| These results demonstrate for the first time that not only agonist binding but also abundance of some signaling proteins may strongly affect TRH receptor dynamics in the plasma membrane | TRH receptor mobility in the plasma membrane is strongly affected by agonist binding and by interaction with some cognate signaling proteins.
Moravcova R, Melkes B, Novotny J. | 08/18/2018 |
| a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH binding and TRHR-Gq coupling and signaling | Central Hypothyroidism Due to a TRHR Mutation Causing Impaired Ligand Affinity and Transactivation of Gq.
García M, González de Buitrago J, Jiménez-Rosés M, Pardo L, Hinkle PM, Moreno JC., Free PMC Article | 12/16/2017 |
| rs16892496 polymorphism in the TRHR gene may play a role in FFM variation. | Association between polymorphisms in the TRHR gene, fat-free mass, and muscle strength in older women.
Lunardi CC, Lima RM, Pereira RW, Leite TK, Siqueira AB, Oliveira RJ., Free PMC Article | 06/21/2014 |
| The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior. | Identification of a preassembled TRH receptor-G(q/11) protein complex in HEK293 cells.
Drastichova Z, Novotny J. | 04/28/2012 |
| Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails. | Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.
Gehret AU, Hinkle PM., Free PMC Article | 05/31/2010 |
| A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation. | Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.
Gehret AU, Jones BW, Tran PN, Cook LB, Greuber EK, Hinkle PM., Free PMC Article | 02/15/2010 |
| analysis of the effect of subcellular trafficking of the TRH receptor | Subcellular trafficking of the TRH receptor: effect of phosphorylation.
Jones BW, Hinkle PM., Free PMC Article | 01/21/2010 |
| TRHR gene is an important gene for LBM variation. | Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.
Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR, Papasian CJ, Deng HW, Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR, Papasian CJ, Deng HW., Free PMC Articles: PMC2668008, PMC2668008 | 01/21/2010 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.
Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR, Papasian CJ, Deng HW, Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR, Papasian CJ, Deng HW., Free PMC Articles: PMC2668008, PMC2668008 | 03/25/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesIdentification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Sex differences in environmental and genetic factors for hypertension.
Ruixing Y, Jinzhen W, Shangling P, Weixiong L, Dezhai Y, Yuming C. | 09/10/2008 |
| TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH administration in GH cell adenomas. | Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.
Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K. | 01/21/2010 |
| after agonist-driven receptor internalization, the plasma membrane is replenished with younger receptors, arising either from an intracellular pool or preferential recycling of younger receptors. | Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.
Cook LB, Hinkle PM. | 01/21/2010 |
| Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking. | Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.
Song GJ, Hinkle PM. | 01/21/2010 |