| UBB(+1) reduces amyloid-beta cytotoxicity by activation of autophagy in yeast. | UBB(+1) reduces amyloid-β cytotoxicity by activation of autophagy in yeast.
Chen X, Muñoz-Arellano AJ, Petranovic D., Free PMC Article | 02/5/2022 |
| Bioinformatics analysis of mRNA and miRNA microarray to identify the key miRNA-mRNA pairs in cisplatin-resistant ovarian cancer. | Bioinformatics analysis of mRNA and miRNA microarray to identify the key miRNA-mRNA pairs in cisplatin-resistant ovarian cancer.
Xue B, Li S, Jin X, Liu L., Free PMC Article | 08/7/2021 |
| High Expression of UBB, RAC1, and ITGB1 Predicts Worse Prognosis among Nonsmoking Patients with Lung Adenocarcinoma through Bioinformatics Analysis. | High Expression of UBB, RAC1, and ITGB1 Predicts Worse Prognosis among Nonsmoking Patients with Lung Adenocarcinoma through Bioinformatics Analysis.
Deng H, Huang Y, Wang L, Chen M., Free PMC Article | 05/8/2021 |
| The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells. | The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells.
Scarpa ES, Tasini F, Crinelli R, Ceccarini C, Magnani M, Bianchi M., Free PMC Article | 02/20/2021 |
| Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation. | Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation.
Park CW, Bae JS, Ryu KY. | 02/20/2021 |
| The Molecular Misreading of APP and UBB Induces a Humoral Immune Response in Alzheimer's Disease Patients with Diagnostic Ability. | The Molecular Misreading of APP and UBB Induces a Humoral Immune Response in Alzheimer's Disease Patients with Diagnostic Ability.
Montero-Calle A, San Segundo-Acosta P, Garranzo-Asensio M, Rábano A, Barderas R. | 11/28/2020 |
| this study shows that molecular mimicry of human ubiquitin by Bacteroides fragilis ubiquitin could be a trigger for autoimmune disease. | Antigenic mimicry of ubiquitin by the gut bacterium Bacteroides fragilis: a potential link with autoimmune disease.
Stewart L, D M Edgar J, Blakely G, Patrick S., Free PMC Article | 08/31/2019 |
| Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C. | Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.
Kedves AT, Gleim S, Liang X, Bonal DM, Sigoillot F, Harbinski F, Sanghavi S, Benander C, George E, Gokhale PC, Nguyen QD, Kirschmeier PT, Distel RJ, Jenkins J, Goldberg MS, Forrester WC., Free PMC Article | 03/2/2019 |
| This study demonstrated that the Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam. | Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.
Verheijen BM, Hashimoto T, Oyanagi K, van Leeuwen FW., Free PMC Article | 08/18/2018 |
| The polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB have been characterized. | Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB(+1).
Chojnacki M, Zhang D, Talarowska M, Gałecki P, Szemraj J, Fushman D, Nakasone MA., Free PMC Article | 05/20/2017 |
| The C-terminal five residues of Ub, RLRGG, are responsible for the interaction with the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease. | Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Lei J, Hilgenfeld R., Free PMC Article | 04/1/2017 |
| A new crystallographic structure of human ubiquitin solved from crystals grown in the presence of magnesium. | New crystal form of human ubiquitin in the presence of magnesium.
Camara-Artigas A, Plaza-Garrido M, Martinez-Rodriguez S, Bacarizo J., Free PMC Article | 12/17/2016 |
| Data suggest that both human ubiquitin and HFBII (hydrophobin-II from Trichoderma reesei) exhibit a critical surface hydration level (or effective hydrophobic interface at the surface) at which percolation transition of water network occurs. | Protein-spanning water networks and implications for prediction of protein-protein interactions mediated through hydrophobic effects.
Cui D, Ou S, Patel S. | 07/25/2015 |
| UbB was significantly increased in prolonged Trichostatin A-selected HeLa cells and it played a key role in the maintenance of cervical cancer stem-like cells | Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters.
Tian Y, Ding W, Wang Y, Ji T, Sun S, Mo Q, Chen P, Fang Y, Liu J, Wang B, Zhou J, Ma D, Wu P., Free PMC Article | 10/18/2014 |
| downregulation of ubiquitin through Ubb-KD is a potential anti-cancer treatment by inhibiting ubiquitination at multiple sites related to oncogenic pathways and by weakening the ability of cancer cells to overcome increased stress. | Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention.
Oh C, Park S, Lee EK, Yoo YJ., Free PMC Article | 06/28/2014 |
| A significant decrease in amyloid beta deposition and plaque formation suggests a role for the ubiquitin-proteasome system in the amyloid pathology of Alzheimer's disease. | Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.
van Tijn P, Dennissen FJ, Gentier RJ, Hobo B, Hermes D, Steinbusch HW, Van Leeuwen FW, Fischer DF. | 08/3/2013 |
| age-dependent accumulation of Ubb(+1) , and how Ubb(+1) -mediated proteasome inhibition may contribute to Alzheimer's disease. [review] | Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.
Chadwick L, Gentle L, Strachan J, Layfield R. | 06/30/2012 |
| Studies indicate that biomedical research on ubiquitin moves into translational research and drug discovery. | A baker's dozen of ubiquitin.
Haas AL, Leach CA. | 10/22/2011 |
| Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation. | PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.
Kessler BM, Edelmann MJ., Free PMC Article | 10/22/2011 |
| analysis of orexin receptor 1 and 2 -arrestin-ubiquitin complexes | Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.
Dalrymple MB, Jaeger WC, Eidne KA, Pfleger KD., Free PMC Article | 07/16/2011 |
| The results of this study demonstrated that the UBB mutation caused the subtle defect in spatial reference memory formation, caused by a decrease in forebrain proteasome activity. | Alzheimer-associated mutant ubiquitin impairs spatial reference memory.
van Tijn P, Hobo B, Verhage MC, Oitzl MS, van Leeuwen FW, Fischer DF. | 04/30/2011 |
| Studies indicate that indicating that the inhibition of the ubiquitin-proteasome system could be used as a novel approach for cancer therapy. | The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.
Chen D, Dou QP., Free PMC Article | 03/5/2011 |
| Results suggest that the interaction between E2-25K and UBB(+1) is critical for the synthesis and accumulation of UBB(+1)-anchored polyubiquitin, which results in proteasomal inhibition and neuronal cell death. | Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.
Ko S, Kang GB, Song SM, Lee JG, Shin DY, Yun JH, Sheng Y, Cheong C, Jeon YH, Jung YK, Arrowsmith CH, Avvakumov GV, Dhe-Paganon S, Yoo YJ, Eom SH, Lee W., Free PMC Article | 02/26/2011 |
| The expression a mutant human UBB analogous (UB14) in yeast markedly enhanced cellular susceptibility to toxic protein aggregates. | Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
Tank EM, True HL., Free PMC Article | 01/21/2010 |
| analyse the expression of mutant ubiquitin (UBB+1), in muscle biopsies from patients suffering from myotilinopathy and desminopathy | Expression of mutant ubiquitin (UBB+1) and p62 in myotilinopathies and desminopathies.
Olivé M, van Leeuwen FW, Janué A, Moreno D, Torrejón-Escribano B, Ferrer I. | 01/21/2010 |