| Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells. | Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells.
Kim HJ, Hong JH., Free PMC Article | 08/19/2023 |
| Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma. | Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma.
Ning WR, Jiang D, Liu XC, Huang YF, Peng ZP, Jiang ZZ, Kang T, Zhuang SM, Wu Y, Zheng L., Free PMC Article | 04/9/2022 |
| Carbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells. | Carbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells.
Huang T, Tang L, Wang H, Lin L, Fu J., Free PMC Article | 02/19/2022 |
| Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling. | Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling.
Vergara D, Ravaioli S, Fonzi E, Adamo L, Damato M, Bravaccini S, Pirini F, Gaballo A, Barbano R, Pasculli B, Franck J, Fournier I, Salzet M, Maffia M., Free PMC Article | 10/10/2020 |
| CA12 plays vital roles in occurrence of congenital bilateral absence of vas deferens | SCNN1B and CA12 play vital roles in occurrence of congenital bilateral absence of vas deferens (CBAVD).
Shen Y, Yue HX, Li FP, Hu FY, Li XL, Wan Q, Zhao WR, Jing JG, Cai DM, Jiang XH., Free PMC Article | 08/12/2020 |
| Knockout of GLI1 and CAXII significantly decreased hallmarks of tumor aggressiveness including proliferation and migration. | Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells.
Guerrini G, Durivault J, Filippi I, Criscuoli M, Monaci S, Pouyssegur J, Naldini A, Carraro F, Parks SK. | 07/4/2020 |
| Our results may contribute to further understand the physiology of Breast cancer (BC) cells and indicate that the Hh pathway controls Breast cancer (BC) cell migration and cell invasion also through CAXII, with important implications in identifying novel therapeutic targets. | Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration.
Guerrini G, Criscuoli M, Filippi I, Naldini A, Carraro F. | 10/5/2019 |
| CA12 was significant higher expressing in breast cancer tissues | High expression of carbonic anhydrase 12 (CA12) is associated with good prognosis in breast cancer.
Li Y, Lei B, Zou J, Wang W, Chen A, Zhang J, Fu Y, Li Z. | 09/14/2019 |
| Our newly identified humanized CA12-antibody with anti-cancer activity, represents a new tool for the treatment of CA12-positive tumors. | Humanized Monoclonal Antibody Blocking Carbonic Anhydrase 12 Enzymatic Activity Leads to Reduced Tumor Growth In Vitro.
Uda NR, Stenner F, Seibert V, Herzig P, Markuly N, VAN Dijk M, Zippelius A, Renner C. | 08/10/2019 |
| Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition. | Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.
Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC., Free PMC Article | 04/20/2019 |
| CAIX and CAXII expression are diagnostic for breast cancer subtype and prognosticators of patient survival. Overall, we show that CAIX but not CAXII drives growth, migration, and metastasis consistent with its expression in more aggressive breast cancers. | Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells.
Chen Z, Ai L, Mboge MY, Tu C, McKenna R, Brown KD, Heldermon CD, Frost SC., Free PMC Article | 01/5/2019 |
| CAII, CAIX, and CAXII all have characteristic expression patterns in esophageal adenocarcinoma (EAC), its precursors and normal squamous epithelium. In EAC, CAII downregulation is associated with metastatic disease. CAIX expression is lost towards the more malignant lesions, but in lymph node positive disease, expression seems to be higher. CAXII is only expressed in normal esophageal epithelium. | Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma.
Nortunen M, Huhta H, Helminen O, Parkkila S, Kauppila JH, Karttunen TJ, Saarnio J. | 11/10/2018 |
| Our findings indicate that loss of CA XII function should be considered in individuals without CFTR mutations who exhibit CF-like features in the sweat gland and lung. | Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease.
Lee M, Vecchio-Pagán B, Sharma N, Waheed A, Li X, Raraigh KS, Robbins S, Han ST, Franca AL, Pellicore MJ, Evans TA, Arcara KM, Nguyen H, Luan S, Belchis D, Hertecant J, Zabner J, Sly WS, Cutting GR., Free PMC Article | 07/29/2017 |
| The expression of HIF-1alpha, but not HIF-2alpha, decreased in degenerated disc samples and was positively correlated with carbonic anhydrase 12 expression. | PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study.
Chen S, Fang XQ, Wang Q, Wang SW, Hu ZJ, Zhou ZJ, Xu WB, Wang JY, Qin A, Fan SW. | 06/24/2017 |
| CA II and CA XII, but not CA VII or CA IX, could be useful in predicting survival in colorectal carcinomas | Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.
Viikilä P, Kivelä AJ, Mustonen H, Koskensalo S, Waheed A, Sly WS, Pastorek J, Pastorekova S, Parkkila S, Haglund C., Free PMC Article | 05/20/2017 |
| CAIX mRNA expression was significantly higher (p < 0.05) in hypoxia for all cell lines, which was in agreement with protein expression by ICC. CAXII expression was mixed, with a modest hypoxia-related increase in two cell lines (p < 0.05) and no change in others. | Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia.
Tafreshi NK, Lloyd MC, Proemsey JB, Bui MM, Kim J, Gillies RJ, Morse DL., Free PMC Article | 12/17/2016 |
| mutation CA12(E143K) causes mouth dryness disease due to aberrant CA12 glycosylation. | Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation.
Hong JH, Muhammad E, Zheng C, Hershkovitz E, Alkrinawi S, Loewenthal N, Parvari R, Muallem S., Free PMC Article | 10/8/2016 |
| Suggest CAXII as a new secondary marker of the multidrug resistance phenotype that influences Pgp activity directly. | Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells.
Kopecka J, Campia I, Jacobs A, Frei AP, Ghigo D, Wollscheid B, Riganti C., Free PMC Article | 01/23/2016 |
| A critical role for re-oxygenation on CAIX and CAXII levels that may select for an aggressive lung cancer phenotype. | Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients.
Ilie M, Hofman V, Zangari J, Chiche J, Mouroux J, Mazure NM, Pouysségur J, Brest P, Hofman P. | 04/19/2014 |
| an upregulation of CAXII in human T-cell acute lymphoblastic leukemia samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL. | Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas.
Lounnas N, Rosilio C, Nebout M, Mary D, Griessinger E, Neffati Z, Chiche J, Spits H, Hagenbeek TJ, Asnafi V, Poulsen SA, Supuran CT, Peyron JF, Imbert V. | 06/22/2013 |
| Serum CAXII levels were significantly higher in lung cancer patients than in healthy controls, providing evidence that CAXII may be a novel sero-diagnostic marker for lung cancer. | CAXII Is a sero-diagnostic marker for lung cancer.
Kobayashi M, Matsumoto T, Ryuge S, Yanagita K, Nagashio R, Kawakami Y, Goshima N, Jiang SX, Saegusa M, Iyoda A, Satoh Y, Masuda N, Sato Y., Free PMC Article | 08/18/2012 |
| The expression of CA XII in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and survival of OSCC patients. | Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis.
Chien MH, Ying TH, Hsieh YH, Lin CH, Shih CH, Wei LH, Yang SF. | 08/4/2012 |
| The development of acidosis with topiramate and zonisamide is not determined by drug dose or by treatment duration, but may be influenced by polymorphisms in the gene for CA type XII. | Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.
Mirza NS, Alfirevic A, Jorgensen A, Marson AG, Pirmohamed M. | 08/6/2011 |
| Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12.Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12. | Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions.
Davidson B, Stavnes HT, Holth A, Chen X, Yang Y, Shih IeM, Wang TL., Free PMC Article | 07/23/2011 |
| Study identified the association of a Glu143Lys mutation in carbonic anhydrase 12 (CA12) with the disease. | Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12.
Muhammad E, Leventhal N, Parvari G, Hanukoglu A, Hanukoglu I, Chalifa-Caspi V, Feinstein Y, Weinbrand J, Jacoby H, Manor E, Nagar T, Beck JC, Sheffield VC, Hershkovitz E, Parvari R. | 06/18/2011 |