| GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-beta accumulation and neuroinflammation in middle-aged Shugoshin 1 mice. | GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.
Rao CV, Farooqui M, Madhavaram A, Zhang Y, Asch AS, Yamada HY., Free PMC Article | 08/28/2021 |
| The results show that shugoshin protects the centromeric synaptonemal complex in meiotic prophase and, in anaphase, promotes the proper segregation of partner chromosomes that are not linked by a crossover. | Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis.
Previato de Almeida L, Evatt JM, Chuong HH, Kurdzo EL, Eyster CA, Gladstone MN, Gómez-H L, Llano E, Meyer R, Pendas AM, Pezza RJ, Dawson DS., Free PMC Article | 03/21/2020 |
| The Sgo1(-/+) mouse may serve as a novel tool for investigating mechanisms of spontaneous progression of Spontaneous late-onset Alzheimer's disease (LOAD) pathology, for early diagnosis markers, and for drug development. | Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model.
Rao CV, Farooqui M, Zhang Y, Asch AS, Yamada HY., Free PMC Article | 10/12/2019 |
| MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase. | SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.
Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K., Free PMC Article | 05/12/2018 |
| Study shows Sgo1 expression in heart, gut, eye and other central nervous system tissue during development and post-development. It demonstrates Sgo1 localization in cytoplasmic region in nucleated cells in select organs. | Characterization of Sgo1 expression in developing and adult mouse.
Song AT, Galli A, Leclerc S, Nattel S, Mandato C, Andelfinger G. | 02/3/2018 |
| Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression. | Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Krishnan S, Smits AH, Vermeulen M, Reinberg D., Free PMC Article | 09/30/2017 |
| Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages. | Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence.
Park SH, Xie S, Rao CV, Dai W., Free PMC Article | 10/29/2016 |
| Study established the Sgo1 haploinsufficient mouse as a colon cancer model and identified antagonizing oncogenic and tumor-suppressing pathways that are differentially expressed and may be responsible for the different dynamics in the tumor development. | Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model.
Rao CV, Sanghera S, Zhang Y, Biddick L, Reddy A, Lightfoot S, Dai W, Yamada HY., Free PMC Article | 09/10/2016 |
| Sgo1(-/+)-mediated ME-CIN strongly promoted/progressed development of hepatocellular carcinoma in the presence of an initiator carcinogen, and it had a mild initiator effect by itself. | Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.
Yamada HY, Zhang Y, Reddy A, Mohammed A, Lightfoot S, Dai W, Rao CV., Free PMC Article | 06/20/2015 |
| Haploinsufficiency of SGO1 results in genomic instability manifested as missegregation of chromosomes and formation of extra centrosomal foci in both murine embryonic fibroblasts and adult bone marrow cells. | Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.
Yamada HY, Yao Y, Wang X, Zhang Y, Huang Y, Dai W, Rao CV., Free PMC Article | 09/15/2012 |
| It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion. | Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis.
Perera D, Taylor SS. | 05/31/2010 |
| report structure and function of the PP2A-shugoshin interaction. | Structure and function of the PP2A-shugoshin interaction.
Xu Z, Cetin B, Anger M, Cho US, Helmhart W, Nasmyth K, Xu W., Free PMC Article | 01/21/2010 |
| Prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1. | Shugoshin1 may play important roles in separation of homologous chromosomes and sister chromatids during mouse oocyte meiosis.
Yin S, Ai JS, Shi LH, Wei L, Yuan J, Ouyang YC, Hou Y, Chen DY, Schatten H, Sun QY., Free PMC Article | 01/21/2010 |