| Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. | Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.
de la Aleja AG, Herrero C, Torres-Torresano M, Schiaffino MT, Del Castillo A, Alonso B, Vega MA, Puig-Kröger A, Castrillo A, Corbí ÁL., Free PMC Article | 04/19/2023 |
| Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner. | Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.
Shavva VS, Babina AV, Nekrasova EV, Lisunov AV, Dizhe EB, Oleinikova GN, Orlov SV. | 02/23/2023 |
| Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. | Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.
Kim J, Lee H, Lee JE, Choi G, Chung H, Kim D, Park MJ, Gye YS, Shin KS, Kang CY, Kwok SK, Chung Y., Free PMC Article | 02/23/2023 |
| CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1. | CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.
Liang Z, Jiao W, Wang L, Chen Y, Li D, Zhang Z, Zhang Z, Liang Y, Niu H. | 09/10/2022 |
| MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase. | MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
Izumi A, Hiraguchi H, Kodaka M, Ikeuchi E, Narita J, Kobayashi R, Matsumoto Y, Suzuki T, Yamamoto Y, Sato R, Inoue J. | 11/22/2021 |
| Liver X receptor inhibits the growth of hepatocellular carcinoma cells via regulating HULC/miR-134-5p/FOXM1 axis. | Liver X receptor inhibits the growth of hepatocellular carcinoma cells via regulating HULC/miR-134-5p/FOXM1 axis.
He J, Yang T, He W, Jiang S, Zhong D, Xu Z, Wei Q, Zhang Y, Shi C. | 10/23/2021 |
| Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRbeta as the Functional Target of Enhancers of Astrocytic apoE. | Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.
Seneviratne U, Huang Z, Am Ende CW, Butler TW, Cleary L, Dresselhaus E, Evrard E, Fisher EL, Green ME, Helal CJ, Humphrey JM, Lanyon LF, Marconi M, Mukherjee P, Sciabola S, Steppan CM, Sylvain EK, Tuttle JB, Verhoest PR, Wager TT, Xie L, Ramaswamy G, Johnson DS, Pettersson M. | 09/4/2021 |
| Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer. | Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer.
Shao W, Kuhn C, Mayr D, Ditsch N, Kailuwait M, Wolf V, Harbeck N, Mahner S, Jeschke U, Cavaillès V, Sixou S., Free PMC Article | 08/21/2021 |
| LXRbeta is involved in the control of platelet production from megakaryocytes. | LXRβ is involved in the control of platelet production from megakaryocytes.
Wan YW, Liu W, Feng MT, Pu J, Zhuang SW, He B, Liu X. | 08/14/2021 |
| Liver X Receptor beta Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer. | Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer.
Jeong S, Kim IK, Kim H, Choi MJ, Lee J, Jo YS., Free PMC Article | 07/31/2021 |
| LXRbeta controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1. | LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1.
Patel D, Ahmad F, Kambach DM, Sun Q, Halim AS, Kramp T, Camphausen KA, Stommel JM., Free PMC Article | 11/21/2020 |
| LXRalpha-mediated downregulation of EGFR suppress colorectal cancer cell proliferation. | LXRα-mediated downregulation of EGFR suppress colorectal cancer cell proliferation.
Liang X, Cao Y, Xiang S, Xiang Z. | 09/19/2020 |
| Cholestenoic acid analogues as inverse agonists of the liver X receptors. | Cholestenoic acid analogues as inverse agonists of the liver X receptors.
Alvarez LD, Dansey MV, Ogara MF, Peña CI, Houtman R, Veleiro AS, Pecci A, Burton G. | 08/15/2020 |
| In skin biopsies of T2DM patients, a significant reduction in LXR expression and increase in Nox4 expression and activity appears in Schwann cells and peripheral nerves. | Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice.
Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA, Massaad C. | 08/12/2020 |
| Liver X receptor activation reduces gastric cancer cell proliferation by suppressing Wnt signaling via LXR-beta relocalization. | Liver X receptor activation reduces gastric cancer cell proliferation by suppressing Wnt signalling via LXRβ relocalization.
Wang Q, Feng F, Wang J, Ren M, Shi Z, Mao X, Zhang H, Ju X., Free PMC Article | 06/20/2020 |
| expression levels of two LXR target genes, LXRalpha and LXRbeta, were lower in high-plaque tissues than in low-plaque tissues | Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.
Chen J, Zhang D, Ji MF, Liu T, Mei CL, Tang XJ. | 05/30/2020 |
| No significant differences were identified between the expression levels of LXRbeta in the triplenegative breast cancer tissues compared with the noncancerous mammary tissues. | Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues.
Pan H, Zheng Y, Pan Q, Chen H, Chen F, Wu J, Di D., Free PMC Article | 02/29/2020 |
| UNR could bind to the 3'UTR of PTEN and RPL9 in glioma cell lines, therefore promoting glioma cell migration and regulating the expression of RPL9. | RNA-binding Protein UNR Promotes Glioma Cell Migration and Regulates the Expression of Ribosomal Protein L9.
Tian NY, Qi YJ, Hu Y, Yin B, Yuan JG, Qiang BQ, Peng XZ, Han W. | 08/17/2019 |
| The authors report that, in Mycobacterium tuberculosis-infected macrophages, IL-36 signaling modulates cholesterol biosynthesis and efflux via LXR. | IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.
Ahsan F, Maertzdorf J, Guhlich-Bornhof U, Kaufmann SHE, Moura-Alves P., Free PMC Article | 12/22/2018 |
| The results suggest that in gestational diabetes mellitus cellular cholesterol homeostasis in the fetoplacental endothelium is modulated via LXR activation and helps to maintain its proper functionality. | Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium.
Sun Y, Kopp S, Strutz J, Gali CC, Zandl-Lang M, Fanaee-Danesh E, Kirsch A, Cvitic S, Frank S, Saffery R, Björkhem I, Desoye G, Wadsack C, Panzenboeck U. | 12/1/2018 |
| These findings provide basic information for evaluating the efficacy of LXR-targeted treatment in refractory carcinoma tissues of the human lung and pancreas | Expression of liver X receptors in normal and refractory carcinoma tissues of the human lung and pancreas.
Kashiwagi K, Yanagida M, Matsui D, Tanaka M, Sugimoto K, Chen H, Ichikawa-Tomikawa N, Marubashi S, Suzuki H, Chiba H. | 09/29/2018 |
| LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels. | Liver X Receptor Gene Expression is Enhanced in Children with Obstructive Sleep Apnea-Hyperpnoea Syndrome and Cyclooxygenase-2 (COX-2) is Correlated with Severity of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).
Ye XH, Chen H, Yu Q, Zhu QL., Free PMC Article | 03/31/2018 |
| ULK1 has a role in RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells | Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM., Free PMC Article | 12/9/2017 |
| These data suggest that high doses of insulin downregulate apoA-I gene expression in HepG2 cells through redistribution of FOXO1/LXRbeta complex, FOXA2, and LXRalpha on hepatic enhancer of apoA-I gene. | Insulin-Mediated Downregulation of Apolipoprotein A-I Gene in Human Hepatoma Cell Line HepG2: The Role of Interaction Between FOXO1 and LXRβ Transcription Factors.
Shavva VS, Bogomolova AM, Nikitin AA, Dizhe EB, Tanyanskiy DA, Efremov AM, Oleinikova GN, Perevozchikov AP, Orlov SV. | 11/4/2017 |
| Expression of some LXR-dependent genes of cholesterol trafficking is related to breast tumor characteristics, but not time to recurrence. | Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity.
Bobin-Dubigeon C, Chauvin A, Brillaud-Meflah V, Boiffard F, Joalland MP, Bard JM. | 10/21/2017 |