| Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer. | Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.
Chen H, Lee LJ, Vincent KM, Xu Z, Liu J, Zhang G, Nakevska Z, Smith D, Lee CH, Postovit LM, Fu Y. | 10/9/2024 |
| ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency. | ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.
Hossain I, Priam P, Reynoso SC, Sahni S, Zhang XX, Côté L, Doumat J, Chik C, Fu T, Lessard JA, Pastor WA., Free PMC Article | 10/8/2024 |
| ZIC2 accelerates growth and stemness in gastric cancer through the Wnt/beta-catenin pathway. | ZIC2 accelerates growth and stemness in gastric cancer through the Wnt/β-catenin pathway.
Yu Y, Tan C, Ding L, Zhu Z, Zhang G, Long C. | 11/16/2023 |
| FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway. | FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway.
Lv Z, Wang M, Hou H, Tang G, Xu H, Wang X, Li Y, Wang J, Liu M., Free PMC Article | 08/3/2023 |
| ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis. | ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
Liu Q, Yang T, Zhang Y, Hu ZD, Liu YM, Luo YL, Liu SX, Zhang H, Zhong Q., Free PMC Article | 07/25/2023 |
| ZIC2 promotes colorectal cancer growth and metastasis through the TGF-beta signaling pathway. | ZIC2 promotes colorectal cancer growth and metastasis through the TGF-β signaling pathway.
Liu F, Shi Z, Bao W, Zheng J, Chen K, Lin Z, Song HN, Luo X, Dong Q, Jiang L, Wang Y, Chen G, Chen X. | 05/7/2022 |
| The tumor-suppressive role of microRNA-873 in nasopharyngeal carcinoma correlates with downregulation of ZIC2 and inhibition of AKT signaling pathway. | The tumor-suppressive role of microRNA-873 in nasopharyngeal carcinoma correlates with downregulation of ZIC2 and inhibition of AKT signaling pathway.
Lv B, Li F, Liu X, Lin L. | 01/1/2022 |
| Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of beta-catenin. | Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of β-catenin.
Xu Z, Zheng J, Chen Z, Guo J, Li X, Wang X, Qu C, Yuan L, Cheng C, Sun X, Yu J., Free PMC Article | 12/25/2021 |
| ZIC2 upregulates lncRNA SNHG12 expression to promote endometrial cancer cell proliferation and migration by activating the Notch signaling pathway. | ZIC2 upregulates lncRNA SNHG12 expression to promote endometrial cancer cell proliferation and migration by activating the Notch signaling pathway.
Cai P, Li G, Wu M, Zhang B, Bai H., Free PMC Article | 12/18/2021 |
| Correlation of zinc finger protein 2, a prognostic biomarker, with immune infiltrates in liver cancer. | Correlation of zinc finger protein 2, a prognostic biomarker, with immune infiltrates in liver cancer.
Sun L, Lin Y, Wang G, Zhang L, Hu L, Lu Z., Free PMC Article | 12/11/2021 |
| Downregulation of LINC00665 suppresses the progression of lung adenocarcinoma via regulating miR-181c-5p/ZIC2 axis. | Downregulation of LINC00665 suppresses the progression of lung adenocarcinoma via regulating miR-181c-5p/ZIC2 axis.
Wei W, Zhao X, Liu J, Zhang Z., Free PMC Article | 07/31/2021 |
| De Novo PORCN and ZIC2 Mutations in a Highly Consanguineous Family. | De Novo PORCN and ZIC2 Mutations in a Highly Consanguineous Family.
Castilla-Vallmanya L, Gürsoy S, Giray-Bozkaya Ö, Prat-Planas A, Bullich G, Matalonga L, Centeno-Pla M, Rabionet R, Grinberg D, Balcells S, Urreizti R., Free PMC Article | 04/24/2021 |
| ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer. | ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer.
Liu ZH, Chen ML, Zhang Q, Zhang Y, An X, Luo YL, Liu XM, Liu SX, Liu Q, Yang T, Liu YM, Liu BL, Zhou AJ, Li MZ, Liu YJ, Liu ZX, Zhong Q. | 03/13/2021 |
| ZIC2 regulates laterality of cardiovascular system. A subset of holoprosencephaly cases with ZIC2 mutation also exhibit heterotaxy. Mouse mutant shows right isomerism indicating lack of left-sided Nodal signalling in the embryo. Mechanistic studies in vitro indicate that ZIC2 is required for Nodal expression at the embryonic node and binds to the Nodal HBE enhancer in epiblast. | A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.
Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen CM, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S., Free PMC Article | 01/26/2021 |
| MicroRNA-129-5p suppresses nasopharyngeal carcinoma lymphangiogenesis and lymph node metastasis by targeting ZIC2. | MicroRNA-129-5p suppresses nasopharyngeal carcinoma lymphangiogenesis and lymph node metastasis by targeting ZIC2.
Yu D, Han GH, Zhao X, Liu X, Xue K, Wang D, Xu CB. | 12/12/2020 |
| Results identified loss of ZIC2 expression following DNA hypomethylation as a promising prognostic biomarker for prostate cancer. | Random forest-based modelling to detect biomarkers for prostate cancer progression.
Toth R, Schiffmann H, Hube-Magg C, Büscheck F, Höflmayer D, Weidemann S, Lebok P, Fraune C, Minner S, Schlomm T, Sauter G, Plass C, Assenov Y, Simon R, Meiners J, Gerhäuser C., Free PMC Article | 08/1/2020 |
| MiR12715p inhibited the progression of AML by targeting ZIC2. | miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2.
Chen X, Yang S, Zeng J, Chen M., Free PMC Article | 06/1/2019 |
| miR-1284 suppressed the proliferation, migration, and invasion of breast cancer cells via targeting ZIC2. | miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.
Zhang P, Yang F, Luo Q, Yan D, Sun S., Free PMC Article | 02/23/2019 |
| the studies confirm the extent of ZIC2 allelic heterogeneity and that pathogenic variants of ZIC2 are associated with both classic and middle interhemispheric variant (MIHV) HPE which arise from defective ventral and dorsal forebrain patterning, respectively. | ZIC2 in Holoprosencephaly.
Barratt KS, Arkell RM. | 07/14/2018 |
| miR-1271/Zic2/PAK4 axis plays an important role in hepatocellular carcinoma progression. | Zic2 promotes tumor growth and metastasis via PAK4 in hepatocellular carcinoma.
Lu SX, Zhang CZ, Luo RZ, Wang CH, Liu LL, Fu J, Zhang L, Wang H, Xie D, Yun JP. | 09/30/2017 |
| Together SMAD3 and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE | Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.
Houtmeyers R, Tchouate Gainkam O, Glanville-Jones HA, Van den Bosch B, Chappell A, Barratt KS, Souopgui J, Tejpar S, Arkell RM. | 07/22/2017 |
| Data show that Zinc finger protein ZIC 2 (ZIC2) is indispensable in the regulation of pancreatic ductal adenocarcinoma (PDAC) cell apoptosis. | Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2.
Inaguma S, Ito H, Riku M, Ikeda H, Kasai K., Free PMC Article | 08/6/2016 |
| ZIC2 acts upstream of OCT4 and recruits the nuclear remodeling factor complex to the OCT4 promoter, initiating OCT4 activation. ZIC2 levels positively correlated to the clinicopathological stages of HCC patients. | ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells.
Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z., Free PMC Article | 01/16/2016 |
| Mutational screening for HPE genes revealed the occurrence of a frameshift mutation in the ZIC2 gene. | Rare nasal cleft in a patient with holoprosencephaly due to a mutation in the ZIC2 gene.
Savastano CP, Bernardi P, Seuánez HN, Moreira MÂ, Orioli IM. | 12/20/2014 |
| ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. | Association between ZIC2, RASGRF1, and SHISA6 genes and high myopia in Japanese subjects.
Oishi M, Yamashiro K, Miyake M, Akagi-Kurashige Y, Kumagai K, Nakata I, Nakanishi H, Yoshikawa M, Oishi A, Gotoh N, Tsujikawa A, Nagahama Study Group, Yamada R, Matsuda F, Yoshimura N. | 01/11/2014 |