| DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons. | DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.
Pensold D, Reichard J, Van Loo KMJ, Ciganok N, Hahn A, Bayer C, Liebmann L, Groß J, Tittelmeier J, Lingner T, Salinas-Riester G, Symmank J, Halfmann C, González-Bermúdez L, Urbach A, Gehrmann J, Costa I, Pieler T, Hübner CA, Vatter H, Kampa B, Becker AJ, Zimmer-Bensch G., Free PMC Article | 12/18/2021 |
| Crosstalk between WIP and Rho family GTPases. | Crosstalk between WIP and Rho family GTPases.
Antón IM, Gómez-Oro C, Rivas S, Wandosell F., Free PMC Article | 07/17/2021 |
| PD-L1 promotes tumor growth and progression by activating WIP and beta-catenin signaling pathways and predicts poor prognosis in lung cancer. | PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.
Yu W, Hua Y, Qiu H, Hao J, Zou K, Li Z, Hu S, Guo P, Chen M, Sui S, Xiong Y, Li F, Lu J, Guo W, Luo G, Deng W., Free PMC Article | 03/27/2021 |
| The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View. | The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View.
Sokolik CG, Qassem N, Chill JH., Free PMC Article | 02/13/2021 |
| Authors identified WIPF1 as an oncoprotein in PDAC and a direct target of miR-141/miR-200c. They also defined the miR-141/200c-WIPF1-YAP/TAZ as a novel signaling pathway that is involved in the regulation of the invasion and metastasis of human PDAC cells. | WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC.
Pan Y, Lu F, Xiong P, Pan M, Zhang Z, Lin X, Pan M, Huang H., Free PMC Article | 03/30/2019 |
| WIP deficiency should be considered as a cause for autosomal-recessive immunodeficiency | Hematopoietic stem cell transplantation corrects WIP deficiency.
Al-Mousa H, Hawwari A, Al-Ghonaium A, Al-Saud B, Al-Dhekri H, Al-Muhsen S, Elshorbagi S, Dasouki M, El-Baik L, Alseraihy A, Ayas M, Arnaout R. | 12/22/2018 |
| WIP residues 454-456 are the major contributor to WASp affinity, and residues 449-451 were found to have the largest effect upon WASp ubiquitylation and, presumably, degradation. | New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.
Halle-Bikovski A, Fried S, Rozentur-Shkop E, Biber G, Shaked H, Joseph N, Barda-Saad M, Chill JH. | 05/5/2018 |
| the present study identifies the WIPF1 gene as having novel oncogenic functions and playing an important role in the invasiveness and aggressiveness of thyroid cancer when aberrantly up-regulated by the BRAF V600E/MAPK pathway through its promoter demethylation. | Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness.
Zhang T, Shen X, Liu R, Zhu G, Bishop J, Xing M., Free PMC Article | 03/10/2018 |
| WIP controls tumor growth by boosting signals that stabilize the YAP/TAZ complex via a mechanism mediated by the endocytic/endosomal system. | WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth.
Gargini R, Escoll M, García E, García-Escudero R, Wandosell F, Antón IM. | 11/25/2017 |
| Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics. | Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.
Siar CH, Rahman ZA, Tsujigiwa H, Mohamed Om Alblazi K, Nagatsuka H, Ng KH. | 09/23/2017 |
| establish a new cancer stem cell signalling pathway downstream of mtp53 in which AKT2 regulates WIP and controls YAP/TAZ stability. | Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ.
Escoll M, Gargini R, Cuadrado A, Anton IM, Wandosell F. | 09/16/2017 |
| Knocking down WIP expression in A549 cells significantly reduced RhoA levels and WIP was found to interact with RhoA suggesting that WIP might be executing its function by regulating RhoA. | WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels.
Salvi A, Thanabalu T. | 06/10/2017 |
| Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. | WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion.
García E, Ragazzini C, Yu X, Cuesta-García E, Bernardino de la Serna J, Zech T, Sarrió D, Machesky LM, Antón IM., Free PMC Article | 02/4/2017 |
| conclude that tyrosine phosphorylation of WIP is a crucial regulator of WASP stability and function as an actin-nucleation-promoting factor | Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.
Vijayakumar V, Monypenny J, Chen XJ, Machesky LM, Lilla S, Thrasher AJ, Antón IM, Calle Y, Jones GE., Free PMC Article | 03/5/2016 |
| WIP was shown to interact with various binding partners, including the signaling proteins Nck, CrkL and cortactin. | WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions.
Noy E, Fried S, Matalon O, Barda-Saad M., Free PMC Article | 08/15/2015 |
| Data indicate the WASp-interacting protein (WIP)-Wiskott-Aldrich syndrome protein (WASp) interaction in the regulation of actin-dependent processes. | Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex.
Fried S, Reicher B, Pauker MH, Eliyahu S, Matalon O, Noy E, Chill J, Barda-Saad M. | 02/21/2015 |
| These findings reveal WIP as a previously unreported regulator of neuronal maturation and synaptic activity | WIP is a negative regulator of neuronal maturation and synaptic activity.
Franco A, Knafo S, Banon-Rodriguez I, Merino-Serrais P, Fernaud-Espinosa I, Nieto M, Garrido JJ, Esteban JA, Wandosell F, Anton IM. | 08/11/2012 |
| These findings indicate that WIP deficiency should be suspected in patients with features of WAS in whom WAS sequence and mRNA levels are normal. | A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP.
Lanzi G, Moratto D, Vairo D, Masneri S, Delmonte O, Paganini T, Parolini S, Tabellini G, Mazza C, Savoldi G, Montin D, Martino S, Tovo P, Pessach IM, Massaad MJ, Ramesh N, Porta F, Plebani A, Notarangelo LD, Geha RS, Giliani S., Free PMC Article | 04/14/2012 |
| The results suggest that some of the mutations in the WH1 domain cause the Wiskott-Aldrich syndrome syndrome in humans by perturbing the WASP-WIP complex formation. | Characterization of Wiskott-Aldrich syndrome (WAS) mutants using Saccharomyces cerevisiae.
Rajmohan R, Raodah A, Wong MH, Thanabalu T. | 02/22/2010 |
| Groups of colorectal cancer, breast cancer, and glioma patients with low expression of the WIPF1 co-expression module generally had a favorable prognosis. | An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types.
Staub E, Groene J, Heinze M, Mennerich D, Roepcke S, Klaman I, Hinzmann B, Castanos-Velez E, Pilarsky C, Mann B, Brümmendorf T, Weber B, Buhr HJ, Rosenthal A., Free PMC Article | 01/21/2010 |
| formin-binding protein 17 (FBP17) recruits WASP, WASP-interacting protein (WIP), and dynamin-2 to the plasma membrane and that this recruitment is necessary for the formation of podosomes and phagocytic cups. | FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.
Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, Terayama Y, Yamaya K, Ohyama C, Nonoyama S, Ochs HD., Free PMC Article | 01/21/2010 |
| WIP is involved in lytic granule transport and is essential for regulation of Natural killer cell cytotoxic function | WIP is essential for lytic granule polarization and NK cell cytotoxicity.
Krzewski K, Chen X, Strominger JL., Free PMC Article | 01/21/2010 |
| that WASP and WASP-interacting protein (WIP) form a complex at the phagocytic cup and that the WASP.WIP complex plays a critical role in the phagocytic cup formation. | Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages.
Tsuboi S, Meerloo J. | 01/21/2010 |
| In this review, in addition to its WASP-independent functions, the role of WIP is to regulate the activity and stability of WASP and shuttle WASP to areas of actin assembly. | WASP-interacting protein (WIP): working in polymerisation and much more.
Antón IM, Jones GE, Wandosell F, Geha R, Ramesh N. | 01/21/2010 |
| the WIP-WASP complex plays an important role in WASP stabilization and NFAT activation | Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory.
Dong X, Patino-Lopez G, Candotti F, Shaw S., Free PMC Article | 01/21/2010 |