| Stage-Specific L-Proline Uptake by Amino Acid Transporter Slc6a19/B[0]AT1 Is Required for Optimal Preimplantation Embryo Development in Mice. | Stage-Specific L-Proline Uptake by Amino Acid Transporter Slc6a19/B(0)AT1 Is Required for Optimal Preimplantation Embryo Development in Mice.
Treleaven T, Zada M, Nagarajah R, Bailey CG, Rasko JEJ, Morris MB, Day ML., Free PMC Article | 01/21/2023 |
| Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice. | Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice.
Cuny H, Bozon K, Kirk RB, Sheng DZ, Bröer S, Dunwoodie SL., Free PMC Article | 11/19/2022 |
| Absorption of essential amino acids is reduced significantly in the absence of SLC6A19, especially following a high-protein diet. | Mice Lacking the Intestinal and Renal Neutral Amino Acid Transporter SLC6A19 Demonstrate the Relationship between Dietary Protein Intake and Amino Acid Malabsorption.
Javed K, Bröer S., Free PMC Article | 02/15/2020 |
| analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin | Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
Fairweather SJ, Bröer A, Subramanian N, Tumer E, Cheng Q, Schmoll D, O'Mara ML, Bröer S., Free PMC Article | 01/16/2016 |
| Slc6a19 expression in the intestine is regulated at three different levels involving promoter methylation, histone modification, and opposing transcription factors. | Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks.
Tümer E, Bröer A, Balkrishna S, Jülich T, Bröer S., Free PMC Article | 02/8/2014 |
| the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 and the neutral amino acid transporter B0AT1 | Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1.
Fairweather SJ, Bröer A, O'Mara ML, Bröer S., Free PMC Article | 11/3/2012 |
| Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. | Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse.
Bröer A, Juelich T, Vanslambrouck JM, Tietze N, Solomon PS, Holst J, Bailey CG, Rasko JE, Bröer S., Free PMC Article | 10/1/2011 |
| Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts. | Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response.
Einecke G, Kayser D, Vanslambrouck JM, Sis B, Reeve J, Mengel M, Famulski KS, Bailey CG, Rasko JE, Halloran PF. | 06/25/2011 |
| Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo. | The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.
Böhmer C, Sopjani M, Klaus F, Lindner R, Laufer J, Jeyaraj S, Lang F, Palmada M. | 09/27/2010 |
| functional association of mutant B(0)AT1 transporters with ACE2 and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder | Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Camargo SM, Singer D, Makrides V, Huggel K, Pos KM, Wagner CA, Kuba K, Danilczyk U, Skovby F, Kleta R, Penninger JM, Verrey F., Free PMC Article | 01/21/2010 |
| The relatively constant [Na(+)] along the renal proximal tubule both drives the uptake of neutral amino acids via B(0)AT1 thermodynamically and ensures that, upon binding, these are translocated efficiently into the cell. | Steady-state kinetic characterization of the mouse B(0)AT1 sodium-dependent neutral amino acid transporter.
Camargo SM, Makrides V, Virkki LV, Forster IC, Verrey F. | 01/21/2010 |
| The mechanism of the mouse (m)B0AT1 (slc6a19) transporter was studied in detail using two electrode voltage-clamp techniques and tracer studies in the Xenopus oocyte expression system. | Characterization of mouse amino acid transporter B0AT1 (slc6a19).
Böhmer C, Bröer A, Munzinger M, Kowalczuk S, Rasko JE, Lang F, Bröer S., Free PMC Article | 01/21/2010 |
| This study shows the luminal brush-border localization of the Na(+)-dependent amino and imino acid transporters B degrees AT1 and XT3s1/SIT1 in kidney and intestine. | Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus.
Romeo E, Dave MH, Bacic D, Ristic Z, Camargo SM, Loffing J, Wagner CA, Verrey F. | 01/21/2010 |
| We isolated the human homolog of B(0)AT1, called SLC6A19, and determined its size and molecular organization. We then identified mutations in SLC6A19 in members of the original family in whom Hartnup disorder was discovered | Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.
Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A. | 01/21/2010 |