| A Significant Increasing Risk Association between Cigarette Smoking and XPA and XPC Genes Polymorphisms. | A Significant Increasing Risk Association between Cigarette Smoking and XPA and XPC Genes Polymorphisms.
Almushawwah S, Almutairi MH, Alamri AM, Semlali A., Free PMC Article | 09/8/2023 |
| Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. | Lesion recognition by XPC, TFIIH and XPA in DNA excision repair.
Kim J, Li CL, Chen X, Cui Y, Golebiowski FM, Wang H, Hanaoka F, Sugasawa K, Yang W., Free PMC Article | 05/17/2023 |
| A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair. | A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair.
van den Heuvel D, Kim M, Wondergem AP, van der Meer PJ, Witkamp M, Lambregtse F, Kim HS, Kan F, Apelt K, Kragten A, González-Prieto R, Vertegaal ACO, Yeo JE, Kim BG, van Doorn R, Schärer OD, Luijsterburg MS., Free PMC Article | 03/16/2023 |
| Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells. | Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells.
Banicka V, Martens MC, Panzer R, Schrama D, Emmert S, Boeckmann L, Thiem A., Free PMC Article | 10/22/2022 |
| XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair. | XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair.
Dai W, Wu A, Li Y, Yu G, Yan X., Free PMC Article | 05/14/2022 |
| Nucleotide Excision Repair Pathway Activity Is Inhibited by Airborne Particulate Matter (PM10) through XPA Deregulation in Lung Epithelial Cells. | Nucleotide Excision Repair Pathway Activity Is Inhibited by Airborne Particulate Matter (PM(10)) through XPA Deregulation in Lung Epithelial Cells.
Quezada-Maldonado EM, Chirino YI, Gonsebatt ME, Morales-Bárcenas R, Sánchez-Pérez Y, García-Cuellar CM., Free PMC Article | 03/26/2022 |
| Probing Protein-DNA Conformational Dynamics in DNA Damage Recognition: Xeroderma Pigmentosum Group A Stabilizes the Damaged DNA-RPA14 Complex by Controlling Conformational Fluctuation Dynamics. | Probing Protein-DNA Conformational Dynamics in DNA Damage Recognition: Xeroderma Pigmentosum Group A Stabilizes the Damaged DNA-RPA14 Complex by Controlling Conformational Fluctuation Dynamics.
Jaiswal S, Han X, Lu HP. | 02/26/2022 |
| XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells. | XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells.
Khan S, Cvammen W, Anabtawi N, Choi JH, Kemp MG., Free PMC Article | 01/29/2022 |
| Xeroderma pigmentosum A homolog from Hydra partially complements DNA repair defect in human XPA-deficient cells. | Xeroderma pigmentosum A homolog from Hydra partially complements DNA repair defect in human XPA-deficient cells.
Galande AA, Saijo M, Ghaskadbi SS, Ghaskadbi S. | 12/4/2021 |
| Regulation of XPA could play a role in inhibition of radiation-induced bystander effects in QU-DB cells at high doses. | Regulation of XPA could play a role in inhibition of radiation-induced bystander effects in QU-DB cells at high doses.
Toossi MTB, Azimian H, Soleymanifard S, Vosoughi H, Dolat E, Rezaei AR, Khademi S. | 09/4/2021 |
| XPA deficiency affects the ubiquitin-proteasome system function. | XPA deficiency affects the ubiquitin-proteasome system function.
de Sousa Leal AM, de Azevedo Medeiros LB, Muñoz-Cadavid CO, de Paula Oliveira R, de Souza Timóteo AR, de Oliveira AHS, Luis Fonseca Faustino A, da Silva VL, de Souza SJ, Braz Petta Lajus T, de Melo Campos JTA, Agnez-Lima LF. | 04/3/2021 |
| XPA: DNA Repair Protein of Significant Clinical Importance. | XPA: DNA Repair Protein of Significant Clinical Importance.
Borszéková Pulzová L, Ward TA, Chovanec M., Free PMC Article | 01/9/2021 |
| Alcohol Effects on Colon Epithelium are Time-Dependent. | Alcohol Effects on Colon Epithelium are Time-Dependent.
Bishehsari F, Zhang L, Voigt RM, Maltby N, Semsarieh B, Zorub E, Shaikh M, Wilber S, Armstrong AR, Mirbagheri SS, Preite NZ, Song P, Stornetta A, Balbo S, Forsyth CB, Keshavarzian A., Free PMC Article | 10/10/2020 |
| This study reports 2.06A-resolution structure of the redefined DNA-binding domain of XPA. C-terminal 21-residues extension of XPA is folded as a long alpha-helix. | Structural characterization of the redefined DNA-binding domain of human XPA.
Lian FM, Yang X, Yang W, Jiang YL, Qian C. | 06/20/2020 |
| XPA expression is an additional independent prognostic biomarker for stratifying germ cell tumours patients, allowing for improvements in decision-making on treatment for those at high risk of refractoriness or relapse. | Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours.
Cierna Z, Miskovska V, Roska J, Jurkovicova D, Pulzova LB, Sestakova Z, Hurbanova L, Machalekova K, Chovanec M, Rejlekova K, Svetlovska D, Kalavska K, Kajo K, Babal P, Mardiak J, Ward TA, Mego M, Chovanec M., Free PMC Article | 06/20/2020 |
| Our results confirm its dependence on XPA in NER and furthermore show that its engagement in ICLR is dependent on FANCD2. Interestingly, we find that two ICLR-defective XPF mutants (R689S and S786F) are less well recruited to ICLs. These studies highlight the differential mechanisms that regulate ERCC1-XPF activity in DNA repair | ERCC1-XPF targeting to psoralen-DNA crosslinks depends on XPA and FANCD2.
Sabatella M, Pines A, Slyskova J, Vermeulen W, Lans H., Free PMC Article | 05/30/2020 |
| Combining NMR and X-ray scattering data with comprehensive docking and refinement revealed how XPA DBD and RPA70AB orient on model NER DNA substrates. The structural model enabled design of XPA mutations that inhibit the interaction with RPA70AB | A key interaction with RPA orients XPA in NER complexes.
Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ., Free PMC Article | 03/21/2020 |
| The results indicate that core nucleotide excision repair (NER) components XPA and XPF are equally required and that both global genome (GG-NER) and transcription coupled (TC-NER) subpathways contribute to the repair. | Nucleotide excision repair of abasic DNA lesions.
Kitsera N, Rodriguez-Alvarez M, Emmert S, Carell T, Khobta A., Free PMC Article | 12/7/2019 |
| The redefined DNA-binding domain of human XPA protein has been reported. | The redefined DNA-binding domain of human xeroderma pigmentosum complementation group A: production, crystallization and structure solution.
Lian FM, Yang X, Yang W, Jiang YL, Qian C., Free PMC Article | 04/13/2019 |
| XPA A23G gene polymorphism may be one low-penetrant risk factor for esophageal cancer in Chinese individuals. [meta-analysis] | Meta-analysis on the association between xeroderma pigmentosum Group A A23G polymorphism and esophageal cancer in a Chinese population.
Xu JL, Bai J, Jiao JF, Ding L, Lei L, Bai XP, Cheng YF. | 03/9/2019 |
| Reduced protein expression levels of DNA excision repair protein ERCC-3 (ERCC3) and XPA nucleotide excision repair protein (XPA) were associated with an increased risk of squamous cell carcinoma of head and neck (SCCHN). | Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.
Han P, Liu H, Shi Q, Liu Z, Troy JD, Lee WT, Zevallos JP, Li G, Sturgis EM, Wei Q., Free PMC Article | 03/2/2019 |
| XPA rs1800975 played a role in the development of early-onset preeclampsia in Chinese Han Women | The relationship between DNA repair genes (XPA, XPF, XPG) polymorphism and the risk of preeclampsia in Chinese Han Women.
Wang H, Liu J, Zhang R, Liu Y, Ren X, Gao K, Zhao C, Liu S. | 02/2/2019 |
| It provides evidence for an H4K20me2-dependent mechanism of XPA recruitment during lesion recognition in the global-genomic branch of NER. | DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites.
Chitale S, Richly H., Free PMC Article | 12/22/2018 |
| This study suggested that the XPA gene rs1800975 Polymorphism was associated with lung cancer susceptibility. By performing multiple separate pairwise comparisons, carriers with AG genotype under the codominant genetic model (AG vs. AA) might play actually the leading role in associating with lung cancer susceptibility in overall and in Asians. | Association between XPA gene rs1800975 polymorphism and susceptibility to lung cancer: a meta-analysis.
Liu X, Lin Q, Fu C, Liu C, Zhu F, Liu Z, Li S, Jiang L. | 09/15/2018 |
| We have suggested that the nuclear localization signal on XPA is masked, perhaps in a complex with a cytosolic XPA sequestration protein, and that this complex is disrupted by methanol fixation in non-stressed cells and as part of the DNA damage response following UV irradiation | XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage in a cell cycle dependent manner.
Musich PR, Li Z, Shell SM, Zou Y. | 09/1/2018 |