| Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals. | Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals.
González-de-Olano D, Navarro-Navarro P, Muñoz-González JI, Sánchez-Muñoz L, Henriques A, de-Andrés-Martín A, Peralta-Arjonilla D, Mayado A, Jara-Acevedo M, García-Montero AC, Orfao A, Álvarez-Twose I. | 03/4/2024 |
| Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1. | Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1.
Lyons JJ, Chovanec J, O'Connell MP, Liu Y, Šelb J, Zanotti R, Bai Y, Kim J, Le QT, DiMaggio T, Schwartz LB, Komarow HD, Rijavec M, Carter MC, Milner JD, Bonadonna P, Metcalfe DD, Korošec P. | 09/18/2021 |
| Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis. | Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis.
Greiner G, Sprinzl B, Górska A, Ratzinger F, Gurbisz M, Witzeneder N, Schmetterer KG, Gisslinger B, Uyanik G, Hadzijusufovic E, Esterbauer H, Gleixner KV, Krauth MT, Pfeilstöcker M, Keil F, Gisslinger H, Nedoszytko B, Niedoszytko M, Sperr WR, Valent P, Hoermann G., Free PMC Article | 04/24/2021 |
| Mast Cell beta-Tryptase Is Enzymatically Stabilized by DNA. | Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA.
Alanazi S, Grujic M, Lampinen M, Rollman O, Sommerhoff CP, Pejler G, Melo FR., Free PMC Article | 02/20/2021 |
| Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold. | Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold.
Finlin BS, Confides AL, Zhu B, Boulanger MC, Memetimin H, Taylor KW, Johnson ZR, Westgate PM, Dupont-Versteegden EE, Kern PA., Free PMC Article | 10/24/2020 |
| Allosteric effects of alpha-tryptase protomers on neighboring beta-tryptase protomers likely result in the novel substrate repertoire of alpha/beta-tryptase tetramers that in turn cause some of the clinical features of hereditary alpha-tryptasemia and of other disorders involving mast cells. | Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.
Le QT, Lyons JJ, Naranjo AN, Olivera A, Lazarus RA, Metcalfe DD, Milner JD, Schwartz LB., Free PMC Article | 06/13/2020 |
| The patient-specific 3D microtissues reveal a cascade of interactions between prostatic cancer-associated fibroblast, their native extensive extracellular matrix and mast cell-derived tryptase, rendering them important microenvironmental drivers of prostate cancer progression. | Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro.
Pereira BA, Lister NL, Hashimoto K, Teng L, Flandes-Iparraguirre M, Eder A, Sanchez-Herrero A, Niranjan B, Melbourne Urological Research Alliance (MURAL). | 05/23/2020 |
| Basal serum tryptase in children with actual drug hypersensitivity is not a risk factor for severe systemic reactions | Basal serum tryptase is not a risk factor for immediate-type drug hypersensitivity during childhood.
Cavkaytar O, Karaatmaca B, Arik Yilmaz E, Sahiner UM, Sackesen C, Sekerel BE, Soyer O. | 01/6/2018 |
| Increased TPSAB1 copy number is associated with multisystem disorder. | Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD., Free PMC Article | 09/9/2017 |
| this study shows that active cow's milk-induced enterocolitis syndrome children have higher serum tryptase levels compared to resolved disease | Humoral and cellular responses to casein in patients with food protein-induced enterocolitis to cow's milk.
Caubet JC, Bencharitiwong R, Ross A, Sampson HA, Berin MC, Nowak-Węgrzyn A. | 08/5/2017 |
| sBT levels may have a potential use in supporting a diagnosis of asthma in children and as a predictor of disease severity. | Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity.
Gao S, Fan J, Wang Z. | 02/25/2017 |
| CD3 showed a positive correlation with tryptase and microvascular density, while multiple regression analysis efficaciously predicted microvascular density depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in Diffuse large B cell lymphoma patients. | T cells, mast cells and microvascular density in diffuse large B cell lymphoma.
Marinaccio C, Ingravallo G, Gaudio F, Perrone T, Ruggieri S, Opinto G, Nico B, Maiorano E, Specchia G, Ribatti D. | 02/18/2017 |
| We found the determination of serum tryptase levels over time to be a reassuring correlate of clinical improvement in pediatric mastocytosis | Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis.
Carter MC, Clayton ST, Komarow HD, Brittain EH, Scott LM, Cantave D, Gaskins DM, Maric I, Metcalfe DD., Free PMC Article | 05/7/2016 |
| genetic polymorphism is associated with Dengue Hemorrhagic Fever and Dengue Shock Syndrome in Vietnam and Philippines | Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Velasquez CV, Roman AD, Lan NT, Huy NT, Mercado ES, Espino FE, Perez ML, Huong VT, Thuy TT, Tham VD, Nga CT, Ha TT, Bilar JM, Bajaro JD, Baello BQ, Kikuchi M, Yasunami M, Morita K, Watanabe N, Karbwang J, Hirayama K. | 02/27/2016 |
| Elevated serum tryptase and ET-1 may be markers of increased coronary instability; some cytokines may be related to the extension of CAD. | Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report.
Lewicki L, Siebert J, Marek-Trzonkowska N, Masiewicz E, Kolinski T, Reiwer-Gostomska M, Targonski R, Trzonkowski P., Free PMC Article | 02/13/2016 |
| these data suggest that the expression of tryptase is regulated by SCF/C-KIT signaling via the ERK1/2 and p38MAPK pathways. | SCF/C-KIT signaling modulates tryptase expression in acute myeloid leukemia cells.
Jin J, Li Y, Wang Y, Wang P, Wang Y. | 04/18/2015 |
| Urine tryptase beta was increased in patients with chronic prostatitis/chronic pelvic pain syndrome compared to controls. | Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.
Roman K, Done JD, Schaeffer AJ, Murphy SF, Thumbikat P., Free PMC Article | 02/14/2015 |
| Results demonstrated serum tryptase levels in colo-rectal cancer (CRC) patients before radical surgical resection. | Correlation between serum tryptase, mast cells positive to tryptase and microvascular density in colo-rectal cancer patients: possible biological-clinical significance.
Ammendola M, Sacco R, Sammarco G, Donato G, Montemurro S, Ruggieri E, Patruno R, Marech I, Cariello M, Vacca A, Gadaleta CD, Ranieri G., Free PMC Article | 01/31/2015 |
| Circulating tryptase level is associated to obesity related parameters and has a close relation with various metabolic risk factors for subclinical atherosclerosis | Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects.
Moreno M, Puig J, Serrano M, Moreno-Navarrete JM, Ortega F, Ricart W, Fernandez-Real JM., Free PMC Article | 01/24/2015 |
| Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma. | Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.
Abdelmotelb AM, Rose-Zerilli MJ, Barton SJ, Holgate ST, Walls AF, Holloway JW., Free PMC Article | 01/10/2015 |
| The best criterion for discriminating IgE- and non IgE-mediated hypersensitivity reactions in anaesthesia was a tryptase value exceeding twice the basal one. | The usefulness of plasma histamine and different tryptase cut-off points in the diagnosis of peranaesthetic hypersensitivity reactions.
Berroa F, Lafuente A, Javaloyes G, Ferrer M, Moncada R, Goikoetxea MJ, Urbain CM, Sanz ML, Gastaminza G. | 09/20/2014 |
| With elevated tryptase level, a history of hornet sting-triggered anaphylaxis, and venom-specific IgE, a patient is at increased risk of severe life-threatening anaphylactic response to a future sting, as well as for having underlying clonal mastocytosis. | Anaphylactic reaction to white-faced hornet sting and elevated baseline (asymptomatic) serum tryptase.
Lieberman P, Schwartz LB. | 09/6/2014 |
| Monitoring of serum baseline tryptase in indolent systemic mastocytosis patients is closely associated with poor prognosis disease features as well as with disease progression. | Serum tryptase monitoring in indolent systemic mastocytosis: association with disease features and patient outcome.
Matito A, Morgado JM, Álvarez-Twose I, Sánchez-Muñoz L, Pedreira CE, Jara-Acevedo M, Teodosio C, Sánchez-López P, Fernández-Núñez E, Moreno-Borque R, García-Montero A, Orfao A, Escribano L., Free PMC Article | 06/21/2014 |
| The accumulated data in this review suggest that mast cells and their tryptases and chymases play important roles in tissue repair. | Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
Douaiher J, Succar J, Lancerotto L, Gurish MF, Orgill DP, Hamilton MJ, Krilis SA, Stevens RL., Free PMC Article | 05/17/2014 |
| The high density of tryptase(+) Mmast cells at invasive margins of tumours was associated with advanced stages of colorectal cancer and was strongly correlated with PAR-2 expression. | High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression.
Malfettone A, Silvestris N, Saponaro C, Ranieri G, Russo A, Caruso S, Popescu O, Simone G, Paradiso A, Mangia A., Free PMC Article | 05/3/2014 |