| Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-kappaB inactivation. | Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation.
Cho MJ, Lee DG, Lee JW, Hwang B, Yoon SJ, Lee SJ, Park YJ, Park SH, Lee HG, Kim YH, Lee CH, Lee J, Lee NK, Han TS, Cho HS, Moon JH, Lee GS, Bae KH, Hwang GS, Lee SH, Chung SJ, Shim S, Cho J, Oh GT, Kwon YG, Park JG, Min JK., Free PMC Article | 08/25/2023 |
| GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1. | GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1.
Hu H, Ye L, Liu Z., Free PMC Article | 04/2/2022 |
| LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR-186-5p/PTP4A1 axis in cholangiocarcinoma. | LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR-186-5p/PTP4A1 axis in cholangiocarcinoma.
Li O, Jiang B, Yi WM, Zhang Y, Yang PZ, Guo C, Sun ZP, Peng C. | 01/8/2022 |
| These results provide evidence indicating a regulatory role of PRL-1 during Immunological Synapse assembly and highlight the involvement of PRLs in immune responses by mature T cells. | Phosphatase of Regenerating Liver-1 (PRL-1) Regulates Actin Dynamics During Immunological Synapse Assembly and T Cell Effector Function.
Castro-Sánchez P, Ramirez-Munoz R, Martín-Cófreces NB, Aguilar-Sopeña O, Alegre-Gomez S, Hernández-Pérez S, Reyes R, Zeng Q, Cabañas C, Sánchez-Madrid F, Roda-Navarro P., Free PMC Article | 10/5/2019 |
| Overexpression of miR-339-5p enhanced radiosensitivity of A549 and H460 cells by inhibiting cell viability, increasing apoptosis, inducing cell cycle arrest, and suppressing cell proliferation. Further exploration validated that miR-339-5p can target phosphatases of regenerating liver-1 (PRL-1) in lung cancer cells. | miR-339-5p Increases Radiosensitivity of Lung Cancer Cells by Targeting Phosphatases of Regenerating Liver-1 (PRL-1).
Wang J, Jiang M, Xia S., Free PMC Article | 02/2/2019 |
| PRL mRNA transcription was stimulated by Mg(2+) depletion. A series of analyses revealed the activation and the crucial importance of signal transducer and activator of transcription 1 in this process. Collectively, these results implicate PRL in maintaining cellular Mg(2+) homeostasis. | Phosphatase of regenerating liver maintains cellular magnesium homeostasis.
Yoshida A, Funato Y, Miki H. | 01/12/2019 |
| PTP4A1 is a direct downstream target of miR-1271 in the hepatocellular carcinoma. | MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis.
Li C, Jiang Y, Miao R, Qu K, Zhang J, Liu C. | 08/11/2018 |
| PTP4A1 is highly expressed in fibroblasts from patients with systemic sclerosis and enhances pro-fibrotic TGFbeta signaling in these cells. | PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N., Free PMC Article | 05/5/2018 |
| PTP4A1 was overexpressed in ICC and played an important role in the progression and metastasis of ICC. The functional role of PTP4A1 was assumed to be acted by activation PI3K/AKT signaling and promoting the EMT process through two pivotal transcriptional factors Zeb1 and Snail. | Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway.
Liu LZ, He YZ, Dong PP, Ma LJ, Wang ZC, Liu XY, Duan M, Yang LX, Shi JY, Zhou J, Fan J, Gao Q, Wang XY., Free PMC Article | 03/3/2018 |
| Results showed that SIAH1 and PTP4A1 expression was regulated by mir-944 in breast cancer cells. miR-944 binds directly the 3 UTR of their promotor region. | Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells.
Flores-Pérez A, Marchat LA, Rodríguez-Cuevas S, Bautista VP, Fuentes-Mera L, Romero-Zamora D, Maciel-Dominguez A, de la Cruz OH, Fonseca-Sánchez M, Ruíz-García E, la Vega HA, López-Camarillo C., Free PMC Article | 10/21/2017 |
| miR-601 inhibits growth and invasion of breast cancer cells by targeting PTP4A1. | miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer.
Hu JY, Yi W, Wei X, Zhang MY, Xu R, Zeng LS, Huang ZJ, Chen JS. | 12/31/2016 |
| Data indicate that protein-tyrosine-phosphatase of regenerating liver 1 (PRL1) gene was expressed much more highly in prostate cancer (PCa) than in nonneoplastic prostate samples. | Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method.
Shinmei S, Sentani K, Hayashi T, Sakamoto N, Goto K, Oo HZ, Naito Y, Teishima J, Matsubara A, Oue N, Kuniyasu H, Yasui W. | 05/16/2015 |
| Upregulation of PRL-1 expression is inversely correlated with miR-26a in primary cervical cancer tissues. | MicroRNA-26a inhibits cell proliferation and invasion of cervical cancer cells by targeting protein tyrosine phosphatase type IVA 1.
Dong J, Sui L, Wang Q, Chen M, Sun H. | 05/16/2015 |
| Data highlight the oncogenic function of PRL-1 in HCC invasion and metastasis. | Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma.
Jin S, Wang K, Xu K, Xu J, Sun J, Chu Z, Lin D, Koeffler PH, Wang J, Yin D., Free PMC Article | 04/25/2015 |
| We confirmed with our previous findings that PTP4A1-PHF3-EYS variants were significantly associated with alcohol dependence. | Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence.
Zuo L, Wang K, Wang G, Pan X, Zhang X, Zhang H, Luo X., Free PMC Article | 02/28/2015 |
| PTP4A1-PHF3-EYS variants were associated with alcohol dependence. | Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence.
Zuo L, Zhang X, Deng HW, Luo X. | 11/30/2013 |
| Results suggest that TRP32 maintains the reduced state of PRL and thus regulates the biological function of PRL. | Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL).
Ishii T, Funato Y, Miki H., Free PMC Article | 05/4/2013 |
| Studies indicate that PRL-1 and PRL-2 and PRL-3 are oncogenes and belong to the few phosphatases that lead to the development of cancer. | Molecular mechanisms of the PRL phosphatases.
Rios P, Li X, Köhn M. | 04/13/2013 |
| upregulation of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma | Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma.
Lu JW, Chang JG, Yeh KT, Chen RM, Tsai JJ, Su WW, Hu RM. | 08/18/2012 |
| Data conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder. | A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.
Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X., Free PMC Article | 04/14/2012 |
| PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation | PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY., Free PMC Article | 02/25/2012 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)., Free PMC Article | 09/15/2010 |
| Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion. | PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways.
Luo Y, Liang F, Zhang ZY., Free PMC Article | 06/28/2010 |
| phosphatase of regenerating liver activity is controlled by the redox environment and its C-terminal residues | Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues.
Skinner AL, Vartia AA, Williams TD, Laurence JS., Free PMC Article | 01/21/2010 |
| the new oncogenic p53 target, PRL-1, may contribute to tumor development by the downregulation of p53 by a negative feedback mechanism. | New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53.
Min SH, Kim DM, Heo YS, Kim YI, Kim HM, Kim J, Han YM, Kim IC, Yoo OJ. | 01/21/2010 |