| The Human TSHbeta Subunit Proteins and Their Binding Sites on the TSH Receptor Using Molecular Dynamics Simulation. | The Human TSHβ Subunit Proteins and Their Binding Sites on the TSH Receptor Using Molecular Dynamics Simulation.
Mezei M, Baliram R, Ali MR, Zaidi M, Davies TF, Latif R., Free PMC Article | 01/9/2021 |
| Cold Exposure Distinctively Modulates Parathyroid and Thyroid Hormones in Cold-Acclimatized and Non-Acclimatized Humans. | Cold Exposure Distinctively Modulates Parathyroid and Thyroid Hormones in Cold-Acclimatized and Non-Acclimatized Humans.
Kovaničová Z, Kurdiová T, Baláž M, Štefanička P, Varga L, Kulterer OC, Betz MJ, Haug AR, Burger IA, Kiefer FW, Wolfrum C, Ukropcová B, Ukropec J. | 12/19/2020 |
| GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. | GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.
Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S, Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB, Gabrielsen ME, Skogholt AH, Surakka I, Davey Smith G, Pandit A, Roychowdhury T, Hornsby WE, Jonasson JG, Senter L, Liyanarachchi S, Ringel MD, Xu L, Kiemeney LA, He H, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hrafnkelsson J, Hjartarson H, Sturgis EM, Palotie A, Daly M, Citterio CE, Arvan P, Brummett CM, Boehnke M, de la Chapelle A, Stefansson K, Hveem K, Willer CJ, Åsvold BO., Free PMC Article | 09/12/2020 |
| dentification of a mutation in the TSHbeta gene reinforces the importance of identifying ICCH that can occur in the absence of elevated serum TSH and demonstrates the functional significance of the TSHbeta cysteine knot. | Central Congenital Hypothyroidism Caused by a Novel Mutation, C47W, in the Cysteine Knot Region of TSHβ.
Ebrhim RS, Bruellman RJ, Watanabe Y, Creech MK, Abdullah MA, Dumitrescu AM, Refetoff S, Weiss RE., Free PMC Article | 07/11/2020 |
| TSH level was found to be independently correlated with both carotid plaque prevalence and intima-media thickness. | Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Yang C, Lu M, Chen W, He Z, Hou X, Feng M, Zhang H, Bo T, Zhou X, Yu Y, Zhang H, Zhao M, Wang L, Yu C, Gao L, Jiang W, Zhang Q, Zhao J., Free PMC Article | 05/9/2020 |
| The Pathogenic TSH beta-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR. | The Pathogenic TSH β-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR.
Kalveram L, Kleinau G, Szymańska K, Scheerer P, Rivero-Müller A, Grüters-Kieslich A, Biebermann H., Free PMC Article | 03/28/2020 |
| Report of TSHB mutation causing central congenital hypothyroidism in a Brazilian family. | A RECURRENT MUTATION IN TSHB GENE UNDERLYING CENTRAL CONGENITAL HYPOTHYROIDISM UNDETECTABLE IN NEONATAL SCREENING.
Borges MF, Domené HM, Scaglia PA, Lara BHJ, Palhares HMDC, Santos AVA, Gonçalves ALF, Oliveira MM, Marqui ABT., Free PMC Article | 03/14/2020 |
| Serum macro TSH level is associated with sleep quality in patients with cardiovascular risks. | Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks - HSCAA Study.
Kadoya M, Koyama S, Morimoto A, Miyoshi A, Kakutani M, Hamamoto K, Kurajoh M, Shoji T, Moriwaki Y, Koshiba M, Yamamoto T, Inaba M, Namba M, Koyama H., Free PMC Article | 11/10/2018 |
| present the cases of two siblings with a novel mutation of TSHB. One of them was c.40A>G (rs10776792) which is a very common variation that is also seen in healthy individuals, the other was c.94G>A at codon 32 of exon 2 which resulted in a change from glutamic acid to lysine (p.E32K | Congenital Central Hypothyroidism Caused by a Novel Thyroid-Stimulating Hormone-Beta Subunit Gene Mutation in Two Siblings.
Özhan B, Boz Anlaş Ö, Sarıkepe B, Albuz B, Semerci Gündüz N., Free PMC Article | 05/26/2018 |
| The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. | Serum cytokine profile in patients with breast cancer.
Li L, Chen L, Zhang W, Liao Y, Chen J, Shi Y, Luo S. | 01/6/2018 |
| results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue | TSHB mRNA is linked to cholesterol metabolism in adipose tissue.
Moreno-Navarrete JM, Moreno M, Ortega F, Xifra G, Hong S, Asara JM, Serrano JCE, Jové M, Pissios P, Blüher M, Ricart W, Portero-Otin M, Fernández-Real JM., Free PMC Article | 10/21/2017 |
| In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant. | T3 Regulates a Human Macrophage-Derived TSH-β Splice Variant: Implications for Human Bone Biology.
Baliram R, Latif R, Morshed SA, Zaidi M, Davies TF., Free PMC Article | 07/1/2017 |
| In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction. | Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome.
van Tienhoven-Wind LJ, Dullaart RP., Free PMC Article | 05/20/2017 |
| the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported. | Maternal First Trimester TSH Concentrations: Do They Affect Perinatal and Endocrine Outcomes?
Fraenkel M, Shafat T, Erez O, Lichtenstein Y, Awesat J, Novack V, Tsur A. | 03/11/2017 |
| Data suggest that the subtle thyroid-stimulating hormone (TSH) reduction could possibly reflect minor hypothalamic-pituitary damage. | Increasing severity of traumatic brain injury in early childhood is associated with a progressive reduction in long-term serum thyroid-stimulating hormone concentrations.
Heather NL, Derraik JG, Chiavaroli V, Hofman PL, Cutfield WS. | 12/17/2016 |
| analysis of a single nucleotide substitution in TSHbeta related to clinical euthyroidism [family case report] | A TSHβ Variant with Impaired Immunoreactivity but Intact Biological Activity and Its Clinical Implications.
Pappa T, Johannesen J, Scherberg N, Torrent M, Dumitrescu A, Refetoff S., Free PMC Article | 06/4/2016 |
| Findings defined the immune-derived functional TSHb splice variant that resided in the thyroid of patients with Hashimoto's thyroiditis (HT), which exerted the unique effects on the pathogenesis of the disease. | Functional human TSHβ splice variant produced by plasma cell may be involved in the immunologic injury of thyroid in the patient with Hashimoto's thyroiditis.
Liu CR, Miao J, Zhao ZK, Li LY, Liu YM, Zhang YL, Li XH, Liu YQ, Gu YJ, Zhao Y, Luo JW. | 06/4/2016 |
| Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex. | Association of thyrotropin with arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study.
Hjelt S, Aatola H, Kähönen M, Juonala M, Koivistoinen T, Lehtimäki T, Viikari JS, Raitakari OT, Laitinen T, Hutri-Kähönen N. | 10/31/2015 |
| Higher TSH levels are associated with less favorable lipid levels in children | Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth.
Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H. | 10/3/2015 |
| In cases with isolated central congenital hypothyroidism and undetectably low TSH serum concentrations, a TSHbeta gene deletion should be considered | A novel deletion in the thyrotropin Beta-subunit gene identified by array comparative genomic hybridization analysis causes central congenital hypothyroidism in a boy originating from Turkey.
Hermanns P, Couch R, Leonard N, Klotz C, Pohlenz J. | 05/30/2015 |
| Epistasis between single nucleotide polymorphisms within the TSHB and ADAMTS16 genes may increase the risk of premature ovarian failure in Korean women. | Epistasis between polymorphisms in TSHB and ADAMTS16 is associated with premature ovarian failure.
Pyun JA, Kim S, Cha DH, Kwack K. | 04/18/2015 |
| High Thyroid Stimulating Hormone levels are associated with papillary thyroid carcinoma. | Thyroglobulin antibodies could be a potential predictive marker for papillary thyroid carcinoma.
Vasileiadis I, Boutzios G, Charitoudis G, Koukoulioti E, Karatzas T. | 04/4/2015 |
| bTSH Induces IL-6 Protein and mRNA in Orbital Fibroblasts and Fibrocytes | Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions.
Raychaudhuri N, Fernando R, Smith TJ., Free PMC Article | 07/12/2014 |
| The use of these age-specific reference intervals for TSH, especially in those over 70 years old, would result in the reclassification of many TSH results from "abnormal" to "normal" and avoid unnecessary treatment. | Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the Thyroid Epidemiology, Audit, and Research Study (TEARS).
Vadiveloo T, Donnan PT, Murphy MJ, Leese GP. | 05/4/2013 |
| In Hashimoto's thyroiditis the hTSHbeta splice variant exists in human serum and dimerises with TSHalpha. | A newly identified TSHβ splice variant is involved in the pathology of Hashimoto's thyroiditis.
Liu C, Li L, Ying F, Xu C, Zang X, Gao Z. | 04/6/2013 |