| ZNF148 inhibits HBV replication by downregulating RXRalpha transcription. | ZNF148 inhibits HBV replication by downregulating RXRα transcription.
Yao X, Xu K, Tao N, Cheng S, Chen H, Zhang D, Yang M, Tan M, Yu H, Chen P, Zhan Z, He S, Li R, Wang C, Wu D, Ren J., Free PMC Article | 06/25/2024 |
| Further delineation of the rare GDACCF (global developmental delay, absent or hypoplastic corpus callosum, dysmorphic facies syndrome): genotype and phenotype of 22 patients with ZNF148 mutations. | Further delineation of the rare GDACCF (global developmental delay, absent or hypoplastic corpus callosum, dysmorphic facies syndrome): genotype and phenotype of 22 patients with ZNF148 mutations.
Szakszon K, Lourenco CM, Callewaert BL, Geneviève D, Rouxel F, Morin D, Denommé-Pichon AS, Vitobello A, Patterson WG, Louie R, Pinto E Vairo F, Klee E, Kaiwar C, Gavrilova RH, Agre KE, Jacquemont S, Khadijé J, Giltay J, van Gassen K, Merő G, Gerkes E, Van Bon BW, Rinne T, Pfundt R, Brunner HG, Caluseriu O, Grasshoff U, Kehrer M, Haack TB, Khelifa MM, Bergmann AK, Cueto-González AM, Martorell AC, Ramachandrappa S, Sawyer LB, Fasel P, Braun D, Isis A, Superti-Furga A, McNiven V, Chitayat D, Ahmed SA, Brennenstuhl H, Schwaibolf EM, Battisti G, Parmentier B, Stevens SJC. | 01/26/2024 |
| Upregulation of the ZNF148/PTX3 axis promotes malignant transformation of dendritic cells in glioma stem-like cells microenvironment. | Upregulation of the ZNF148/PTX3 axis promotes malignant transformation of dendritic cells in glioma stem-like cells microenvironment.
Cheng S, Liu L, Wang D, Li Y, Li S, Yuan J, Huang S, Xu Z, Jia B, Li Z, Dong J., Free PMC Article | 08/9/2023 |
| Loss of ZNF148 enhances insulin secretion in human pancreatic beta cells. | Loss of ZNF148 enhances insulin secretion in human pancreatic β cells.
de Klerk E, Xiao Y, Emfinger CH, Keller MP, Berrios DI, Loconte V, Ekman AA, White KL, Cardone RL, Kibbey RG, Attie AD, Hebrok M., Free PMC Article | 06/9/2023 |
| Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis. | Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis.
Kuang LW, Zhang CC, Li BH, Liu HZ, Wang H, Li GC. | 03/4/2023 |
| Loss of microRNA-147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis. | Loss of microRNA-147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis.
Jiang C, Wu X, Li X, Li M, Zhang W, Tao P, Xu J, Ren X, Mo L, Guo Y, Wang S, Geng M, Zhang F, Tian J, Zhu W, Meng L, Lu S. | 10/9/2021 |
| ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway. | ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway.
Wang N, Li MY, Liu Y, Yu J, Ren J, Zheng Z, Wang S, Yang S, Yang SL, Liu LP, Hu BG, Chong CC, Merchant JL, Lai PB, Chen GG., Free PMC Article | 08/15/2020 |
| Here, we show that succinate accumulation induced by SDHB loss of function increased the expression of zinc finger protein 148 (ZNF148, also named ZBP-89) in astrointestinal stromal tumor (GIST) cells. Meanwhile, ZNF148 is found to be phosphorylated by ERK at Ser306, and this phosphorylation results in ZNF148 binding to Forkhead box M1 (FOXM1) | Upregulation of ZNF148 in SDHB-deficient gastrointestinal stromal tumor potentiates Forkhead box M1-mediated transcription and promotes tumor cell invasion.
Gao X, Ma C, Sun X, Zhao Q, Fang Y, Jiang Y, Shen K, Shen X., Free PMC Article | 04/25/2020 |
| ZNF148(FL) could increase proliferation, invasion, and migration of colorectal cancer cells, while ZNF148(DeltaN) showed opposite effect; the two splicing isoforms of ZNF148 may exert a mutual antagonistic effect to each other on the malignant biological activities. | Regulation between two alternative splicing isoforms ZNF148(FL) and ZNF148(ΔN), and their roles in the apoptosis and invasion of colorectal cancer.
Liu Y, Huang W, Gao X, Kuang F. | 03/23/2019 |
| Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C. | Transcription factor ZNF148 is a negative regulator of human muscle differentiation.
Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T., Free PMC Article | 03/16/2019 |
| ZBP-89 is a potential tumor suppressor in hepatocellular carcinoma (HCC) and it can inhibit the growth of HCC via multiple channels; higher expression of ZBP-89 may predict better survivals and lower recurrence of HCC patients | Targeting ZBP-89 for the treatment of hepatocellular carcinoma.
Wang N, Wang S, Yang SL, Liu LP, Li MY, Lai PBS, Chen GG. | 03/9/2019 |
| Our findings suggested that ZBP-89 and Sp1 overexpression induced Bak expression in a genetic manner. Increased Bak level was associated with poor patient survival, whereas high level of Sp1 is a beneficial factor for patient survival. | ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells.
Kong X, Xu P, Cai WJ, Wang HG, Li BB, Huang GL, He ZW, Chen G, Ye CG., Free PMC Article | 12/22/2018 |
| The results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148 in a manner consistent with elevated TERT in carriers of the C allele. | Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.
Fang J, Jia J, Makowski M, Xu M, Wang Z, Zhang T, Hoskins JW, Choi J, Han Y, Zhang M, Thomas J, Kovacs M, Collins I, Dzyadyk M, Thompson A, O'Neill M, Das S, Lan Q, Koster R, PanScan Consortium, TRICL Consortium, GenoMEL Consortium, Stolzenberg-Solomon RS, Kraft P, Wolpin BM, Jansen PWTC, Olson S, McGlynn KA, Kanetsky PA, Chatterjee N, Barrett JH, Dunning AM, Taylor JC, Newton-Bishop JA, Bishop DT, Andresson T, Petersen GM, Amos CI, Iles MM, Nathanson KL, Landi MT, Vermeulen M, Brown KM, Amundadottir LT., Free PMC Article | 11/17/2018 |
| ZNF148 as a gene involved in a newly described intellectual disability syndrome with a recurrent phenotype and postulate that the ZNF148 is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum. | Truncating de novo mutations in the Krüppel-type zinc-finger gene ZNF148 in patients with corpus callosum defects, developmental delay, short stature, and dysmorphisms.
Stevens SJ, van Essen AJ, van Ravenswaaij CM, Elias AF, Haven JA, Lelieveld SH, Pfundt R, Nillesen WM, Yntema HG, van Roozendaal K, Stegmann AP, Gilissen C, Brunner HG., Free PMC Article | 03/18/2017 |
| A larger role ZBP-89 plays in gene regulation during inflammation.ZBP-89 regulates of MMP-1 expression.ZBP-89 and NF-kappaB appear to bind cooperatively on both promoters. | Zinc-binding protein-89 (ZBP-89) cooperates with NF-κB to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines.
Borghaei RC, Gorski G, Seutter S, Chun J, Khaselov N, Scianni S. | 11/12/2016 |
| ZBP-89 attenuates HDAC3 by increasing IkappaB degradation, dependent on Pin1 but independent of NF-Kappab | ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1.
Ye CG, Liu L, Chen GG, Tang XL, He Z, He ML, Lai PB., Free PMC Article | 04/16/2016 |
| zinc-binding protein-89 upregulates the expression of Bak by targeting multiple components of the epigenetic pathway in hepatocellular carcinoma. | Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.
Ye CG, Chen GG, Ho RLK, Merchant JL, He ML, Lai PBS., Free PMC Article | 03/1/2014 |
| lower expression of ZNF148 in colorectal cancer was significantly associated with worse clinicopathologic variables, including lymph node metastases, poor differentiation, and a higher rate of disease recurrence | Expression of ZNF148 in different developing stages of colorectal cancer and its prognostic value: a large Chinese study based on tissue microarray.
Gao XH, Liu QZ, Chang W, Xu XD, Du Y, Han Y, Liu Y, Yu ZQ, Zuo ZG, Xing JJ, Cao G, Fu CG. | 08/31/2013 |
| this study provides vigorous evidence that ZBP-89 was significantly downregulated in clear cell renal cell carcinoma(CCRCC) and could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC. | High-expression of ZBP-89 correlates with distal metastasis and poor prognosis of patients in clear cell renal cell carcinoma.
Cai MY, Luo RZ, Li YH, Dong P, Zhang ZL, Zhou FJ, Chen JW, Yun JP, Zhang CZ, Cao Y. | 02/16/2013 |
| Colony formation was reduced dramatically in those hepatocellular carcinoma cell lines in which ZBP-89 overexpression was demonstrated; this appeared to correlate with increased apoptosis. | Increased expression of ZBP-89 and its prognostic significance in hepatocellular carcinoma.
Zhang CZ, Cao Y, Yun JP, Chen GG, Lai PB. | 09/29/2012 |
| We found that the TP53-G245D variant but not TP53-R249S abrogated HDAC inhibitor p21 induction by binding to ZBP-89 and retaining it in the cytoplasm. | Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma.
Zhang CZ, Chen GG, Merchant JL, Lai PB., Free PMC Article | 09/1/2012 |
| ZBP-89 is a regulator of Pdcd4 gene, binding to the basal promoter either alone or by interacting with Sp family members. | Promoter cloning and characterization of the human programmed cell death protein 4 (pdcd4) gene: evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators.
Leupold JH, Asangani IA, Mudduluru G, Allgayer H. | 07/21/2012 |
| An activating role for ZBP-89 in human globin gene regulation and erythroid differentiation. | Role of ZBP-89 in human globin gene regulation and erythroid differentiation.
Woo AJ, Kim J, Xu J, Huang H, Cantor AB., Free PMC Article | 12/3/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Alternative binding of ZBP89 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner. | Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter.
Udelhoven M, Pasieka M, Leeser U, Krone W, Schubert M. | 03/8/2010 |