| FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells. | FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.
Han D, Guan L, Zhang Y, Yang H, Si L, Jia T, Wu Y, Lv K, Song T, Yang G. | 09/18/2023 |
| UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia. | UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.
Duployez N, Vasseur L, Kim R, Largeaud L, Passet M, L'Haridon A, Lemaire P, Fenwarth L, Geffroy S, Helevaut N, Celli-Lebras K, Adès L, Lebon D, Berthon C, Marceau-Renaut A, Cheok M, Lambert J, Récher C, Raffoux E, Micol JB, Pigneux A, Gardin C, Delabesse E, Soulier J, Hunault M, Dombret H, Itzykson R, Clappier E, Preudhomme C., Free PMC Article | 06/13/2023 |
| UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome. | UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome.
Georgi JA, Stasik S, Eckardt JN, Zukunft S, Hartwig M, Röllig C, Middeke JM, Oelschlägel U, Krug U, Sauer T, Scholl S, Hochhaus A, Brümmendorf TH, Naumann R, Steffen B, Einsele H, Schaich M, Burchert A, Neubauer A, Schäfer-Eckart K, Schliemann C, Krause SW, Hänel M, Noppeney R, Kaiser U, Baldus CD, Kaufmann M, Müller-Tidow C, Platzbecker U, Berdel WE, Serve H, Ehninger G, Bornhäuser M, Schetelig J, Kroschinsky F, Thiede C, Study Alliance Leukemia (SAL)., Free PMC Article | 05/30/2023 |
| UBTF-internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia. | UBTF-internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia.
Kaburagi T, Shiba N, Yamato G, Yoshida K, Tabuchi K, Ohki K, Ishikita E, Hara Y, Shiraishi Y, Kawasaki H, Sotomatsu M, Takizawa T, Taki T, Kiyokawa N, Tomizawa D, Horibe K, Miyano S, Taga T, Adachi S, Ogawa S, Hayashi Y. | 02/14/2023 |
| Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL. | Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.
Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay T, Hunault M, Pflumio F, Freund JN, Lobry C, Lhéritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E., Free PMC Article | 06/25/2022 |
| Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia. | Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia.
Kimura S, Montefiori L, Iacobucci I, Zhao Y, Gao Q, Paietta EM, Haferlach C, Laird AD, Mead PE, Gu Z, Stock W, Litzow M, Rowe JM, Luger SM, Hunger SP, Ryland GL, Schmidt B, Ekert PG, Oshlack A, Grimmond SM, Rehn J, Breen J, Yeung D, White DL, Aldoss I, Jabbour EJ, Pui CH, Meggendorfer M, Walter W, Kern W, Haferlach T, Brady S, Zhang J, Roberts KG, Blombery P, Mullighan CG., Free PMC Article | 06/25/2022 |
| Protein kinase Ciota promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells. | Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.
Justilien V, Lewis KC, Meneses KM, Jamieson L, Murray NR, Fields AP., Free PMC Article | 01/2/2021 |
| These results demonstrate the role of pNO40 in ribosomal RNA biosynthesis regulation by compromising UBF function in ribosomal DNA transcription activation with subsequent ribosomal RNA synthesis inhibition. | Ectopically expressed pNO40 suppresses ribosomal RNA synthesis by inhibiting UBF-dependent transcription activation.
Lin YM, Chu PH, Ouyang P. | 07/4/2020 |
| mutant SEC23B binds to UBF transcription factor, with increased UBF transcription factor binding at the ribosomal DNA promoter. Our data indicate SEC23B has potential non-canonical COPII-independent function, particularly within the ribosome biogenesis pathway, and that may contribute to the pathogenesis of cancer-predisposition. | Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway.
Yehia L, Jindal S, Komar AA, Eng C., Free PMC Article | 03/16/2019 |
| Data underscore the importance of including UBTF E210K in the differential diagnosis of neuroregression and suggest that mainly gain-of-function mechanisms contribute to the pathogenesis of the UBTF E210K neuroregression syndrome. | A recurrent de novo missense mutation in UBTF causes developmental neuroregression.
Toro C, Hori RT, Malicdan MCV, Tifft CJ, Goldstein A, Gahl WA, Adams DR, Fauni HB, Wolfe LA, Xiao J, Khan MM, Tian J, Hope KA, Reiter LT, Tremblay MG, Moss T, Franks AL, Balak C, C4RCD Research Group, LeDoux MS., Free PMC Article | 01/12/2019 |
| TP53INP2 promotes ribosome biogenesis through facilitating rRNA synthesis at the nucleolus | TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters.
Xu Y, Wan W, Shou X, Huang R, You Z, Shou Y, Wang L, Zhou T, Liu W., Free PMC Article | 01/20/2018 |
| Study demonstrated that HMG box 1, the linker region between the HMG boxes and C-terminal acidic region (AR), and the AR cooperatively regulate the nucleolar localization of UBF. | Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization.
Ueshima S, Nagata K, Okuwaki M., Free PMC Article | 11/18/2017 |
| In seven unrelated affected individuals, all suffering from developmental regression starting at 2.5-7 years, the authors identified a heterozygous variant, c.628G>A in UBTF, encoding p.Glu210Lys in UBF, which occurred de novo in all cases. | Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood.
Edvardson S, Nicolae CM, Agrawal PB, Mignot C, Payne K, Prasad AN, Prasad C, Sadler L, Nava C, Mullen TE, Begtrup A, Baskin B, Powis Z, Shaag A, Keren B, Moldovan GL, Elpeleg O., Free PMC Article | 09/9/2017 |
| RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. | RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription.
Yang CP, Kuo YL, Lee YC, Lee KH, Chiang CW, Wang JM, Hsu CC, Chang WC, Lin DY. | 05/20/2017 |
| This study provides some compelling evidences in support of HBx-elicited and c-Myc-mediated increase in UBF levels that abets oncogenic onslaught in hepatic cells by increasing rDNA transcription and ribosome biogenesis. | The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF.
Rajput P, Shukla SK, Kumar V., Free PMC Article | 01/23/2016 |
| These results suggest that UBF can inhibit gene expression from viral DNA prior to its replication. | Upstream binding factor inhibits herpes simplex virus replication.
Ouellet Lavallée G, Pearson A. | 10/17/2015 |
| we have uncovered a novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity). | A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, Cameron DP, Ellul J, Goodall GJ, Wong LH, Dhillon AS, Hamdane N, Rothblum LI, Pearson RB, Haviv I, Moss T, Hannan RD., Free PMC Article | 09/26/2015 |
| p14ARF fails to prevent E7-mediated UBF1 phosphorylation, but could facilitate nucleolar pRb inactivation by targeting E7 to the nucleolus. | Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF.
Dichamp I, Séité P, Agius G, Barbarin A, Beby-Defaux A., Free PMC Article | 06/20/2015 |
| PIP2 depletion reduces Pol I transcription. | Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription.
Yildirim S, Castano E, Sobol M, Philimonenko VV, Dzijak R, Venit T, Hozák P. | 03/1/2014 |
| UBF is expressed widely by human multiple fetal tissue,s and the expression level is very high in HL-60 cells. | [Expression profiling of UBF, a novel member of UBC family].
Cui CP, Zhang Y, Yu YT, Li YZ, Geng Y, Zhao SF. | 12/22/2012 |
| Downregulation of RUNX2 expression reduces the localization of HDAC1 to the nucleolar periphery and also decreases the association between HDAC1 and UBF. | A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation.
Ali SA, Dobson JR, Lian JB, Stein JL, van Wijnen AJ, Zaidi SK, Stein GS., Free PMC Article | 12/22/2012 |
| hALP binds the upstream binding factor (UBF) in vivo and in vitro | hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF).
Kong R, Zhang L, Hu L, Peng Q, Han W, Du X, Ke Y., Free PMC Article | 05/7/2011 |
| depletion of upstream binding factor (UBF; an rRNA transcription factor) decreased the chromatin binding affinity of B23, which in turn led to an increase in histone density at the r-chromatin | Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF.
Hisaoka M, Ueshima S, Murano K, Nagata K, Okuwaki M., Free PMC Article | 10/30/2010 |
| these results implicate a fluid helix-turn-helix folding model of hUBF Box-5. | Temperature-induced partially unfolded state of hUBF HMG Box-5: conformational and dynamic investigations of the Box-5 thermal intermediate ensemble.
Liu Z, Zhang J, Wang X, Ding Y, Wu J, Shi Y. | 01/21/2010 |
| The established differential localization of UBF in nucleoli of HeLa cells has a functional meaning. It reflects both the level of rRNA synthesis activities and the architectural role of UBF in nucleoli of these cells. | Nucleolar localization of upstream binding factor in HeLa cells depends on rRNA synthesis activities.
He J, Wu X, Tao W. | 01/21/2010 |