| In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection. | In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection.
Chen X, Yan Y, Liu Z, Yang S, Li W, Wang Z, Wang M, Guo J, Li Z, Zhu W, Yang J, Yin J, Dai Q, Li Y, Wang C, Zhao L, Yang X, Guo X, Leng L, Xu J, Obukhov AG, Cao R, Zhong W., Free PMC Article | 09/23/2024 |
| Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity. | Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity.
Chen Z, Zhao Y, Tian Y, Cao R, Shang D., Free PMC Article | 03/1/2023 |
| Expression of pH-Sensitive TRPC4 in Common Skin Tumors. | Expression of pH-Sensitive TRPC4 in Common Skin Tumors.
Kurz B, Michael HP, Förch A, Wallner S, Zeman F, Decking SM, Ugele I, Hintschich C, Haubner F, Ettl T, Renner K, Brochhausen C, Schreml S., Free PMC Article | 01/28/2023 |
| Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation. | Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
Zeng W, Ji Y, Zhang H, Chen L, Du L, Guo R., Free PMC Article | 01/22/2022 |
| Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma. | Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
Elzamzamy OM, Johnson BE, Chen WC, Hu G, Penner R, Hazlehurst LA., Free PMC Article | 10/30/2021 |
| Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels. | Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.
Ko J, Myeong J, Shin YC, So I., Free PMC Article | 09/26/2020 |
| Study reports a novel mechanism of self-limiting activation of TRPC1/4 and TRPC1/5 channels by G protein-coupled receptor stimulation. Galphaq protein directly interacts with either TRPC4 or TRPC5 of the heterotetrameric channels to permit activation. Simultaneously, Galphaq-coupled PLCbeta activation leads to the breakdown of PI(4,5)P2, which inhibits activity of TRPC1/4 and 1/5 channels. | Dual action of the Gα(q)-PLCβ-PI(4,5)P(2) pathway on TRPC1/4 and TRPC1/5 heterotetramers.
Myeong J, Ko J, Kwak M, Kim J, Woo J, Ha K, Hong C, Yang D, Kim HJ, Jeon JH, So I., Free PMC Article | 11/2/2019 |
| We found that the inhibitory Galphai3 protein selectively bound to the G-protein-binding domain on the C-terminus of PC1. The dissociation of Galphai3 upon cleavage of PC1 increased TRPC4 activity. | Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.
Kwak M, Hong C, Myeong J, Park EYJ, Jeon JH, So I., Free PMC Article | 09/14/2019 |
| Our results suggest that OGR1-dependent increases in TRPC4 expression may favor formation of highly Ca(2+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma. | Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.
Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, Glitsch MD., Free PMC Article | 05/12/2018 |
| Protein levels of TRPC4 were elevated in FCD II and tuberous sclerosis complex cortical samples compared to those of control samples. | Elevated Expression of TRPC4 in Cortical Lesions of Focal Cortical Dysplasia II and Tuberous Sclerosis Complex.
Wang LK, Chen X, Zhang CQ, Liang C, Wei YJ, Yue J, Liu SY, Yang H. | 03/31/2018 |
| STIM1L and TRPC1/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program. | TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca(2+) release in human myotubes.
Antigny F, Sabourin J, Saüc S, Bernheim L, Koenig S, Frieden M. | 07/15/2017 |
| These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family. | Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ., Free PMC Article | 06/10/2017 |
| silencing of TRPC4 alleviates angiogenesis induced by oxidized low-density lipoprotein in human coronary artery endothelial cells through inactivation of VEGF and NF-kappaB. | Silencing of Transient Receptor Potential Channel 4 Alleviates oxLDL-induced Angiogenesis in Human Coronary Artery Endothelial Cells by Inhibition of VEGF and NF-κB.
Qin W, Xie W, Xia N, He Q, Sun T., Free PMC Article | 12/17/2016 |
| slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA or enhancing PLCdelta function | Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
Thakur DP, Tian JB, Jeon J, Xiong J, Huang Y, Flockerzi V, Zhu MX., Free PMC Article | 06/28/2016 |
| Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation. | The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
Wie J, Kim BJ, Myeong J, Ha K, Jeong SJ, Yang D, Kim E, Jeon JH, So I., Free PMC Article | 05/7/2016 |
| Galpha(i2) activates the TRPC4 channel by direct binding. | Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process.
Myeong J, Kwak M, Jeon JP, Hong C, Jeon JH, So I. | 08/8/2015 |
| This study identifies a novel role for TRPC4 in the regulation of autophagy in vascular endothelial cells. | Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells.
Zhang L, Dai F, Cui L, Jing H, Fan P, Tan X, Guo Y, Zhou G. | 04/25/2015 |
| The higher amplitude of store-operated Ca2+ entry was associated to the over-expression for Stim2, Orai2-3, and TRPC1 while Stim2 levels remained constant and Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in primary myelofibrosis. | Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.
Dragoni S, Laforenza U, Bonetti E, Reforgiato M, Poletto V, Lodola F, Bottino C, Guido D, Rappa A, Pareek S, Tomasello M, Guarrera MR, Cinelli MP, Aronica A, Guerra G, Barosi G, Tanzi F, Rosti V, Moccia F., Free PMC Article | 02/28/2015 |
| a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure | Identification of a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure.
Myeong J, Kwak M, Hong C, Jeon JH, So I., Free PMC Article | 02/14/2015 |
| Tarbp2 binding to TRPC4 promotes changes of cytosolic Ca(2+) and, thereby, leads to a dynamic regulation of Dicer activity, essentially at low endogenous Dicer concentrations. | Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.
Zimmermann J, Latta L, Beck A, Leidinger P, Fecher-Trost C, Schlenstedt G, Meese E, Wissenbach U, Flockerzi V., Free PMC Article | 05/31/2014 |
| the enhanced apoptosis caused by the simultaneous depletion of Dp53 and Dmp52 is absolutely JNK-dependent. | During post-natal human myogenesis, normal myotube size requires TRPC1- and TRPC4-mediated Ca²⁺ entry.
Antigny F, Koenig S, Bernheim L, Frieden M. | 11/16/2013 |
| the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain. | Conserved gating elements in TRPC4 and TRPC5 channels.
Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh SA, Abdulmughni A, Cavalié A, Philipp SE, Zhu MX, Helms V, Wissenbach U, Flockerzi V., Free PMC Article | 09/14/2013 |
| an essential role of Galpha(i) proteins as novel activators for TRPC4/5 and reveal the molecular mechanism by which G-proteins activate the channels. | Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.
Jeon JP, Hong C, Park EJ, Jeon JH, Cho NH, Kim IG, Choe H, Muallem S, Kim HJ, So I., Free PMC Article | 07/28/2012 |
| Report association of a TRPC4 SNP with myocardial infarction in population-based genetic studies. Higher Ca(2+) signals generated by TRPC4-I957V may facilitate generation of endothelium/nitric oxide-dependent vasorelaxation. | A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction.
Jung C, Gené GG, Tomás M, Plata C, Selent J, Pastor M, Fandos C, Senti M, Lucas G, Elosua R, Valverde MA. | 11/26/2011 |
| Results showed a trend toward association of TRPC4 variants and photoparoxysmal response/idiopathic generalized epilepsies. | Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity.
von Spiczak S, Muhle H, Helbig I, de Kovel CG, Hampe J, Gaus V, Koeleman BP, Lindhout D, Schreiber S, Sander T, Stephani U. | 01/15/2011 |