| SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer. | SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer.
Ji J, Xie M, Qian Q, Xu Y, Shi W, Chen Z, Ren D, Liu W, He X, Lv M, Ma J, Liu W, Li A, Liu B. | 01/15/2022 |
| High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma | High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.
Lemay AM, Courtemanche O, Couttas TA, Jamsari G, Gagné A, Bossé Y, Joubert P, Don AS, Marsolais D., Free PMC Article | 06/27/2020 |
| UGT8 is a potential prognostic indicator and druggable target of basal-like breast cancer. | Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.
Cao Q, Chen X, Wu X, Liao R, Huang P, Tan Y, Wang L, Ren G, Huang J, Dong C., Free PMC Article | 06/23/2019 |
| An increase in the immunolabelling of ceramide was observed in cells where UDP glycosyltransferase 8 (UGT8) was down-regulated as opposed to cells where UGT8 was either not regulated or was up-regulated. | Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism.
Al-Mahrouki A, Giles A, Hashim A, Kim HC, El-Falou A, Rowe-Magnus D, Farhat G, Czarnota GJ., Free PMC Article | 10/28/2017 |
| Data indicate that ceramide galactosyltransferase (UGT8), although enhanced in non-small cell lung carcinoma (NSCLC) tissues, does not meet the criteria of a lung tumor marker. | Expression of Ceramide Galactosyltransferase (UGT8) in Primary and Metastatic Lung Tissues of Non-Small-Cell Lung Cancer.
Rzechonek A, Cygan M, Blasiak P, Muszczynska-Bernhard B, Bobek V, Lubicz M, Adamiak J. | 09/23/2017 |
| Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners. | Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2.
Okahara K, Kizuka Y, Kitazume S, Ota F, Nakajima K, Hirabayashi Y, Maekawa M, Yoshikawa T, Taniguchi N. | 05/16/2015 |
| A new role was identified for UGT8 as a modulator of bile acid homeostasis. | A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.
Meech R, Mubarokah N, Shivasami A, Rogers A, Nair PC, Hu DG, McKinnon RA, Mackenzie PI. | 03/21/2015 |
| High expression of UGT8 accompanied by accumulation of GalCer in MDA-MB-231 cells is associated with a much higher proliferative index and a lower number of apoptotic cells in comparison to the MDA/LUC-shUGT8 cells. | Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.
Owczarek TB, Suchanski J, Pula B, Kmiecik AM, Chadalski M, Jethon A, Dziegiel P, Ugorski M., Free PMC Article | 09/6/2014 |
| Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population. | Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population.
Park H, Lee S, Kim HJ, Ju YS, Shin JY, Hong D, von Grotthuss M, Lee DS, Park C, Kim JH, Kim B, Yoo YJ, Cho SI, Sung J, Lee C, Kim JI, Seo JS., Free PMC Article | 06/15/2013 |
| UGT8 is a significant index of tumour aggressiveness and is seen in lung metastases of breast cancer. | Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.
Dzięgiel P, Owczarek T, Plazuk E, Gomułkiewicz A, Majchrzak M, Podhorska-Okołów M, Driouch K, Lidereau R, Ugorski M., Free PMC Article | 09/6/2010 |
| Gene expression of galactosyl ceramide synthase associated with poor pathohistological grading in breast cancer | Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Ruckhäberle E, Karn T, Rody A, Hanker L, Gätje R, Metzler D, Holtrich U, Kaufmann M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesA systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR, CPNDS Consortium. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. | 04/29/2009 |
| We postulate that molecular link between defective GALT enzyme, which result in classic galactosemia and the cerebroside galactosyl transferase, responsible for galactosylation of cerebrosides, is dependent on concentrations of UDP-galactose. | The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia.
Lebea PJ, Pretorius PJ. | 01/21/2010 |
| Single-nucleotide polymorphisms (SNPs) were found in UGT8 gene | Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.
Iida A, Saito S, Sekine A, Mishima C, Kitamura Y, Kondo K, Harigae S, Osawa S, Nakamura Y. | 01/21/2010 |
| the GC-box and CRE function cooperatively, and that the CRE regulates the cell-specific expression of the hCGT gene | Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE.
Tencomnao T, Kapitonov D, Bieberich E, Yu RK. | 01/21/2010 |