| Functional genetic variants in complement component 7 confer susceptibility to gastric cancer. | Functional genetic variants in complement component 7 confer susceptibility to gastric cancer.
Wang S, Hu W, Xie Y, Wu H, Jia Z, Zhang Z, Zhang X., Free PMC Article | 02/9/2023 |
| Similarities and differences in the structures and proteoform profiles of the complement proteins C6 and C7. | Similarities and differences in the structures and proteoform profiles of the complement proteins C6 and C7.
Lukassen MV, Franc V, Hevler JF, Heck AJR. | 01/29/2022 |
| Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome. | Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome.
Aarsetøy R, Ueland T, Aukrust P, Michelsen AE, Leon de la Fuente R, Grundt H, Staines H, Nygaard O, Nilsen DWT., Free PMC Article | 01/22/2022 |
| Recipient C7 rs9292795 genotype and the risk of hepatocellular carcinoma recurrence after orthotopic liver transplantation in a Han Chinese population. | Recipient C7 rs9292795 genotype and the risk of hepatocellular carcinoma recurrence after orthotopic liver transplantation in a Han Chinese population.
Jiang Z, Jiang Q, Fang X, Wang P, Que W, Li H, Yu Y, Liu X, Wang C, Zhong L., Free PMC Article | 12/25/2021 |
| The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population. | The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population.
He J, Fu J, Fan D. | 11/22/2021 |
| Evaluation of Serum and Gene Expression of Galectin-4, Interleukin-27, and Complement-7 in Hepatitis C Virus-Infected Egyptian Patients. | Evaluation of Serum and Gene Expression of Galectin-4, Interleukin-27, and Complement-7 in Hepatitis C Virus-Infected Egyptian Patients.
Abdel-Tawab MS, Fouad HH, Omran DA, Abdou AE, Zaied SM, Mohamed AA., Free PMC Article | 06/19/2021 |
| this study shows that GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C | Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C.
de Lima RE, de Holanda Martins CM, do Carmo RF, Aroucha DCBL, Pereira LMMB, Vasconcelos LRS, Moura P. | 12/22/2018 |
| Two case reports of C7 deficiency leading to recurrent meningitis and other bacterial infections are described. | [Recurrent meningitis and inherited complement deficiency].
Šrotová A, Litzman J, Rumlarová Š, Drahošová M, Bartoňková D, Krčmová I, Roberts A, Jolles S, Králíčková P. | 09/30/2017 |
| The complement C7 rs6876739 CC genotypes and mannan-binding lectin (MBL2) gene polymorphisms of liver donors were significantly associated with bacterial infection in recipients. | C7 genotype of the donor may predict early bacterial infection after liver transplantation.
Zhong L, Li H, Li Z, Shi B, Wang P, Wang C, Fan J, Sun H, Wang P, Qin X, Peng Z., Free PMC Article | 03/4/2017 |
| Complement proteins C7 and CFH control the stemness of liver cancer cells via LSF-1 pathway. | Complement proteins C7 and CFH control the stemness of liver cancer cells via LSF-1.
Seol HS, Lee SE, Song JS, Rhee JK, Singh SR, Chang S, Jang SJ., Free PMC Article | 07/16/2016 |
| Complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. | Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.
Shi H, Williams JA, Guo L, Stampoulis D, Francesca Cordeiro M, Moss SE., Free PMC Article | 01/16/2016 |
| Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC). | CspA from Borrelia burgdorferi inhibits the terminal complement pathway.
Hallström T, Siegel C, Mörgelin M, Kraiczy P, Skerka C, Zipfel PF., Free PMC Article | 01/25/2014 |
| These overall results suggest a lack of strong association with the C2 and C7 gene polymorphisms to the susceptibility of systemic lupus erythematosus in the Malaysian population. | Complement components 2 and 7 (C2 and C7) gene polymorphisms are not major risk factors for SLE susceptibility in the Malaysian population.
Lian LH, Ching AS, Chong ZY, Chua KH. | 05/18/2013 |
| Studies indicate that the deletion defect may be a more commonly distributed cause of C7 deficiency in Ireland. | Characterization of a large genomic deletion in four Irish families with C7 deficiency.
Thomas AD, Orren A, Connaughton J, Feighery C, Morgan BP, Roberts AG. | 05/12/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| Complement C5b-9 induce a JNK/Bid-dependent and JNK-independent necrotic cell death. | Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.
Gancz D, Donin N, Fishelson Z. | 06/8/2010 |
| C7 isoelectric focusing variants can determine meningococcal killing in the early stage of infection when antibody-independent killing prevails. | Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease.
Kuijpers TW, Nguyen M, Hopman CT, Nieuwenhuys E, Dewald G, Lankester AC, Roos A, van der Ende A, Fijen C, de Boer M. | 02/22/2010 |
| Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 dependent and this is in part through regulation of Akt and growth factor release. | Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.
Fosbrink M, Cudrici C, Tegla CA, Soloviova K, Ito T, Vlaicu S, Rus V, Niculescu F, Rus H., Free PMC Article | 01/21/2010 |
| Data show that the two C7-FIMs pack closely together with an approximate 2-fold rotational symmetry that is rarely seen in module pairs and has not been observed in FD-containing proteins. | Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.
Phelan MM, Thai CT, Soares DC, Ogata RT, Barlow PN, Bramham J., Free PMC Article | 01/21/2010 |
| C7 is associated with multiple sclerosis pathogenesis. | Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J, Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J., Free PMC Articles: PMC2667286, PMC2667286 | 01/21/2010 |
| membrane associated C7 acts as a trap for the late complement components to control excessive inflammation induced by SC5b-9 | C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function.
Bossi F, Rizzi L, Bulla R, Debeus A, Tripodo C, Picotti P, Betto E, Macor P, Pucillo C, Würzner R, Tedesco F. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (8) articlesRisk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.
Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J, Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.
Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, Jones S, Collins A, Stone E, Lotery A. | 11/2/2008 |
| Observational study and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Evidence for association between multiple complement pathway genes and AMD.
Dinu V, Miller PL, Zhao H. | 03/13/2008 |
| The interaction between the factor I domain of C7 and the C345C domain at the C terminus of the C5 alpha-chain plays an essential role in complement membrane attack complex formation and complement lytic activity. | Recombinant C345C and factor I modules of complement components C5 and C7 inhibit C7 incorporation into the complement membrane attack complex.
Thai CT, Ogata RT. | 01/21/2010 |