| ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream from transcription start sites at the majority of CpG island promoters. | ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream from transcription start sites at the majority of CpG island promoters.
Rhie SK, Yao L, Luo Z, Witt H, Schreiner S, Guo Y, Perez AA, Farnham PJ., Free PMC Article | 07/31/2024 |
| Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt. | Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt.
Shepherdson JL, Hutchison K, Don DW, McGillivray G, Choi TI, Allan CA, Amor DJ, Banka S, Basel DG, Buch LD, Carere DA, Carroll R, Clayton-Smith J, Crawford A, Dunø M, Faivre L, Gilfillan CP, Gold NB, Gripp KW, Hobson E, Holtz AM, Innes AM, Isidor B, Jackson A, Katsonis P, Amel Riazat Kesh L, Genomics England Research Consortium, Küry S, Lecoquierre F, Lockhart P, Maraval J, Matsumoto N, McCarrier J, McCarthy J, Miyake N, Moey LH, Németh AH, Østergaard E, Patel R, Pope K, Posey JE, Schnur RE, Shaw M, Stolerman E, Taylor JP, Wadman E, Wakeling E, White SM, Wong LC, Lupski JR, Lichtarge O, Corbett MA, Gecz J, Nicolet CM, Farnham PJ, Kim CH, Shinawi M., Free PMC Article | 03/11/2024 |
| Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis. | Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
Zhou Y, Ma G, Peng S, Tuo M, Li Y, Qin X, Yu Q, Kuang S, Cheng H, Li J., Free PMC Article | 01/29/2022 |
| Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway. | Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway.
Yang D, Ma X, Xu J, Jia K, Liu X, Zhang P., Free PMC Article | 01/1/2022 |
| Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters. | Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.
Ni W, Perez AA, Schreiner S, Nicolet CM, Farnham PJ., Free PMC Article | 09/12/2020 |
| Our data indicate that CCAT1 promotes triple-negative breast cancer progression by targeting the miR-218/ZFX axis | CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.
Han C, Li X, Fan Q, Liu G, Yin J., Free PMC Article | 08/13/2020 |
| LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR-495-3p in gastric cancer | LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR-495-3p in gastric cancer.
Cui N, Liu J, Xia H, Xu D. | 06/27/2020 |
| Homoharringtonine may enhance the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX. | Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX.
Wu J, Wei B, Shi Y, Lu X, Ding Y, Wang C, Li Y., Free PMC Article | 02/8/2020 |
| AR-V7 has both ARE/FOXA1 canonical and ZFX-directed non-canonical regulatory functions in the evolution of anti-androgen therapeutic resistance. | ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.
Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, Wang GG., Free PMC Article | 04/20/2019 |
| ZFX-spliced transcripts could be considered as novel tumor markers with a probable value in diagnosis, prognosis, and therapy of breast cancer. | Differential Expression Profile of ZFX Variants Discriminates Breast Cancer Subtypes.
Pourkeramati F, Asadi MH, Shakeri S, Farsinejad A., Free PMC Article | 03/2/2019 |
| MiR-493 functioned as tumor suppressor in HCC cells by regulating ZFX expression. Thus, miR-493 may provide potential value for HCC treatment. | MicroRNA-493 suppresses cell proliferation and invasion by targeting ZFX in human hepatocellular carcinoma.
Ding W, Tan H, Li X, Zhang Y, Fang F, Tian Y, Li J, Pan X. | 10/20/2018 |
| The depletion of ZFX using lentiviral shRNAs significantly inhibited cell proliferation by inducing cell cycle arrest in G0/G1 phase and resulted in increased cell apoptosis and invasive repression. | ZFX Promotes Proliferation and Metastasis of Pancreatic Cancer Cells via the MAPK Pathway.
Song X, Zhu M, Zhang F, Zhang F, Zhang Y, Hu Y, Jiang L, Hao Y, Chen S, Zhu Q, Huang W, Lu J, Gu J, Gong W, Li M, Liu Y. | 09/8/2018 |
| The research findings indicate that Zinc finger protein X-linked (ZFX) activates and maintains EpCAM(+) liver cancer stem cells by promoting nuclear translocation and transactivation of beta-catenin. Furthermore, combination of ZFX and epithelial cell adhesion molecule (EpCAM) may serve as a significant indicator for prognosis of patients with hepatocellular carcinoma. | Zinc finger protein X-linked promotes expansion of EpCAM(+) cancer stem-like cells in hepatocellular carcinoma.
Wang C, Fu SY, Wang MD, Yu WB, Cui QS, Wang HR, Huang H, Dong W, Zhang WW, Li PP, Lin C, Pan ZY, Yang Y, Wu MC, Zhou WP., Free PMC Article | 02/24/2018 |
| Findings indicate that zinc-finger protein X-linked (ZFX) promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC patients. | High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage II/III colorectal cancer patients.
Yan X, Shan Z, Yan L, Zhu Q, Liu L, Xu B, Liu S, Jin Z, Gao Y., Free PMC Article | 12/2/2017 |
| colon cancer-associated transcript-1 knockdown inhibits proliferation and invasion of laryngeal squamous cell cancer cells through enhancing zinc finger protein, X-linked by sponging microRNA-218, elucidating a novel colon cancer-associated transcript-1-microRNA-218-zinc finger protein, X-linked regulatory axis in laryngeal squamous cell cancer and providing a promising therapeutic target for laryngeal cancer | Long non-coding RNA CCAT1/miR-218/ZFX axis modulates the progression of laryngeal squamous cell cancer.
Zhang Y, Hu H. | 07/22/2017 |
| EZH2 and ZFX genes do not seem to have an impact on the onset of most parathyroid tumours, both benign and malignant, though further studies on larger cohorts of different ethnicity are needed. | EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms.
Sanpaolo E, Miroballo M, Corbetta S, Verdelli C, Baorda F, Balsamo T, Graziano P, Fabrizio FP, Cinque L, Scillitani A, Muscarella LA, Guarnieri V. | 07/8/2017 |
| Zinc finger and X-linked factor ZFX transactivates the SET transcript 2 promoter through binding to a site closely located to the transcription start site. | Zinc Finger and X-Linked Factor (ZFX) Binds to Human SET Transcript 2 Promoter and Transactivates SET Expression.
Xu S, Duan P, Li J, Senkowski T, Guo F, Chen H, Romero A, Cui Y, Liu J, Jiang SW., Free PMC Article | 04/8/2017 |
| miR-144 has been demonstrated to act as a tumour suppressor in hepatocellular carcinoma (HCC) cell growth and motility by directly targeting ZFX, which implicates its potential applications in the development of HCC treatment | MicroRNA-144 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by targeting ZFX.
Bao H, Li X, Li H, Xing H, Xu B, Zhang X, Liu Z. | 03/18/2017 |
| demonstrated that ZFX is aberrantly expressed in multiple human leukemic cells and it modulates the growth and drug response of leukemic cells partially via B4GALT1, which suggests that ZFX is a new regulator of leukemic cells and warrants intensive investigations on this 'stemness' regulator in these deadly diseases | ZFX modulates the growth of human leukemic cells via B4GALT1.
Wu J, Xiao L, Zhou H, Liu H, Ge Y, Yang J, Li Y, Wu D, Zhao Y, Zhang X. | 02/4/2017 |
| ZFX is a novel oncogene promoting cell proliferation and inducing imatinib resistance via PI3K/Akt signaling pathway | ZFX Facilitates Cell Proliferation and Imatinib Resistance in Chronic Myeloid Leukemia Cells.
Wu J, Wei B, Wang Q, Ding Y, Deng Z, Lu X, Li Y. | 01/28/2017 |
| Zinc finger protein x-linked contributes to patient prognosis, and regulates cell proliferation and apoptosis in human laryngeal squamous cell carcinoma. | Zinc finger protein x-linked (ZFX) contributes to patient prognosis, cell proliferation and apoptosis in human laryngeal squamous cell carcinoma.
Yang F, Ma H, Feng L, Lian M, Wang R, Fan E, Fang J., Free PMC Article | 11/5/2016 |
| ZFX expression may have a role in poor prognosis of renal cell carcinoma patients | ZFX is a Strong Predictor of Poor Prognosis in Renal Cell Carcinoma.
Li C, Li H, Zhang T, Li J, Ma F, Li M, Sui Z, Chang J., Free PMC Article | 07/16/2016 |
| Nasopharyngeal carcinoma patients with high ZFX expression had lower 5-year overall survival rates, progression-free survival rates, loco-regional relapse-free survival rates and distant metastasis-free survival rates than those with low ZFX expression | High expression of Zinc-finger protein X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal carcinoma.
Li Y, Yan X, Yan L, Shan Z, Liu S, Chen X, Zou J, Zhang W, Jin Z., Free PMC Article | 04/9/2016 |
| Our results provide evidence suggesting that ZFX overexpression is associated with the development of tongue SCC and ZFX knockdown is a potential treatment for tumor suppression | Dysregulation of zinc finger protein, X-linked (ZFX) impairs cell proliferation and induces apoptosis in human oral squamous cell carcinorma.
Ma H, Yang F, Lian M, Wang R, Wang H, Feng L, Shi Q, Fang J., Free PMC Article | 11/21/2015 |
| These data demonstrate that ZFX functions as a critical upstream regulator of c-Myc and plays essential roles in the maintenance of the glioma stem cells phenotype | The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.
Fang X, Huang Z, Zhou W, Wu Q, Sloan AE, Ouyang G, McLendon RE, Yu JS, Rich JN, Bao S., Free PMC Article | 10/10/2015 |