| The Roles of ZnT1 and ZnT4 in Glucose-Stimulated Zinc Secretion in Prostate Epithelial Cells. | The Roles of ZnT1 and ZnT4 in Glucose-Stimulated Zinc Secretion in Prostate Epithelial Cells.
Lo ST, Parrott D, Jordan MVC, Joseph DB, Strand D, Lo UG, Lin H, Darehshouri A, Sherry AD., Free PMC Article | 11/13/2021 |
| There was a significant increase in protein levels of ZnT4 in the prefrontal cortex in Major depression disorder, relative to control subjects. | Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.
Rafalo-Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa-Kucma M, Misztak P, Rajkowska G, Stockmeier CA, Datka W, Nowak G, Szewczyk B., Free PMC Article | 09/23/2017 |
| TRPML1 works in concert with ZnT4 to regulate zinc translocation between the cytoplasm and lysosomes. | Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter.
Kukic I, Lee JK, Coblentz J, Kelleher SL, Kiselyov K., Free PMC Article | 06/1/2013 |
| The loss of ZnT4 in airway inflammation contributes to airway epithelium vulnerability in diseases such as asthma. | Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation.
Murgia C, Grosser D, Truong-Tran AQ, Roscioli E, Michalczyk A, Ackland ML, Stoltenberg M, Danscher G, Lang C, Knight D, Perozzi G, Ruffin RE, Zalewski P., Free PMC Article | 05/19/2012 |
| our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms | Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.
Lyubartseva G, Smith JL, Markesbery WR, Lovell MA., Free PMC Article | 08/16/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. | 09/24/2008 |
| Data show that ZNT4 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. | Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.
Zhang LH, Wang X, Stoltenberg M, Danscher G, Huang L, Wang ZY. | 01/21/2010 |
| hZnT-4 is found in the plasma membrane. It is most highly expressed in Molt-4 cells, up-regulated after treatment with phytohemagglutinin & is responsible for the measured decrease of intracellular zinc content after high zinc exposure. | Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.
Overbeck S, Uciechowski P, Ackland ML, Ford D, Rink L. | 01/21/2010 |
| Decreased hZnT-4 expression is associated with prostate tissue abnormalities independent of total cellular zinc content. | Differential expression of hZnT-4 in human prostate tissues.
Beck FW, Prasad AS, Butler CE, Sakr WA, Kucuk O, Sarkar FH. | 01/21/2010 |
| hZnT4 is constitutively expressed in the human breast and may be one of the several members of the ZnT family involved in the transport of zinc into milk | Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells.
Michalczyk AA, Allen J, Blomeley RC, Ackland ML., Free PMC Article | 01/21/2010 |
| The hZnT4 protein did not co-localise with intracellular free zinc pools, suggesting that hZnT4 is not involved in transport of zinc into vesicles destined for secretion into milk. | Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk.
Michalczyk A, Varigos G, Catto-Smith A, Blomeley RC, Ackland ML. | 01/21/2010 |
| decreased intensity of ZnT4 immunoreactivity occurred in the progression from benign to invasive localized prostate cancer and to metastatic disease | Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer.
Henshall SM, Afar DE, Rasiah KK, Horvath LG, Gish K, Caras I, Ramakrishnan V, Wong M, Jeffry U, Kench JG, Quinn DI, Turner JJ, Delprado W, Lee CS, Golovsky D, Brenner PC, O'Neill GF, Kooner R, Stricker PD, Grygiel JJ, Mack DH, Sutherland RL. | 01/21/2010 |
| findings implicate a role for ZnT(4) in mast cell Zn homeostasis and suggest that granule pools of Zn may be distinct from those regulating activation of procaspase-3 and NF-kappaB. | Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation.
Ho LH, Ruffin RE, Murgia C, Li L, Krilis SA, Zalewski PD. | 01/21/2010 |
| Our results show that Zn transporter-4 and Zn transporter-6 are significantly (P<0.05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. | Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain.
Smith JL, Xiong S, Markesbery WR, Lovell MA. | 01/21/2010 |
| not responsible for acrodermatitis enteropathica in Japanese families | ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families.
Nakano A, Nakano H, Hanada K, Nomura K, Uitto J. | 01/21/2010 |
| Genomic localization, organization; exclusion in variants of acrodermatitis enteropathica. | Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica.
Bleck O, Ashton GH, Mallipeddi R, South AP, Whittock NV, McLean WH, Atherton DJ, McGrath JA. | 01/21/2010 |