| Genetic evidence for predisposition to acute leukemias due to a missense mutation (p.Ser518Arg) in ZAP70 kinase: a case-control study. | Genetic evidence for predisposition to acute leukemias due to a missense mutation (p.Ser518Arg) in ZAP70 kinase: a case-control study.
Khashei Varnamkhasti K, Khashei Varnamkhasti S, Shahrouzian A, Rahimzadeh M, Naeimi L, Naeimi B, Naeimi S., Free PMC Article | 09/16/2024 |
| Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation? | Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?
Ghergus D, Martin M, Knapp AM, Delmotte F, Joublin-Delavat A, Jung S, Schickel JN, Mendel I, Dupuis A, Drénou B, Ghesquières H, Salles G, Baseggio L, Herbrecht R, Korganow AS, Vallat L, Soulas-Sprauel P, Meffre E, Martin T. | 12/27/2023 |
| Decoding the deactivation mechanism of R192W mutation of ZAP-70 using molecular dynamics simulations and binding free energy calculations. | Decoding the deactivation mechanism of R192W mutation of ZAP-70 using molecular dynamics simulations and binding free energy calculations.
Zhang X, Liang W, Zheng G, Li B. | 11/28/2023 |
| Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain. | Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain.
Mongellaz C, Vicente R, Noroski LM, Noraz N, Courgnaud V, Chinen J, Faria E, Zimmermann VS, Taylor N., Free PMC Article | 06/21/2023 |
| Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells. | Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells.
Anto NP, Arya AK, Muraleedharan A, Shaik J, Nath PR, Livneh E, Sun Z, Braiman A, Isakov N., Free PMC Article | 12/17/2022 |
| Identification of LAT/ZAP70 characterized immune subtypes of prostate cancer. | Identification of LAT/ZAP70 characterized immune subtypes of prostate cancer.
Yu J, Gao W, Gao S, Wen S, Zhao Y, Shang Z, Wang Y, Niu Y. | 11/5/2022 |
| A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling. | A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Hartig R, Minguet S, Schraven B, Simeoni L., Free PMC Article | 10/8/2022 |
| AQP9 and ZAP70 as immune-related prognostic biomarkers suppress proliferation, migration and invasion of laryngeal cancer cells. | AQP9 and ZAP70 as immune-related prognostic biomarkers suppress proliferation, migration and invasion of laryngeal cancer cells.
Ren L, Li P, Li Z, Chen Q., Free PMC Article | 05/14/2022 |
| SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies. | SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Leveille E, Chan LN, Mirza AS, Kume K, Müschen M. | 05/7/2022 |
| Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor. | Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor.
Goyette J, Depoil D, Yang Z, Isaacson SA, Allard J, van der Merwe PA, Gaus K, Dustin ML, Dushek O., Free PMC Article | 03/26/2022 |
| The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling. | The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling.
Fazil MHUT, Chirumamilla CS, Perez-Novo C, Wong BHS, Kumar S, Sze SK, Vanden Berghe W, Verma NK., Free PMC Article | 02/19/2022 |
| T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival. | T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival.
de Mel S, Mustafa N, Selvarajan V, Azaman MI, Jaynes PW, Venguidessane S, Phuong HM, Alnaseri ZT, Phyu T, Girard LP, Chng WJ, Wardyn J, Li Y, An O, Yang H, Ng SB, Jeyasekharan AD., Free PMC Article | 02/12/2022 |
| Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. | Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Hobbs HT, Shah NH, Badroos JM, Gee CL, Marqusee S, Kuriyan J., Free PMC Article | 02/12/2022 |
| Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling. | Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling.
Kaman K, Abrams M, Dobbs K, Notarangelo LD, Delmonte OM, Palterer B, Pai SY, Johnston A., Free PMC Article | 01/22/2022 |
| ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. | ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia.
Chen J, Sathiaseelan V, Moore A, Tan S, Chilamakuri CSR, Roamio Franklin VN, Shahsavari A, Jakwerth CA, Hake SB, Warren AJ, Mohorianu I, D'Santos C, Ringshausen I. | 12/4/2021 |
| A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands. | A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.
Shen L, Matloubian M, Kadlecek TA, Weiss A., Free PMC Article | 11/27/2021 |
| TREM-2 promotes Th1 responses by interacting with the CD3zeta-ZAP70 complex following Mycobacterium tuberculosis infection. | TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection.
Wu Y, Wu M, Ming S, Zhan X, Hu S, Li X, Yin H, Cao C, Liu J, Li J, Wu Z, Zhou J, Liu L, Gong S, He D, Huang X., Free PMC Article | 11/13/2021 |
| Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse. | Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse.
Kim B, Kim HY, Lee WW., Free PMC Article | 10/30/2021 |
| T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. | T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.
Tewari R, Shayahati B, Fan Y, Akimzhanov AM., Free PMC Article | 08/28/2021 |
| Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer. | Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Sadras T, Martin M, Kume K, Robinson ME, Saravanakumar S, Lenz G, Chen Z, Song JY, Siddiqi T, Oksa L, Knapp AM, Cutler J, Cosgun KN, Klemm L, Ecker V, Winchester J, Ghergus D, Soulas-Sprauel P, Kiefer F, Heisterkamp N, Pandey A, Ngo V, Wang L, Jumaa H, Buchner M, Ruland J, Chan WC, Meffre E, Martin T, Müschen M., Free PMC Article | 06/19/2021 |
| Time-dependent decline of T-cell receptor excision circle levels in ZAP-70 deficiency. | Time-dependent decline of T-cell receptor excision circle levels in ZAP-70 deficiency.
Suresh S, Dadi H, Reid B, Vong L, Bulman DE, Roifman CM. | 06/12/2021 |
| Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review. | Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review.
Sharifinejad N, Jamee M, Zaki-Dizaji M, Lo B, Shaghaghi M, Mohammadi H, Jadidi-Niaragh F, Shaghaghi S, Yazdani R, Abolhassani H, Aghamohammadi A, Azizi G., Free PMC Article | 05/22/2021 |
| A micropatterning platform for quantifying interaction kinetics between the T cell receptor and an intracellular binding protein. | A micropatterning platform for quantifying interaction kinetics between the T cell receptor and an intracellular binding protein.
Motsch V, Brameshuber M, Baumgart F, Schütz GJ, Sevcsik E., Free PMC Article | 09/19/2020 |
| basal ZAP70 activation in resting T cell lines reduced the threshold ("primed") TCR-stimulated activation of the classical p38 pathway | Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Jun JE, Kulhanek KR, Chen H, Chakraborty A, Roose JP., Free PMC Article | 08/1/2020 |
| These findings demonstrate that PKCtheta; plays an important role in a positive feedback regulatory loop that modulates TCR-proximal signaling and, moreover, provide a mechanistic explanation for earlier reports that documented an important role for PKCtheta; in T cell Ca(2+) signaling. This PKCtheta;-Zap70 interaction could potentially serve as a promising and highly selective immunosuppressive drug target in autoimmu... | Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling.
Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd, Li Y, Lillemeier BF, Altman A., Free PMC Article | 07/4/2020 |