| PKCzeta phosphorylates VASP to mediate chemotaxis in breast cancer cells. | PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells.
Wang C, Zhao X, Zhao L, Wang Y, Jia Y, Zhang X, Ma W. | 01/3/2024 |
| Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells. | Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
Torres-Gomez A, Fiyouzi T, Guerra-Espinosa C, Cardeñes B, Clares I, Toribio V, Reche PA, Cabañas C, Lafuente EM., Free PMC Article | 10/22/2022 |
| Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge. | Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Skruber K, Warp PV, Shklyarov R, Thomas JD, Swanson MS, Henty-Ridilla JL, Read TA, Vitriol EA., Free PMC Article | 08/21/2021 |
| Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis. | Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis.
Liu LB, Jiang ZJ, Jiang XL, Wang S. | 03/20/2021 |
| RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment. | RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
Torres-Gomez A, Sanchez-Trincado JL, Toribio V, Torres-Ruiz R, Rodríguez-Perales S, Yáñez-Mó M, Reche PA, Cabañas C, Lafuente EM., Free PMC Article | 02/27/2021 |
| Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R., Free PMC Article | 01/16/2021 |
| Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma. | Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.
Huang F, Ma G, Zhou X, Zhu X, Yu X, Ding F, Cao X, Liu Z. | 12/12/2020 |
| Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8. | Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8.
Donhauser N, Socher E, Millen S, Heym S, Sticht H, Thoma-Kress AK., Free PMC Article | 10/24/2020 |
| ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation. | ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation.
Zhao T, Liang X, Chen J, Bao Y, Wang A, Gan X, Lu X, Wang L. | 07/11/2020 |
| this study highlights the important roles of BLACAT1/miR-605-3p/VASP axis in glioma progression. | LncRNA BLACAT1 regulates VASP expression via binding to miR-605-3p and promotes giloma development.
Liu N, Hu G, Wang H, Wang Y, Guo Z. | 06/13/2020 |
| findings indicate that integrin alpha3 interacts with VASP and regulates its expression | ITGA3 interacts with VASP to regulate stemness and epithelial-mesenchymal transition of breast cancer cells.
Zhang H, Cui X, Cao A, Li X, Li L. | 03/7/2020 |
| We found that VASP's interaction with Pfn1 is promoted by cell-substrate adhesion and requires down-regulation of PKA activity | The VASP-profilin1 (Pfn1) interaction is critical for efficient cell migration and is regulated by cell-substrate adhesion in a PKA-dependent manner.
Gau D, Veon W, Shroff SG, Roy P., Free PMC Article | 01/11/2020 |
| these results indicated that SSb2 may be a potential antitumor drug for the treatment of breast cancer, which acts by suppressing proliferation and migration by downregulating the STAT3 signalling pathway and inhibiting the expression of VASP, MMP2 and MMP9 expression. | Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.
Ma Q, Gao FF, He X, Li K, Gao Y, Xu XL, Jiang NH, Ding L, Song WJ, He YQ, Pan WT, Wei L, Zhang JW. | 12/28/2019 |
| Taken together, these results defined VASP as an oncogene of hepatocellular carcinoma pathogenesis and metastasis with the potential to serve as a prognostic biomarker. | Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma.
Liu Z, Wang Y, Dou C, Xu M, Sun L, Wang L, Yao B, Li Q, Yang W, Tu K, Liu Q., Free PMC Article | 09/7/2019 |
| Our results demonstrate a novel requirement for VASP and actin polymerization in maintaining lytic granule convergence during NK cell-mediated killing. | VASP Regulates NK Cell Lytic Granule Convergence.
Wilton KM, Billadeau DD., Free PMC Article | 07/20/2019 |
| Study results demonstrated that TNFalpha decreased VASP expression by upregulating the expression of HIF1alpha to inhibit A549 cell proliferation and adhesion. Inhibition of transplanted tumor growth was associated with downregulation of VASP expression in nude mice. Bioinformatics analysis indicated that expression levels of VASP or HIF1alpha lead to differential outcomes of overall survival in lung carcinoma. | TNF‑α inhibits xenograft tumor formation by A549 lung cancer cells in nude mice via the HIF‑1α/VASP signaling pathway.
Liu W, Chen X, He Y, Tian Y, Xu L, Ma Y, Hu P, Su K, Luo Z, Wei L, Zhang J. | 06/29/2019 |
| Silencing of stathmin-1 altered the expression, subcellular localization and phosphorylation status of VASP, which suggested that it might be associated with remodeling of the cell cytoskeleton in colorectal cancer metastasis. | Label-Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator-Stimulated Phosphoprotein upon Stathmin-1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines.
Tan HT, Chung MCM. | 05/4/2019 |
| VASP may be involved in the pathophysiology of bronchopulmonary dysplasia via dysregulation of actin binding proteins | Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD.
Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK., Free PMC Article | 01/5/2019 |
| VASP role in the actin filament elongation | Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays.
Brühmann S, Ushakov DS, Winterhoff M, Dickinson RB, Curth U, Faix J., Free PMC Article | 05/26/2018 |
| Our results reveal a dual role of VASP in endothelial permeability. In addition to its well-documented function in barrier integrity, we show that S-nitrosylation of VASP contributes to the onset of endothelial permeability. | S-nitrosylation of VASP at cysteine 64 mediates the inflammation-stimulated increase in microvascular permeability.
Zamorano P, Marín N, Córdova F, Aguilar A, Meininger C, Boric MP, Golenhofen N, Contreras JE, Sarmiento J, Durán WN, Sánchez FA., Free PMC Article | 08/19/2017 |
| findings have uncovered a PKG/VASP signaling pathway in Vascular Smooth Muscle Cells as a key molecular mechanism underlying T3-induced vascular relaxation. | Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling in Vascular Smooth Muscle Cells.
Samuel S, Zhang K, Tang YD, Gerdes AM, Carrillo-Sepulveda MA. | 06/24/2017 |
| This study provides the first evidence of VASP manipulation by an intravacuolar bacterial pathogen | Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages.
Colonne PM, Winchell CG, Graham JG, Onyilagha FI, MacDonald LJ, Doeppler HR, Storz P, Kurten RC, Beare PA, Heinzen RA, Voth DE., Free PMC Article | 06/3/2017 |
| VASP silencing downregulated Migfilin, beta-catenin and uPA and impaired spheroid invasion. | Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).
Gkretsi V, Stylianou A, Stylianopoulos T., Free PMC Article | 05/27/2017 |
| VASP phosphorylation assay could be useful in studies aimed at investigating relations between clopidogrel active metabolite bioavailability and clinical events. | Relationship between pharmacokinetics and pharmacodynamics of clopidogrel in patients undergoing percutaneous coronary intervention: comparison between vasodilator-stimulated phosphoprotein phosphorylation assay and multiple electrode aggregometry.
Danese E, Fava C, Beltrame F, Tavella D, Calabria S, Benati M, Gelati M, Gottardo R, Tagliaro F, Guidi GC, Cattaneo M, Minuz P. | 01/14/2017 |
| VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module. | VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.
Oldenburg J, van der Krogt G, Twiss F, Bongaarts A, Habani Y, Slotman JA, Houtsmuller A, Huveneers S, de Rooij J., Free PMC Article | 10/8/2016 |