VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis.
Wolf MM, Madden MZ, Arner EN, Bader JE, Ye X, Vlach L, Tigue ML, Landis MD, Jonker PB, Hatem Z, Steiner KK, Gaines DK, Reinfeld BI, Hathaway ES, Xin F, Tantawy MN, Haake SM, Jonasch E, Muir A, Weiss VL, Beckermann KE, Rathmell WK, Rathmell JC., Free PMC Article

VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
Lee H, Zhuang L, Gan B., Free PMC Article

Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.
Zhang C, Yu M, Hepperla AJ, Zhang Z, Raj R, Zhong H, Zhou J, Hu L, Fang J, Liu H, Liang Q, Jia L, Liao C, Xi S, Simon JM, Xu K, Liu Z, Nam Y, Kapur P, Zhang Q., Free PMC Article

VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.
Wang Z, Yan M, Ye L, Zhou Q, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B, Lu Z, Xu D., Free PMC Article

Does the VHL polymorphisms rs779805 and rs1642742 affect renal cell carcinoma susceptibility, prognosis and survival in Central European population?
Chrabańska M, Szweda-Gandor N, Drozdzowska B., Free PMC Article

[Activation of HIF-1α/ACLY signaling axis promotes progression of clear cell renal cell carcinoma with VHL inactivation mutation].
Ma Y, Wang YH, Huang S, Zou ZG, Hu L, Guo LC.

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.
Shen J, Zha Q, Yang QH, Zhou YQ, Liang X, Chen YJ, Qi GX, Zhang XJ, Yao WB, Gao XD, Chen S.,

Two Single Nucleotide Polymorphisms in the Von Hippel-Lindau Tumor Suppressor Gene in Patients with Clear Cell Renal Cell Carcinoma.
Chrabańska M, Szweda-Gandor N, Drozdzowska B., Free PMC Article

Clear cell mesotheliomas with inactivating VHL mutations and near-haploid genomic features.
Michal M, Kravtsov O, Ross JS, Skanderová D, Martínek P, Mosaieby E, Mata DA, Williams EA, Hung YP.

LncRNA MALAT1 promotes growth and metastasis of head and neck squamous cell carcinoma by repressing VHL through a non-canonical function of EZH2.
Duan Y, Yue K, Ye B, Chen P, Zhang J, He Q, Wu Y, Lai Q, Li H, Wu Y, Jing C, Wang X., Free PMC Article

High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.
Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H., Free PMC Article

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
Zhang S, Xu H, Li W, Ji J, Jin Q, Chen L, Gan Q, Tao Q, Chai Y., Free PMC Article

Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel-Lindau gene in the ccRCC.
Chesnel F, Jullion E, Delalande O, Couturier A, Alusse A, Le Goff X, Lenglet M, Gardie B, Abadie C, Arlot-Bonnemains Y., Free PMC Article

DDX41 expression is associated with tumor necrosis in clear cell renal cell carcinoma and in cooperation with VHL loss leads to worse prognosis.
Kobatake K, Ikeda K, Nakata Y, Yamasaki N, Kanai A, Sekino Y, Takemoto K, Fukushima T, Babasaki T, Kitano H, Goto K, Hayashi T, Sentani K, Teishima J, Kaminuima O, Hinata N.

An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer.
Artemov AV, Zhenilo S, Kaplun D, Starshin A, Sokolov A, Mazur AM, Szpotan J, Gawronski M, Modrzejewska M, Gackowski D, Prokhortchouk EB., Free PMC Article

Differential VHL Mutation Patterns in Bilateral Clear Cell RCC Distinguishes Between Independent Primary Tumors and Contralateral Metastatic Disease.
Vocke CD, Ricketts CJ, Metwalli AR, Pinto PA, Gautam R, Raffeld M, Merino MJ, Ball MW, Linehan WM., Free PMC Article

Comprehensive characterization of Alu-mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families.
Vocke CD, Ricketts CJ, Schmidt LS, Ball MW, Middelton LA, Zbar B, Linehan WM., Free PMC Article

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling.
Zhang X, Li S, He J, Jin Y, Zhang R, Dong W, Lin M, Yang Y, Tian T, Zhou Y, Xu Y, Lei QY, Zhang J, Zhang Q, Xu Y, Lv L.

iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
Zhao D, Zheng S, Wang X, Liu H, Zhao K, Li L, Hu Y.

Whole-Exome Sequencing Identifies the VHL Mutation (c.262T > C, p.Try88Arg) in Non-Obstructive Azoospermia-Associated Cystic Renal Cell Carcinoma.
Man Y, Shang X, Liu C, Zhang W, Huang Q, Ma S, Shiang R, Zhang F, Zhang L, Zhang Z., Free PMC Article

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions.
Mathó C, Fernández MC, Bonanata J, Liu XD, Martin A, Vieites A, Sansó G, Barontini M, Jonasch E, Coitiño EL, Pennisi PA., Free PMC Article

Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines.
Wang X, Hu J, Fang Y, Fu Y, Liu B, Zhang C, Feng S, Lu X., Free PMC Article

Investigation of VHL gene associated with miR-223 in clear cell renal cell carcinoma.
Unal U, Cecener G, Tezcan Unlu H, Aytac Vuruskan B, Efendi Erdem E, Egeli U, Ozturk Nazlioglu H, Kaygisiz O, Tunca B, Vuruskan H.

Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma.
Guo K, Wei Y, Wang Z, Zhang X, Zhang X, Liu X, Wu W, Wu Z, Zhang L, Cui CP., Free PMC Article

rs779805 Von Hippel-Lindau Gene Polymorphism Induced/Related Polycythemia Entity, Clinical Features, Cancer Association, and Familiar Characteristics.
Remenyi G, Bereczky Z, Gindele R, Ujfalusi A, Illes A, Udvardy M., Free PMC Article