| Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. | Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease.
Branciamore S, Gogoshin G, Rodin AS, Myers AJ., Free PMC Article | 07/10/2024 |
| Associations of VGF with Neuropathologies and Cognitive Health in Older Adults. | Associations of VGF with Neuropathologies and Cognitive Health in Older Adults.
Yu L, Petyuk VA, Lopes KP, Tasaki S, Menon V, Wang Y, Schneider JA, De Jager PL, Bennett DA., Free PMC Article | 07/28/2023 |
| Structure of AQEE-30 of VGF Neuropeptide in Membrane-Mimicking Environments. | Structure of AQEE-30 of VGF Neuropeptide in Membrane-Mimicking Environments.
Park OS, Bang JK, Cheong C, Jeon YH., Free PMC Article | 12/10/2022 |
| Neuronal survival factor VGF promotes chemoresistance and predicts poor prognosis in lung cancers with neuroendocrine feature. | Neuronal survival factor VGF promotes chemoresistance and predicts poor prognosis in lung cancers with neuroendocrine feature.
Yang LH, Lee RK, Kuo MH, Miao CC, Wang YX, Chen A, Jhu YW, Cheng HI, Pan ST, Chou YT. | 09/24/2022 |
| Low VGF is associated with executive dysfunction in patients with major depressive disorder. | Low VGF is associated with executive dysfunction in patients with major depressive disorder.
Ye Q, Zhang Y, Zhang Y, Chen Z, Yu C, Zheng C, Yu H, Zhou D, Li X. | 07/30/2022 |
| Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity. | Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
Koc G, Soyocak A, Alis H, Kankaya B, Kanigur G. | 05/29/2021 |
| Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease. | Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Beckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, Levey AI, Seyfried NT, Dammer EB, Duong D, Lah JJ, Haure-Mirande JV, Shackleton B, Fanutza T, Blitzer R, Kenny E, Zhu J, Haroutunian V, Katsel P, Gandy S, Tu Z, Ehrlich ME, Zhang B, Salton SR, Schadt EE., Free PMC Article | 09/26/2020 |
| Serum VGF levels were significantly lower in MDD patients but higher in BD patients compared with HC (both PTukey < 0.01). No correlation was found between serum VGF levels and any data of subjects. | Higher serum VGF protein levels discriminate bipolar depression from major depressive disorder.
Chen S, Jiang H, Hou Z, Yue Y, Zhang Y, Zhao F, Xu Z, Li Y, Mou X, Li L, Wang T, Zhao J, Han C, Sui Y, Wang M, Yang Z, Lu Y, Zhu Y, Li J, Shen X, Sun F, Chen Q, Yuan Y. | 07/25/2020 |
| H19 is a promising prognostic factor in Pancreatic neuroendocrine neoplasms (pNENs) with malignant behaviors and functions as an oncogene via the VGF-mediated PI3K/AKT/CREB pathway. In addition, our study implies that VGF may also serve as a candidate prognostic biomarker and therapeutic target in pNENs. | lncRNA H19 binds VGF and promotes pNEN progression via PI3K/AKT/CREB signaling.
Ji M, Yao Y, Liu A, Shi L, Chen D, Tang L, Yang G, Liang X, Peng J, Shao C. | 03/7/2020 |
| Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression. | Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.
Marwitz S, Heinbockel L, Scheufele S, Nitschkowski D, Kugler C, Perner S, Reck M, Ammerpohl O, Goldmann T., Free PMC Article | 07/14/2018 |
| results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene | Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms.
Behnke J, Cheedalla A, Bhatt V, Bhat M, Teng S, Palmieri A, Windon CC, Thakker-Varia S, Alder J., Free PMC Article | 06/3/2017 |
| We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity. | Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder.
Sabbagh U, Mullegama S, Wyckoff GJ., Free PMC Article | 12/24/2016 |
| Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels. | Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans.
Rahimi M, Vinciguerra M, Daghighi M, Özcan B, Akbarkhanzadeh V, Sheedfar F, Amini M, Mazza T, Pazienza V, Motazacker MM, Mahmoudi M, De Rooij FW, Sijbrands E, Peppelenbosch MP, Rezaee F., Free PMC Article | 08/13/2016 |
| Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma. | VGF Peptide Profiles in Type 2 Diabetic Patients' Plasma and in Obese Mice.
D'Amato F, Noli B, Angioni L, Cossu E, Incani M, Messana I, Manconi B, Solinas P, Isola R, Mariotti S, Ferri GL, Cocco C., Free PMC Article | 06/28/2016 |
| Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls. | VGF expression by T lymphocytes in patients with Alzheimer's disease.
Busse S, Steiner J, Glorius S, Dobrowolny H, Greiner-Bohl S, Mawrin C, Bommhardt U, Hartig R, Bogerts B, Busse M., Free PMC Article | 04/23/2016 |
| Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element | Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.
Moon SM, Kim JS, Park BR, Kim DK, Kim SG, Kim HJ, Chun HS, Lee BK, Kim CS. | 10/17/2015 |
| NERPs may be potent endogenous suppressors of glucose-dependent insulin secretion. | Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic β-cells.
Kim JW, Rhee M, Park JH, Yamaguchi H, Sasaki K, Minamino N, Nakazato M, Song DK, Yoon KH. | 09/17/2015 |
| DISC1 knockdown leads to a reduction of VGF in neurons. | Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR., Free PMC Article | 07/25/2015 |
| Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance. | Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF.
Sadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR., Free PMC Article | 06/27/2015 |
| We conclude that VGF contributes to survival and function of peripheral T cells | Age-related increase of VGF-expression in T lymphocytes.
Busse S, Steiner J, Micheel J, Dobrowolny H, Mawrin C, Krause TJ, Adamaszek M, Bogerts B, Bommhardt U, Hartig R, Busse M., Free PMC Article | 02/28/2015 |
| Among the 19 genes tested, VGF was found to be completely methylated in several Urothelial Cell Carcinoma cell lines | Epigenetic inactivation of VGF associated with Urothelial Cell Carcinoma and its potential as a non-invasive biomarker using urine.
Hayashi M, Bernert H, Kagohara LT, Maldonado L, Brait M, Schoenberg M, Bivalacqua T, Netto GJ, Koch W, Sidransky D, Hoque MO., Free PMC Article | 01/24/2015 |
| results indicate that VGF and PGP9.5 PH are potential biomarkers for ovarian carcinoma | Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression.
Brait M, Maldonado L, Noordhuis MG, Begum S, Loyo M, Poeta ML, Barbosa A, Fazio VM, Angioli R, Rabitti C, Marchionni L, de Graeff P, van der Zee AG, Wisman GB, Sidransky D, Hoque MO., Free PMC Article | 07/19/2014 |
| The expression of NPY and VGF was increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius in the brains of type-II diabetic patients. | NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diabetic patients.
Saderi N, Salgado-Delgado R, Avendaño-Pradel R, Basualdo Mdel C, Ferri GL, Chávez-Macías L, Roblera JE, Escobar C, Buijs RM., Free PMC Article | 03/30/2013 |
| [review] The vgf gene is induced in vivo by neurotrophins including nerve growth factor (NGF), brain derived growth factor (BDNF) and glial derived growth actor (GDNF), by synaptic activity and by homeostatic and other stimuli. | VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers.
Ferri GL, Noli B, Brancia C, D'Amato F, Cocco C. | 08/18/2012 |
| VGF is regulated by SOD1 and plays a critical role in motor neuron survival | An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.
Shimazawa M, Tanaka H, Ito Y, Morimoto N, Tsuruma K, Kadokura M, Tamura S, Inoue T, Yamada M, Takahashi H, Warita H, Aoki M, Hara H., Free PMC Article | 07/9/2011 |