MH, Manstein DJ., Free PMC Article | 01/14/2017 |
| In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls. | Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer.
Tang HY, Beer LA, Tanyi JL, Zhang R, Liu Q, Speicher DW., Free PMC Article | 03/22/2014 |
| Data indicate the upregulation of tropomyosin-4 in infiltrating ductal breast carcinomas (IDCAs) tissues, which may suggest its involvement in breast cancer development. | Tropomyosin-4 correlates with higher SBR grades and tubular differentiation in infiltrating ductal breast carcinomas: an immunohistochemical and proteomics-based study.
Kabbage M, Trimeche M, Ben Nasr H, Hammann P, Kuhn L, Hamrita B, Chahed K. | 02/22/2014 |
| Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 with lung cancer. | Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.
Rostila A, Puustinen A, Toljamo T, Vuopala K, Lindström I, Nyman TA, Oksa P, Vehmas T, Anttila SL. | 11/17/2012 |
| TPM4, PDIA and SRC8 were also localized to the trophoblast cells, further highlighting the importance of these cytoskeletal remodelling proteins in early pregnancy | Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys.
Paule S, Li Y, Nie G. | 11/5/2011 |
| Low TPM4 expression in the cytoplasm is associated with uterine cervix carcinogenesis. | Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value.
Lomnytska MI, Becker S, Bodin I, Olsson A, Hellman K, Hellström AC, Mints M, Hellman U, Auer G, Andersson S., Free PMC Article | 02/26/2011 |
| This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia | Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
Martins-de-Souza D, Schmitt A, Röder R, Lebar M, Schneider-Axmann T, Falkai P, Turck CW. | 04/22/2010 |
| Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle. | Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle.
Vlahovich N, Schevzov G, Nair-Shaliker V, Ilkovski B, Artap ST, Joya JE, Kee AJ, North KN, Gunning PW, Hardeman EC. | 01/21/2010 |