| BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis. | BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis.
Garritson JD, Zhang J, Achenbach A, Ferhat M, Eich E, Stubben CJ, Martinez PL, Ibele AR, Hilgendorf KI, Boudina S., Free PMC Article | 06/22/2023 |
| BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype. | BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype.
Pankratz F, Maksudova A, Goesele R, Meier L, Proelss K, Marenne K, Thut AK, Sengle G, Correns A, Begelspacher J, Alkis D, Siegel PM, Smolka C, Grundmann S, Moser M, Zhou Q, Esser JS., Free PMC Article | 03/14/2023 |
| BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway. | BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway.
Ding P, Chen W, Yan X, Zhang J, Li C, Zhang G, Wang Y, Li Y., Free PMC Article | 05/14/2022 |
| BMPER is upregulated in obesity and seems to have a role in pericardial adipose stem cells. | BMPER is upregulated in obesity and seems to have a role in pericardial adipose stem cells.
Pérez LM, de Lucas B, Gálvez BG. | 09/4/2021 |
| Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. | Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance.
Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X., Free PMC Article | 04/17/2021 |
| BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment. | A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
McGarvey AC, Rybtsov S, Souilhol C, Tamagno S, Rice R, Hills D, Godwin D, Rice D, Tomlinson SR, Medvinsky A., Free PMC Article | 12/23/2017 |
| CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. | Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells.
Jumabay M, Zhumabai J, Mansurov N, Niklason KC, Guihard PJ, Cubberly MR, Fogelman AM, Iruela-Arispe L, Yao Y, Saparov A, Boström KI., Free PMC Article | 12/16/2017 |
| BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. | LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation.
Lockyer P, Mao H, Fan Q, Li L, Yu-Lee LY, Eissa NT, Patterson C, Xie L, Pi X., Free PMC Article | 08/12/2017 |
| The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. | Fibroblast growth factor signaling pathway in endothelial cells is activated by BMPER to promote angiogenesis.
Esser JS, Rahner S, Deckler M, Bode C, Patterson C, Moser M. | 03/28/2015 |
| BMPER-induced BMP signaling promotes coronary artery remodeling. | BMPER-induced BMP signaling promotes coronary artery remodeling.
Dyer L, Wu Y, Moser M, Patterson C., Free PMC Article | 03/29/2014 |
| BMPER appears to play a role in regulating both vessel density and cardiac development | BMPER regulates cardiomyocyte size and vessel density in vivo.
Willis MS, Dyer LA, Ren R, Lockyer P, Moreno-Miralles I, Schisler JC, Patterson C., Free PMC Article | 12/14/2013 |
| BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin and epithelial leakage in vitro and in vivo. | Inhibition of BMP activity protects epithelial barrier function in lung injury.
Helbing T, Herold EM, Hornstein A, Wintrich S, Heinke J, Grundmann S, Patterson C, Bode C, Moser M. | 10/19/2013 |
| Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. | Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.
Pi X, Lockyer P, Dyer LA, Schisler JC, Russell B, Carey S, Sweet DT, Chen Z, Tzima E, Willis MS, Homeister JW, Moser M, Patterson C., Free PMC Article | 11/3/2012 |
| The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. | Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior.
Heinke J, Kerber M, Rahner S, Mnich L, Lassmann S, Helbing T, Werner M, Patterson C, Bode C, Moser M., Free PMC Article | 09/1/2012 |
| Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. | BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice.
Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada GO, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry RR, Hughes RD, Dhawan A, Patterson C, Simpson RJ, McKie AT., Free PMC Article | 03/31/2012 |
| BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. | BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.
Helbing T, Rothweiler R, Ketterer E, Goetz L, Heinke J, Grundmann S, Duerschmied D, Patterson C, Bode C, Moser M. | 01/14/2012 |
| BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina. | Bone morphogenetic protein endothelial cell precursor-derived regulator regulates retinal angiogenesis in vivo in a mouse model of oxygen-induced retinopathy.
Moreno-Miralles I, Ren R, Moser M, Hartnett ME, Patterson C., Free PMC Article | 11/12/2011 |
| The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. | Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.
Zakin L, Chang EY, Plouhinec JL, De Robertis EM., Free PMC Article | 11/27/2010 |
| Cv2 enhances pro-BMP activity of Tsg. | Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.
Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y. | 03/1/2010 |
| Study demonstrates that as molar concentrations of Bmper exceed Bmp4, Bmper dynamically switches from an activator to an inhibitor of Bmp4 signaling. | A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.
Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C., Free PMC Article | 01/21/2010 |
| Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. | Crossveinless-2 controls bone morphogenetic protein signaling during early cardiomyocyte differentiation in P19 cells.
Harada K, Ogai A, Takahashi T, Kitakaze M, Matsubara H, Oh H., Free PMC Article | 01/21/2010 |
| Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. | Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.
Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM., Free PMC Article | 01/21/2010 |
| The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. | Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice.
Ikeya M, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y. | 01/21/2010 |
| crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. | Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. | 01/21/2010 |
| Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. | Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade.
Kamimura M, Matsumoto K, Koshiba-Takeuchi K, Ogura T. | 01/21/2010 |