| [1]H, [15]N and[13]C resonance assignments of S2A mutant of human carbonic anhydrase II. | (1)H, (15)N and(13)C resonance assignments of S2A mutant of human carbonic anhydrase II.
Neelam, Singh H. | 05/13/2024 |
| XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures. | XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures.
Hull JA, Lee C, Kim JK, Lim SW, Park J, Park S, Lee SJ, Park G, Eom I, Kim M, Hyun H, Combs JE, Andring JT, Lomelino C, Kim CU, McKenna R., | 03/11/2024 |
| Unlocking the Potential of the CA2, CA7, and ITM2C Gene Signatures for the Early Detection of Colorectal Cancer: A Comprehensive Analysis of RNA-Seq Data by Utilizing Machine Learning Algorithms. | Unlocking the Potential of the CA2, CA7, and ITM2C Gene Signatures for the Early Detection of Colorectal Cancer: A Comprehensive Analysis of RNA-Seq Data by Utilizing Machine Learning Algorithms.
Maurya NS, Kushwaha S, Vetukuri RR, Mani A., Free PMC Article | 11/1/2023 |
| Carbonic anhydrase II deficiency. | Carbonic anhydrase II deficiency.
Whyte MP. | 02/28/2023 |
| Carbon Dioxide Sensing by Immune Cells Occurs through Carbonic Anhydrase 2-Dependent Changes in Intracellular pH. | Carbon Dioxide Sensing by Immune Cells Occurs through Carbonic Anhydrase 2-Dependent Changes in Intracellular pH.
Strowitzki MJ, Nelson R, Garcia MP, Tuffs C, Bleul MB, Fitzsimons S, Navas J, Uzieliene I, Ritter AS, Phelan D, Kierans SJ, Blanco A, Bernotiene E, Belton O, Schneider M, Cummins EP, Taylor CT. | 05/28/2022 |
| Carbonic anhydrase 2 and 3 as risk biomarkers for dilated cardiomyopathy associated heart failure. | Carbonic anhydrase 2 and 3 as risk biomarkers for dilated cardiomyopathy associated heart failure.
Su H, Hu K, Liu Z, Chen K, Xu J. | 01/22/2022 |
| Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma. | Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma.
Nortunen M, Parkkila S, Saarnio J, Huhta H, Karttunen TJ., Free PMC Article | 12/11/2021 |
| A novel homozygous nonsense mutation in the CA2 gene (c.368G>A, p.W123X) linked to carbonic anhydrase II deficiency syndrome in a Chinese family. | A novel homozygous nonsense mutation in the CA2 gene (c.368G>A, p.W123X) linked to carbonic anhydrase II deficiency syndrome in a Chinese family.
Yang Y, Tang N, Zhu Y, Zhang L, Cao X, Liu L, Xia W, Li P, Yang Y. | 11/13/2021 |
| Quantitative Secretome Analysis Reveals Clinical Values of Carbonic Anhydrase II in Hepatocellular Carcinoma. | Quantitative Secretome Analysis Reveals Clinical Values of Carbonic Anhydrase II in Hepatocellular Carcinoma.
Xing X, Yuan H, Liu H, Tan X, Zhao B, Wang Y, Ouyang J, Lin M, Liu X, Huang A., Free PMC Article | 10/30/2021 |
| Molecular modelling and dynamics of CA2 missense mutations causative to carbonic anhydrase 2 deficiency syndrome. | Molecular modelling and dynamics of CA2 missense mutations causative to carbonic anhydrase 2 deficiency syndrome.
Shaik NA, Bokhari HA, Masoodi TA, Shetty PJ, Ajabnoor GMA, Elango R, Banaganapalli B. | 06/26/2021 |
| The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II. | The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II.
Cabaleiro-Lago C, Lundqvist M., Free PMC Article | 03/20/2021 |
| Study of glycation process of human carbonic anhydrase II as well as investigation concerning inhibitory influence of 3-beta-hydroxybutyrate on it. | Study of glycation process of human carbonic anhydrase II as well as investigation concerning inhibitory influence of 3-beta-hydroxybutyrate on it.
Gharib R, Khatibi A, Khodarahmi R, Haidari M, Husseinzadeh S. | 12/12/2020 |
| Effect of disease-linked mutations on the structure, function, stability and aggregation of human carbonic anhydrase II. | Effect of disease-linked mutations on the structure, function, stability and aggregation of human carbonic anhydrase II.
Gupta P, Mahlawat P, Deep S. | 10/3/2020 |
| The CAII knockdown decreased Tumor endothelial cells survival under lactic acidosis and nutrient-replete conditions. The Vascular endothelial growth factor A and vascular endothelial growth factor receptor signaling induced CAII expression innormal endothelial cells. | Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment.
Annan DA, Maishi N, Soga T, Dawood R, Li C, Kikuchi H, Hojo T, Morimoto M, Kitamura T, Alam MT, Minowa K, Shinohara N, Nam JM, Hida Y, Hida K., Free PMC Article | 10/3/2020 |
| The present study suggests that SSTR5AS1 functions as a competing endogenous RNA to regulate CA2 by sponging miR15b5p for the development and prognosis of hepatitis B virus related hepatocellular carcinoma. | SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma.
Xu J, Zhang J, Shan F, Wen J, Wang Y., Free PMC Article | 04/11/2020 |
| Study shows that proton-driven lactate flux is enhanced by the intracellular carbonic anhydrase CAII, which is colocalized with the monocarboxylate transporter MCT1 in MCF-7 breast cancer cells; the results suggest that CAII features a moiety that exclusively mediates proton exchange with the MCT to facilitate transport activity. | A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells.
Noor SI, Jamali S, Ames S, Langer S, Deitmer JW, Becker HM., Free PMC Article | 04/27/2019 |
| the 1.6 A resolution structure of an imidazole-based CA activator in complex with the ubiquitously-expressed human CA II, is reported. | Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function.
Bhatt A, Mondal UK, Supuran CT, Ilies MA, McKenna R. | 02/9/2019 |
| Data report the crystal structure of HCAII. The structural changes seen are consistent with each of the six mutations involved acting largely independently and variously resulting in increased H-bonding, improved packing, and reduced side chain entropy loss on folding to yield the increased stability. These results suggest that for 4 mutations, improvements in backbone conformational energetics is also a contributor. | Structural insights into a thermostable variant of human carbonic anhydrase II.
Kean KM, Porter JJ, Mehl RA, Karplus PA., Free PMC Article | 01/26/2019 |
| CAII, CAIX, and CAXII all have characteristic expression patterns in esophageal adenocarcinoma (EAC), its precursors and normal squamous epithelium. In EAC, CAII downregulation is associated with metastatic disease. CAIX expression is lost towards the more malignant lesions, but in lymph node positive disease, expression seems to be higher. CAXII is only expressed in normal esophageal epithelium. | Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma.
Nortunen M, Huhta H, Helminen O, Parkkila S, Kauppila JH, Karttunen TJ, Saarnio J. | 11/10/2018 |
| present results suggest that CA2 serves as a suppressor of hepatocellular carcinoma metastasis and epithelial-mesenchymal transition and is correlated with favorable overall survival (OS) in hepatocellular carcinoma patients. | Carbonic anhydrase 2 inhibits epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma.
Zhang C, Wang H, Chen Z, Zhuang L, Xu L, Ning Z, Zhu Z, Wang P, Meng Z. | 10/27/2018 |
| The LC/MS analysis of platelet proteome between groups revealed that out of all identified proteins, the only discriminatory protein, affecting aspirin responsiveness, is platelet carbonic anhydrase II (CA II). | Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance.
Jakubowski M, Dębski J, Szahidewicz-Krupska E, Turek-Jakubowska A, Gawryś J, Gawryś K, Skomro R, Derkacz A, Doroszko A., Free PMC Article | 07/21/2018 |
| Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with Acute Myeloid Leukemia (AML) and 30 healthy peers. Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). | Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia.
Menteşe A, Erkut N, Demir S, Özer Yaman S, Sümer A, Doğramacı Ş, Alver A, Sönmez M., Free PMC Article | 07/21/2018 |
| Study presented a detailed analysis of how protein dynamics (specifically the motions of nonreactive residues in the active site and coupled solvent dynamics) influence the rate limiting proton transfer/transport event in HCA II. | Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II.
Taraphder S, Maupin CM, Swanson JM, Voth GA., Free PMC Article | 04/21/2018 |
| These six-membered carbocycles showed nice inhibitory action against AChE and human carbonic anhydrase (hCA) II and I isoforms. The hCA I, II, and AChE were efficiently inhibited by these molecules, with Ki values in the range of 6.70-35.85 nM for hCA I, 18.77-60.84 nM for hCA II, and 0.74-4.60 for AChE, respectively | Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes.
Kocyigit UM, Taslimi P, Gezegen H, Gulçin İ, Ceylan M. | 01/6/2018 |
| These results showed that flavonoids especially malvin and oenin effectively inhibited hCA I and II isoenzymes. | Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes.
Huyut Z, Beydemir Ş, Gülçin İ. | 01/6/2018 |