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    TRPC6 transient receptor potential cation channel subfamily C member 6 [ Homo sapiens (human) ]

    Gene ID: 7225, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Immunohistochemical expression of the cation channel TRPC6 in the submandibular and lacrimal gland and in salivary gland tumors.

    Immunohistochemical expression of the cation channel TRPC6 in the submandibular and lacrimal gland and in salivary gland tumors.
    Carl C, Wagner M, Linxweiler M, Schick B, Tschernig T.

    09/25/2024
    Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.

    Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.
    Li S, Ma Q, Ma Z, Shi Y, Yu X, Gu B, Sun S, Yu C, Pang L., Free PMC Article

    04/22/2024
    [Expansion of the genotypic and phenotypic spectrum and treatment of four children with Steroid-resistant nephrotic syndrome due to variants of TRPC6 gene].

    [Expansion of the genotypic and phenotypic spectrum and treatment of four children with Steroid-resistant nephrotic syndrome due to variants of TRPC6 gene].
    Zhao G, Li J, Liu Y, Li G, Zhang Y, Zhang S, Liu C.

    04/5/2024
    The Multifunctional TRPC6 Protein: Significance in the Field of Cardiovascular Studies.

    The Multifunctional TRPC6 Protein: Significance in the Field of Cardiovascular Studies.
    Khan SU, Khan SU, Suleman M, Khan MU, Alsuhaibani AM, Refat MS, Hussain T, Ud Din MA, Saeed S.

    01/3/2024
    TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.

    TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.
    Wang M, Zhang X, Guo J, Yang S, Yang F, Chen X., Free PMC Article

    12/20/2023
    A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.

    A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.
    't Hart DC, van der Vlag J, Nijenhuis T., Free PMC Article

    12/4/2023
    An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis.

    An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis.
    Batool L, Hariharan K, Xu Y, Kaßmann M, Tsvetkov D, Gohlke BO, Kaden S, Gossen M, Nürnberg B, Kurtz A, Gollasch M., Free PMC Article

    08/25/2023
    Familial systemic lupus erythematosus associated with a loss-of-function mutation in TRPC6.

    Familial systemic lupus erythematosus associated with a loss-of-function mutation in TRPC6.
    Chen D, Yin H, Zhang L, Li F, Lu L.

    07/21/2023
    Improvement of platelet preservation by inhibition of TRPC6.

    Improvement of platelet preservation by inhibition of TRPC6.
    Tan Y, Lu W, Yi X, Cai H, Yuan Y, Zhang S.

    06/16/2023
    Is Zn[2+] the new Ca[2+] for TRPC6 channels in the myocardium?

    Is Zn(2+) the new Ca(2+) for TRPC6 channels in the myocardium?
    Dietrich A.

    02/4/2023
    TRPC6-protein expression in the elderly and in liver disease.

    TRPC6-protein expression in the elderly and in liver disease.
    Walz M, Tschernig T, Schmidt P, Federspiel JM.

    12/3/2022
    Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells.

    Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells.
    Zhao T, Parmisano S, Soroureddin Z, Zhao M, Yung L, Thistlethwaite PA, Makino A, Yuan JX., Free PMC Article

    10/8/2022
    TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity.

    TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity.
    Lu T, Sun X, Necela BM, Lee HC, Norton N., Free PMC Article

    10/1/2022
    Protein detection and localization of the non-selective cation channel TRPC6 in the human heart.

    Protein detection and localization of the non-selective cation channel TRPC6 in the human heart.
    Jacobs T, Abdinghoff J, Tschernig T.

    05/14/2022
    Klotho Ameliorates Podocyte Injury through Targeting TRPC6 Channel in Diabetic Nephropathy.

    Klotho Ameliorates Podocyte Injury through Targeting TRPC6 Channel in Diabetic Nephropathy.
    Yao X, Guo H, Sun M, Meng S, Zhu B, Fang J, Huang J, Wang H, Xing L., Free PMC Article

    05/7/2022
    Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.

    Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
    Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L.

    04/16/2022
    Novel gain-of-function mutation of TRPC6 Q134P contributes to late onset focal segmental glomerulosclerosis in a Chinese pedigree.

    Novel gain-of-function mutation of TRPC6 Q134P contributes to late onset focal segmental glomerulosclerosis in a Chinese pedigree.
    Liu Z, Zhang H, Zhao S, Zhang Q, Zhang R, Han Y, Shao L, Zhao X.

    03/19/2022
    OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma.

    OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma.
    Shao W, Hao ZY, Chen YF, Du J, He Q, Ren LL, Gao Y, Song N, Song Y, He H, Wang YZ., Free PMC Article

    02/19/2022
    Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.

    Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.
    Wang L, Mi J, Sun B, Yang G, Liu S, Chen M, Yu L, Pan J, Liu Y.

    02/12/2022
    Heterozygous missense variant in TRPC6 in a boy with rapidly progressive infantile nephrotic syndrome associated with diffuse mesangial sclerosis.

    Heterozygous missense variant in TRPC6 in a boy with rapidly progressive infantile nephrotic syndrome associated with diffuse mesangial sclerosis.
    Hanafusa H, Hidaka Y, Yamaguchi T, Shimojo H, Tsukahara T, Murase T, Matsuoka D, Chiba N, Shimada S, Morokawa H, Omori N, Minoura H, Nagano C, Takano K, Nakamura K, Wakui K, Fukushima Y, Uehara T, Nakazawa Y, Iijima K, Nozu K, Kosho T.

    01/1/2022
    The lncRNA TUG1 promotes cell growth and migration in colorectal cancer via the TUG1-miR-145-5p-TRPC6 pathway.

    The lncRNA TUG1 promotes cell growth and migration in colorectal cancer via the TUG1-miR-145-5p-TRPC6 pathway.
    Wang X, Bai X, Yan Z, Guo X, Zhang Y.

    08/28/2021
    Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple-negative breast cancer cells.

    Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple-negative breast cancer cells.
    Jardin I, Diez-Bello R, Falcon D, Alvarado S, Regodon S, Salido GM, Smani T, Rosado JA., Free PMC Article

    08/21/2021
    Effect of HIF1alpha on the TRPC6 channel of glomerular podocytes under chronic hypoxia.

    Effect of HIF1α on the TRPC6 channel of glomerular podocytes under chronic hypoxia.
    Hu G, He Y, Li Y, Hu X, Liu S, Liao C, Zhang R, Zhou X, Sun H.

    08/14/2021
    DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels.

    DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels.
    Saidi H, Murtaza B, Khan AS, Koceir EA, Hichami A, Khan NA.

    06/12/2021
    The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose.

    The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose.
    Lang HB, Xie RX, Huang ML, Fang LY, Tang YB, Zhang F.

    03/27/2021
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