| Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis. | Multilevel Regulation of NF-κB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis.
Feng W, Niu N, Lu P, Chen Z, Rao H, Zhang W, Ma C, Liu C, Xu Y, Gao WQ, Xue J, Li L., Free PMC Article | 09/24/2024 |
| NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome. | NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome.
Sobh A, Encinas E, Patel A, Surapaneni G, Bonilla E, Kaestner C, Poullard J, Clerio M, Vasan K, Freeman T, Lv D, Dupéré-Richer D, Riva A, Barwick BG, Zhou D, Boise LH, Mitsiades CS, Kim B, Bennett RL, Chandel NS, Licht JD. | 08/5/2024 |
| ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin. | ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin.
Goto N, Suke K, Yonezawa N, Nishihara H, Handa T, Sato Y, Kujirai T, Kurumizaka H, Yamagata K, Kimura H., | 05/9/2024 |
| Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2. | Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2.
Qin CM, Wei XW, Wu JY, Liu XQ, Lin Y., Free PMC Article | 02/22/2024 |
| Clinical details of individuals with Rauch-Steindl syndrome due to NSD2 truncating variants. | Clinical details of individuals with Rauch-Steindl syndrome due to NSD2 truncating variants.
Nishi E, Yanagi K, Kaname T, Okamoto N., Free PMC Article | 02/20/2024 |
| Histone Methyltransferase NSD2 Activates PKCalpha to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma. | Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma.
Chong PSY, Chooi JY, Lim JSL, Leow ACY, Toh SHM, Azaman I, Koh MY, Teoh PJ, Tan TZ, Chung TH, Chng WJ. | 10/25/2023 |
| The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation. | The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.
Khella MS, Schnee P, Weirich S, Bui T, Bröhm A, Bashtrykov P, Pleiss J, Jeltsch A., Free PMC Article | 07/7/2023 |
| WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression. | WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression.
Yan J, Zhang MY, Lin J, Li KX, Zhao ZM, Gao YM, Deng XL, Wang CS, Wang HS., Free PMC Article | 05/17/2023 |
| NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization. | NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization.
Narang S, Evensen NA, Saliba J, Pierro J, Loh ML, Brown PA, Kolekar P, Mulder H, Shao Y, Easton J, Ma X, Tsirigos A, Carroll WL., Free PMC Article | 04/6/2023 |
| The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM. | The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM.
Stong N, Ortiz-Estévez M, Towfic F, Samur M, Agarwal A, Corre J, Flynt E, Munshi N, Avet-Loiseau H, Thakurta A., Free PMC Article | 04/4/2023 |
| The constitutional gain-of-function variant p.Glu1099Lys in NSD2 is associated with a novel syndrome. | The constitutional gain-of-function variant p.Glu1099Lys in NSD2 is associated with a novel syndrome.
Popp B, Brugger M, Poschmann S, Bartolomaeus T, Radtke M, Hentschel J, Di Donato N, Rump A, Gburek-Augustat J, Graf E, Wagner M, Sorge I, Lemke JR, Meitinger T, Abou Jamra R, Strehlow V, Brunet T. | 01/21/2023 |
| H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis. | H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis.
Li Z, Zhang X, Xie S, Liu X, Fei C, Huang X, Tang Y, Zhou LQ., Free PMC Article | 12/24/2022 |
| The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors. | The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.
Topchu I, Pangeni RP, Bychkov I, Miller SA, Izumchenko E, Yu J, Golemis E, Karanicolas J, Boumber Y., Free PMC Article | 05/14/2022 |
| NSD2 activates the E2F transcription factor 1/Y-box binding protein 2 axis to promote the malignant development of oral squamous cell carcinoma. | NSD2 activates the E2F transcription factor 1/Y-box binding protein 2 axis to promote the malignant development of oral squamous cell carcinoma.
Zhang L, Hu G. | 05/7/2022 |
| Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-gamma-stimulated antitumor immunity. | Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
Ren J, Li N, Pei S, Lian Y, Li L, Peng Y, Liu Q, Guo J, Wang X, Han Y, Zhang G, Wang H, Li Y, Jiang J, Li Q, Tan M, Peng J, Hu G, Xiao Y, Li X, Lin M, Qin J., Free PMC Article | 04/30/2022 |
| Posttranslational modification of Aurora A-NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma. | Posttranslational modification of Aurora A-NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma.
Jiang H, Wang Y, Wang J, Wang Y, Wang S, He E, Guo J, Xie Y, Wang J, Li X, Peng Z, Wang M, Hou J, Liu Z., Free PMC Article | 04/23/2022 |
| METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy. | METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy.
Tang W, Zhao Y, Zhang H, Peng Y, Rui Z., Free PMC Article | 04/9/2022 |
| Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy. | Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy.
Peng X, Peng Q, Zhong L., Free PMC Article | 03/12/2022 |
| A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. | A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Dilworth D, Hanley RP, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, Marunde MR, Ackloo S, Carvalho Machado RA, Khalili Yazdi A, Owens DDG, Vu V, Nie DY, Alqazzaz M, Marcon E, Li F, Chau I, Bolotokova A, Qin S, Lei M, Liu Y, Szewczyk MM, Dong A, Kazemzadeh S, Abramyan T, Popova IK, Hall NW, Meiners MJ, Cheek MA, Gibson E, Kireev D, Greenblatt JF, Keogh MC, Min J, Brown PJ, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, James LI, Schapira M., Free PMC Article | 02/26/2022 |
| Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. | Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.
Guan S, Li L, Chen WS, Jiang WY, Ding Y, Zhao LL, Shi YF, Wang J, Gui Q, Xu CC, Cheng Y, Zhang W., Free PMC Article | 02/26/2022 |
| Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer. | Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer.
Zhao LH, Li Q, Huang ZJ, Sun MX, Lu JJ, Zhang XH, Li G, Wu F., Free PMC Article | 02/19/2022 |
| NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. | NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis.
Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko Ł, Li W, Mazur PK, Gozani O., Free PMC Article | 01/8/2022 |
| Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis. | Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis.
Li S, Shi Z, Fu S, Li Q, Li B, Sang L, Wu D., Free PMC Article | 01/1/2022 |
| CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression. | CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression.
Lyu P, Zhai Z, Hao Z, Zhang H, He J. | 01/1/2022 |
| WHSC1/NSD2 regulates immune infiltration in prostate cancer. | WHSC1/NSD2 regulates immune infiltration in prostate cancer.
Want MY, Tsuji T, Singh PK, Thorne JL, Matsuzaki J, Karasik E, Gillard B, Cortes Gomez E, Koya RC, Lugade A, Odunsi K, Battaglia S., Free PMC Article | 12/18/2021 |