| Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress cell proliferation and invasion in prostate cancer by regulating MAP3K12 | Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.
Yu J, Feng Y, Wang Y, An R. | 07/6/2019 |
| LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. | Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ., Free PMC Article | 08/5/2017 |
| REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase | Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase.
Oetjen E. | 03/25/2017 |
| miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function. | MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function.
Ye M, Li D, Yang J, Xie J, Yu F, Ma Y, Zhu X, Zhao J, Lv Z. | 02/27/2016 |
| Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration. | Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.
Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, Ly CQ, Lyssikatos JP, Ma C, Scearce-Levie K, Shin YG, Solanoy H, Stark KL, Wang J, Wang B, Zhao X, Lewcock JW, Siu M. | 05/2/2015 |
| these findings indicate that DLK participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins. | Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest.
Daviau A, Couture JP, Blouin R. | 12/10/2011 |
| The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK expression and the clinical course of the disease. | Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors.
Bojarska-Junak A, Sieklucka M, Hus I, Wąsik-Szczepanek E, Kusz ML, Surdacka A, Chocholska S, Dmoszyńska A, Roliński J. | 10/29/2011 |
| the DLK-ERK signaling pathway may act as a regulator of the interaction that occurs between Hsp27 and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function | The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression.
Robitaille H, Simard-Bisson C, Larouche D, Tanguay RM, Blouin R, Germain L. | 02/1/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Genetic variation in MicroRNA genes and risk of oral premalignant lesions.
Clague J, Lippman SM, Yang H, Hildebrandt MA, Ye Y, Lee JJ, Wu X., Free PMC Article | 12/2/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M., Free PMC Article | 12/2/2009 |
| Src-dependent tyrosine phosphorylation recombinant human DLK was important for regulation of its activity. DLK may have a role in PDGF signaling. | The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF).
Daviau A, Di Fruscio M, Blouin R. | 01/21/2010 |
| DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression. | DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.
Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL., Free PMC Article | 01/21/2010 |
| for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity | SP3 acts as a positive regulator on the core promoter of human ZPK gene.
Itoh A, Wang Z, Ito Y, Reddy UR, Itoh T. | 01/21/2010 |
| DLK is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification | The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.
Robitaille H, Proulx R, Robitaille K, Blouin R, Germain L. | 01/21/2010 |
| ZIPK is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity. | Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation.
Graves PR, Winkfield KM, Haystead TA. | 01/21/2010 |