| Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110). | Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).
Chen Y, Su L, Huang C, Wu S, Qiu X, Zhao X, Meng Q, Meng YM, Kong X, Wang M, Liu C, Wong PP. | 06/26/2021 |
| These results provided evidence that CDK11(p110) play a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells, which suggests that CDK11(p110) may be a promising therapeutic target in esophageal squamous cell carcinoma. | CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.
Du Y, Yan D, Yuan Y, Xu J, Wang S, Yang Z, Cheng W, Tian X, Kan Q., Free PMC Article | 05/9/2020 |
| CDK11 has a role in human cancers [review] | The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.
Zhou Y, Shen JK, Hornicek FJ, Kan Q, Duan Z., Free PMC Article | 01/13/2018 |
| study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression | CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.
Kong X, Gan H, Hao Y, Cheng C, Jiang J, Hong Y, Yang J, Zhu H, Chi Y, Yun X, Gu J. | 01/21/2010 |
| These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells. | Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.
Wang Y, Zong H, Chi Y, Hong Y, Yang Y, Zou W, Yun X, Gu J. | 01/21/2010 |
| Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. | Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
Shi J, Hershey JW, Nelson MA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCentrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ. Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort.
Li Y, Wu G, Zuo J, Gao J, Chang Y, Fang FD, Li Y, Wu G, Zuo J, Gao J, Chang Y, Fang FD. | 03/13/2008 |
| CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population. | Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort.
Li Y, Wu G, Zuo J, Gao J, Chang Y, Fang FD, Li Y, Wu G, Zuo J, Gao J, Chang Y, Fang FD. | 01/21/2010 |
| findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis | CDK11(p58) is required for the maintenance of sister chromatid cohesion.
Hu D, Valentine M, Kidd VJ, Lahti JM. | 01/21/2010 |
| mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes | The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R., Free PMC Article | 01/21/2010 |
| the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle | Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S., Free PMC Article | 01/21/2010 |
| CDK11(p58) is a new interacting protein and a novel regulator of histone acetyltransferase (HAT) HBO1. | Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity.
Zong H, Li Z, Liu L, Hong Y, Yun X, Jiang J, Chi Y, Wang H, Shen X, Hu Y, Niu Z, Gu J. | 01/21/2010 |
| These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. | The cyclin-dependent kinase 11 interacts with NOT2.
Shi J, Nelson MA. | 01/21/2010 |
| CDK11p60 can contribute to apoptosis by direct signalling at the mitochondria, thereby amplifying Fas-induced apoptosis in melanoma cells. | Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria.
Feng Y, Ariza ME, Goulet AC, Shi J, Nelson MA., Free PMC Article | 01/21/2010 |
| CDK11 kinases could be regulated by interaction with 14-3-3 proteins during cell cycle and apoptosis | The cyclin-dependent kinase 11 interacts with 14-3-3 proteins.
Feng Y, Qi W, Martinez J, Nelson MA. | 01/21/2010 |
| demonstrates that CDK11(p46) directly interacts with RanBPM in vitro and in human cells | The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.
Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M. | 01/21/2010 |