| PLIN4-related myopathy: clinical, histological and imaging data in a large cohort of patients. | PLIN4-related myopathy: clinical, histological and imaging data in a large cohort of patients.
Maggi L, Gibertini S, Iannibelli E, Gallone A, Bonanno S, Cazzato D, Gerevini S, Moscatelli M, Blasevich F, Riolo G, Mantegazza R, Ruggieri A., Free PMC Article | 08/14/2023 |
| Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly. | Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly.
Giménez-Andrés M, Emeršič T, Antoine-Bally S, D'Ambrosio JM, Antonny B, Derganc J, Čopič A., Free PMC Article | 09/18/2021 |
| Multiomic elucidation of a coding 99-mer repeat-expansion skeletal muscle disease. | Multiomic elucidation of a coding 99-mer repeat-expansion skeletal muscle disease.
Ruggieri A, Naumenko S, Smith MA, Iannibelli E, Blasevich F, Bragato C, Gibertini S, Barton K, Vorgerd M, Marcus K, Wang P, Maggi L, Mantegazza R, Dowling JJ, Kley RA, Mora M, Minassian BA., Free PMC Article | 08/7/2021 |
| These findings underlie the importance of a novel morphologic-metabolic phenotype associated with chemotherapy resistance in triple-negative breast cancer , and bring to light novel therapeutic targets resulting from vulnerabilities in this phenotype, including the expression of PLIN4 essential for stabilizing lipid droplets in resistant cells. | A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.
Sirois I, Aguilar-Mahecha A, Lafleur J, Fowler E, Vu V, Scriver M, Buchanan M, Chabot C, Ramanathan A, Balachandran B, Légaré S, Przybytkowski E, Lan C, Krzemien U, Cavallone L, Aleynikova O, Ferrario C, Guilbert MC, Benlimame N, Saad A, Alaoui-Jamali M, Saragovi HU, Josephy S, O'Flanagan C, Hursting SD, Richard VR, Zahedi RP, Borchers CH, Bareke E, Nabavi S, Tonellato P, Roy JA, Robidoux A, Marcus EA, Mihalcioiu C, Majewski J, Basik M. | 06/27/2020 |
| We investigated whether the presence of the A allele of rs8887 SNP (PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control. There was a significant interaction between birth weight and the presence of the A allele on SSRT performance,in which lower birth weight associated with poorer inhibitory control only in non-carrier | Moderating effect of PLIN4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age.
Rodrigues DM, Manfro GG, Levitan RD, Steiner M, Meaney MJ, Silveira PP. | 08/17/2019 |
| Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. | A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets.
Čopič A, Antoine-Bally S, Giménez-Andrés M, La Torre Garay C, Antonny B, Manni MM, Pagnotta S, Guihot J, Jackson CL., Free PMC Article | 12/22/2018 |
| Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. | Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms.
Maia-Landim A, Ramírez JM, Lancho C, Poblador MS, Lancho JL., Free PMC Article | 03/10/2018 |
| PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. | Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training.
Peters SJ, Samjoo IA, Devries MC, Stevic I, Robertshaw HA, Tarnopolsky MA. | 09/29/2012 |
| we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits | A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study.
Cusano NE, Kiel DP, Demissie S, Karasik D, Adrienne Cupples L, Corella D, Gao Q, Richardson K, Yiannakouris N, Ordovas JM., Free PMC Article | 05/19/2012 |
| These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site | The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.
Richardson K, Louie-Gao Q, Arnett DK, Parnell LD, Lai CQ, Davalos A, Fox CS, Demissie S, Cupples LA, Fernandez-Hernando C, Ordovas JM., Free PMC Article | 03/16/2012 |
| Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. | Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.
Sone Y, Yamaguchi K, Fujiwara A, Kido T, Kawahara K, Ishiwaki A, Kondo K, Morita Y, Tominaga N, Otsuka Y, Sone Y, Yamaguchi K, Fujiwara A, Kido T, Kawahara K, Ishiwaki A, Kondo K, Morita Y, Tominaga N, Otsuka Y. | 09/6/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males.
Sone Y, Yamaguchi K, Fujiwara A, Kido T, Kawahara K, Ishiwaki A, Kondo K, Morita Y, Tominaga N, Otsuka Y, Sone Y, Yamaguchi K, Fujiwara A, Kido T, Kawahara K, Ishiwaki A, Kondo K, Morita Y, Tominaga N, Otsuka Y. | 06/30/2010 |
| Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12. | Adipocyte protein S3-12 coats nascent lipid droplets.
Wolins NE, Skinner JR, Schoenfish MJ, Tzekov A, Bensch KG, Bickel PE. | 12/11/2006 |