| Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida. | Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida.
Sun L, Tong K, Liu W, Tian Y, Liu D, Huang G, Li J. | 05/5/2023 |
| Novel mutations in TUBB8 and ZP3 cause human oocyte maturation arrest and female infertility. | Novel mutations in TUBB8 and ZP3 cause human oocyte maturation arrest and female infertility.
Li W, Li Q, Xu X, Wang C, Hu K, Xu J. | 12/3/2022 |
| Novel mutations in ZP2 and ZP3 cause female infertility in three patients. | Novel mutations in ZP2 and ZP3 cause female infertility in three patients.
Jia W, Xi Q, Zhu L, Luo Y, Li Z, Hou M, Zhang D, Yang X, Hu J, Jin L, Zhang X., Free PMC Article | 05/21/2022 |
| A novel gene mutation in ZP3 loop region identified in patients with empty follicle syndrome. | A novel gene mutation in ZP3 loop region identified in patients with empty follicle syndrome.
Zhang Z, Guo Q, Jia L, Zhou C, He S, Fang C, Zhang M, Sun P, Zeng Z, Wang M, Wang D, Liang X. | 05/7/2022 |
| Novel expression of zona pellucida 3 protein in normal testis; potential functional implications. | Novel expression of zona pellucida 3 protein in normal testis; potential functional implications.
Pulawska K, Ponikwicka-Tyszko D, Lebiedzinska W, Guo P, Bernaczyk P, Pilaszewicz-Puza A, Li X, Chrusciel M, Lupu O, Leskinen S, Makela JA, Toppari J, Wolczynski S, Coelingh Bennink HJT, Huhtaniemi I, Rahman NA. | 04/2/2022 |
| A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility. | A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility.
Sun Y, Zeng Y, Chen H, Zhou Z, Fu J, Sang Q, Wang L, Sun X, Chen B, Xu C., Free PMC Article | 09/11/2021 |
| A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation. | A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation.
Zhang D, Zhu L, Liu Z, Ren X, Yang X, Li D, Luo Y, Peng X, Zhou X, Jia W, Hou M, Li Z, Jin L, Zhang X., Free PMC Article | 07/3/2021 |
| Zona Pellucida Proteins, Fibrils, and Matrix. | Zona Pellucida Proteins, Fibrils, and Matrix.
Litscher ES, Wassarman PM. | 06/5/2021 |
| Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human. | Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human.
Cao Q, Zhao C, Zhang X, Zhang H, Lu Q, Wang C, Hu Y, Ling X, Zhang J, Huo R., Free PMC Article | 05/15/2021 |
| Mutations in ZP1, ZP2, and ZP3 might affect the corresponding protein expression, secretion, and interaction, thus providing a mechanistic explanation for the phenotypes for female infertility. | Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation.
Zhou Z, Ni C, Wu L, Chen B, Xu Y, Zhang Z, Mu J, Li B, Yan Z, Fu J, Wang W, Zhao L, Dong J, Sun X, Kuang Y, Sang Q, Wang L. | 05/25/2019 |
| The zona pellucida-3 (ZP3) protein plays a pivotal role in oocyte and gamete development. | Efficient production of human zona pellucida-3 in a prokaryotic expression system.
Qiu Z, Wang M, She M, Chen Q, Li Q, Zhu J, Yang X, Cai X. | 11/3/2018 |
| The oocyte ZP3 expression was the main predictor of the fertilization capacity. | Zona pellucida gene mRNA expression in human oocytes is related to oocyte maturity, zona inner layer retardance and fertilization competence.
Canosa S, Adriaenssens T, Coucke W, Dalmasso P, Revelli A, Benedetto C, Smitz J. | 02/24/2018 |
| Missense Mutation in ZP3 gene is associated with Empty Follicle Syndrome and Female Infertility. | A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.
Chen T, Bian Y, Liu X, Zhao S, Wu K, Yan L, Li M, Yang Z, Liu H, Zhao H, Chen ZJ., Free PMC Article | 10/28/2017 |
| Mutations in ZP2 and ZP3 have dosage effects which can cause female infertility in humans. | Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.
Liu W, Li K, Bai D, Yin J, Tang Y, Chi F, Zhang L, Wang Y, Pan J, Liang S, Guo Y, Ruan J, Kou X, Zhao Y, Wang H, Chen J, Teng X, Gao S. | 08/12/2017 |
| Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. | Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3.
Maldera JA, Weigel Muñoz M, Chirinos M, Busso D, G E Raffo F, Battistone MA, Blaquier JA, Larrea F, Cuasnicu PS. | 11/22/2014 |
| observed sequence variations in exons of ZP3 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] | Genetic and physiological study of morphologically abnormal human zona pellucida.
Margalit M, Paz G, Yavetz H, Yogev L, Amit A, Hevlin-Schwartz T, Gupta SK, Kleiman SE. | 04/27/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| The functional activity of human ZP3 resides in its C-terminal domain. | Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus.
Bansal P, Chakrabarti K, Gupta SK. | 01/21/2010 |
| a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera | DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies.
Choudhury S, Ganguly A, Chakrabarti K, Sharma RK, Gupta SK. | 01/21/2010 |
| may have a role in the development of primordial follicle before zona pellucida formation | Zona pellucida components are present in human fetal ovary before follicle formation.
Törmälä RM, Jääskeläinen M, Lakkakorpi J, Liakka A, Tapanainen JS, Vaskivuo TE. | 01/21/2010 |
| induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent | Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa.
Chiu PC, Wong BS, Chung MK, Lam KK, Pang RT, Lee KF, Sumitro SB, Gupta SK, Yeung WS. | 01/21/2010 |
| ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. | Detection of zona pellucida proteins during human folliculogenesis.
Gook DA, Edgar DH, Borg J, Martic M. | 01/21/2010 |
| Peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 have a role similar to human ZP3. The mechanism of the response to the peptides involves influx of calcium, the G protein pathway, and a T-type calcium channel. | Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism.
Ni Y, Li K, Xu W, Song L, Yao K, Zhang X, Huang H, Zhang Y, Shi QX. | 01/21/2010 |
| human and mouse ZP3 proteins are quite similar, and alternative explanations of taxon-specific sperm binding warrant exploration | Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.
Zhao M, Boja ES, Hoodbhoy T, Nawrocki J, Kaufman JB, Kresge N, Ghirlando R, Shiloach J, Pannell L, Levine RL, Fales HM, Dean J. | 01/21/2010 |
| Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. | Biological effects of recombinant human zona pellucida proteins on sperm function.
Caballero-Campo P, Chirinos M, Fan XJ, González-González ME, Galicia-Chavarría M, Larrea F, Gerton GL. | 01/21/2010 |