| Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. | Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action.
Sarfstein R, Nagaraj K, Parikh S, Levy C, Laron Z, Benayahu D, Werner H., Free PMC Article | 06/11/2022 |
| Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells. | Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.
Shafiee-Kermani F, Carney ST, Jima D, Utin UC, Farrar LB, Oputa MO, Hines MR, Kinyamu HK, Trotter KW, Archer TK, Hoyo C, Koller BH, Freedland SJ, Grant DJ., Free PMC Article | 01/15/2022 |
| Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells. | Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells.
Yu D, Chen J, Chen S, Xu L, Wu L, Li D, Luo J, Jin Y, Zhao Y, Knox B, Tolleson WH, Wang X, Guo L, Tong W, Ning B., Free PMC Article | 07/24/2021 |
| Novel associations between the UGT polymorphisms and EEDs concentrations in patients with PCOS, supporting the relevance of genetic differences in EEDs metabolism, which might be considered as an etiology of PCOS. | The correlation between UDP-glucuronosyltransferase polymorphisms and environmental endocrine disruptors levels in polycystic ovary syndrome patients.
Luo Y, Nie Y, Tang L, Xu CC, Xu L., Free PMC Article | 03/28/2020 |
| Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells | Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites.
Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R. | 06/1/2019 |
| High UGT2B15 expression is associated with the pathogenesis of gastric cancer. | Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer.
Chen X, Li D, Wang N, Yang M, Liao A, Wang S, Hu G, Zeng B, Yao Y, Liu D, Liu H, Zhou W, Xiao W, Li P, Ming C, Ping S, Chen P, Jing L, Bai Y, Yao J., Free PMC Article | 11/24/2018 |
| This study showed that UGT2B7 and UGT2B15 3'-UTRs contain miRNA response elements for multiple miRNAs that may contribute to variable drug glucuronidation. | Identification and validation of the microRNA response elements in the 3'-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach.
Papageorgiou I, Court MH., Free PMC Article | 12/16/2017 |
| Results found no significant increased risk for benign prostatic hyperplasia (BPH) in men with low activity genotype at D85Y, but found rather, a significant association between UGT2B15 D85Y and BPH risk when it is in combination with the UGT2B17 copy number variation. | Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.
Habibi M, Mirfakhraie R, Khani M, Rakhshan A, Azargashb E, Pouresmaeili F. | 10/7/2017 |
| Our findings highlight the influence of UGTT1A4 haplotypes on tamoxifen disposition in Asian breast cancer patients, while genetic variants in UGT2B7 and UGT2B15 appear to be of minor importance. | Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients.
Sutiman N, Lim JSL, Muerdter TE, Singh O, Cheung YB, Ng RCH, Yap YS, Wong NS, Ang PCS, Dent R, Schroth W, Schwab M, Khor CC, Chowbay B. | 09/16/2017 |
| the UGT2B15 and UGT2B17 enzymes are transcriptionally regulated by sex hormone signaling in ERalpha+ breast cancer cells and are highly expressed in a subset of primary breast cancers. | Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.
Hu DG, Selth LA, Tarulli GA, Meech R, Wijayakumara D, Chanawong A, Russell R, Caldas C, Robinson JL, Carroll JS, Tilley WD, Mackenzie PI, Hickey TE. | 08/5/2017 |
| UGT2B15 genotype contributes to postoperative anxiety reduction after lorazepam premedication. | Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication.
Mijderwijk H, Klimek M, van Beek S, van Schaik RH, Duivenvoorden HJ, Stolker RJ. | 07/1/2017 |
| Report frequency of UGT2B15 genetic polymorphisms in Pakistani population and genotype/phenotype correlation for glucuronidation of paracetamol. | Genetic polymorphism of UDP-glucuronosyltransferase (UGT2B15) and glucuronidation of paracetamol in healthy population.
Mehboob H, Iqbal T, Jamil A, Khaliq T. | 01/14/2017 |
| CYP3A4, CYP3A7, UGT2B11 and UGT2B15 genes are significantly downregulated in melanosis coli. | Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
Li XΑ, Zhou Y, Zhou SΧ, Liu HR, Xu JM, Gao L, Yu XJ, Li XH., Free PMC Article | 06/28/2016 |
| This descriptive study examines correlations between concentrations of tamoxifen's glucuronide metabolites and genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 in 132 patients with estrogen receptor-positive breast cancer under treatment with tamoxifen | Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients.
Romero-Lorca A, Novillo A, Gaibar M, Bandrés F, Fernández-Santander A., Free PMC Article | 05/7/2016 |
| miR-376c is inversely linked to UGT2B15 and UGT2B17 expression in high-grade prostate cancer and metastasis.UGT2B15 and UGT2B17 genes are direct targets of miR-376c and thus may influence steroid metabolism during prostate cancer progression. | Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.
Margaillan G, Lévesque É, Guillemette C. | 05/7/2016 |
| Data suggest that both 17beta-estradiol and the antiestrogen 4-OHTAM (4-hydroxytamoxifen, a metabolite of tamoxifen and substrate of UGT2B15) up-regulate UGT2B15 in breast cancer cells via the same estrogen receptor alpha- (ERa-)signaling pathway. | Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.
Chanawong A, Hu DG, Meech R, Mackenzie PI, McKinnon RA. | 01/30/2016 |
| Hepatic UGT2B15 protein onset begins in late gestation; however, the greatest rate of change occurs during the first few weeks after birth. | Human hepatic UGT2B15 developmental expression.
Divakaran K, Hines RN, McCarver DG., Free PMC Article | 10/24/2015 |
| Expression of UGT2B15 and UGT2B17 is negatively regulated by the binding of miR-376c. | Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.
Wijayakumara DD, Hu DG, Meech R, McKinnon RA, Mackenzie PI. | 10/10/2015 |
| UGT2B15 genotype is a major determinant for differences in fasting plasma glucose and HbA1c response to sipoglitazar treatment between Type 2 Diabetes mellitus patients, due to related differences in drug exposure. | A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar.
Stringer F, DeJongh J, Scott G, Danhof M. | 11/8/2014 |
| A haplotype in UGT2B15 containing a functional variant (rs4148269, K523T) and an intronic SNP (rs6837575) was found to affect rectal cancer risk overall (OR = 2.57, 95% CI = 1.21-5.04) and in females (OR = 3.08, 95% CI = 1.08-8.74). | The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene–environment interactions.
Angstadt AY, Hartman TJ, Lesko SM, Muscat JE, Zhu J, Gallagher CJ, Lazarus P., Free PMC Article | 10/11/2014 |
| In the tamoxifen-treated subgroup poor prognosis was related to the combined presence of ESR1 PvuII wt/wt and UGT2B15 wt/wt or wt/*2 genotype. | Prognostic significance of ESR1 amplification and ESR1 PvuII, CYP2C19*2, UGT2B15*2 polymorphisms in breast cancer patients.
Markiewicz A, Wełnicka-Jaśkiewicz M, Skokowski J, Jaśkiewicz J, Szade J, Jassem J, Zaczek AJ., Free PMC Article | 05/3/2014 |
| Novel associations between UGT2B15 and UGT2B17 single nucleotide polymorphism variants and prostate cancer risk. | Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.
Vidal AC, Tucker C, Schildkraut JM, Richardson RM, McPhail M, Freedland SJ, Hoyo C, Grant DJ., Free PMC Article | 03/22/2014 |
| UGT2B15 is a possible target for androgen deprivation therapy of prostate cancer. | Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.
Grosse L, Pâquet S, Caron P, Fazli L, Rennie PS, Bélanger A, Barbier O. | 03/1/2014 |
| Report the influence of functionally relevant polymorphic UGT2B15, the enzyme mediating bisphenol A metabolism using kinetic based modelling. | Functional UDP-glucuronyltransferase 2B15 polymorphism and bisphenol A concentrations in blood: results from physiologically based kinetic modelling.
Partosch F, Mielke H, Gundert-Remy U. | 10/19/2013 |
| Sipoglitazar clearance is substantially modified by UGT2B15 enzyme variants, with higher exposure observed in the UGT2B15*2/*2 genotype group. | The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent.
Stringer F, Scott G, Valbuena M, Kinley J, Nishihara M, Urquhart R. | 08/3/2013 |