| TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3. | TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3.
Wen J, Wang Q, Zhang W, Wang W. | 01/6/2024 |
| TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics. | TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics.
Hoff KJ, Aiken JE, Gutierrez MA, Franco SJ, Moore JK., Free PMC Article | 07/2/2022 |
| Complementing the phenotypical spectrum of TUBA1A tubulinopathy and its role in early-onset epilepsies. | Complementing the phenotypical spectrum of TUBA1A tubulinopathy and its role in early-onset epilepsies.
Schröter J, Popp B, Brennenstuhl H, Döring JH, Donze SH, Bijlsma EK, van Haeringen A, Huhle D, Jestaedt L, Merkenschlager A, Arelin M, Gräfe D, Neuser S, Oates S, Pal DK, Parker MJ, Lemke JR, Hoffmann GF, Kölker S, Harting I, Syrbe S., Free PMC Article | 05/7/2022 |
| alphaTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion. | αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion.
Yoshimoto S, Morita H, Okamura K, Hiraki A, Hashimoto S., Free PMC Article | 02/19/2022 |
| Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development. | Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development.
Jurgens JA, Barry BJ, Lemire G, Chan WM, Whitman MC, Shaaban S, Robson CD, MacKinnon S, England EM, McMillan HJ, Kelly C, Pratt BM, Care4Rare Canada Consortium, O'Donnell-Luria A, MacArthur DG, Boycott KM, Hunter DG, Engle EC., Free PMC Article | 01/22/2022 |
| Novel proteins associated with chronic intermittent hypoxia and obstructive sleep apnea: From rat model to clinical evidence. | Novel proteins associated with chronic intermittent hypoxia and obstructive sleep apnea: From rat model to clinical evidence.
Tang X, Li S, Yang X, Tang Q, Zhang Y, Zeng S, Li M, Jiang K, Guo L, Huang P., Free PMC Article | 11/22/2021 |
| Elevated TUBA1A Might Indicate the Clinical Outcomes of Patients with Gastric Cancer, Being Associated with the Infiltration of Macrophages in the Tumor Immune Microenvironment. | Elevated TUBA1A Might Indicate the Clinical Outcomes of Patients with Gastric Cancer, Being Associated with the Infiltration of Macrophages in the Tumor Immune Microenvironment.
Wang D, Jiao Z, Ji Y, Zhang S. | 10/9/2021 |
| Tubulin mutations in brain development disorders: Why haploinsufficiency does not explain TUBA1A tubulinopathies. | Tubulin mutations in brain development disorders: Why haploinsufficiency does not explain TUBA1A tubulinopathies.
Aiken J, Buscaglia G, Aiken AS, Moore JK, Bates EA. | 09/18/2021 |
| HDAC6-mediated alpha-tubulin deacetylation suppresses autophagy and enhances motility of podocytes in diabetic nephropathy. | HDAC6-mediated α-tubulin deacetylation suppresses autophagy and enhances motility of podocytes in diabetic nephropathy.
Liang T, Qi C, Lai Y, Xie J, Wang H, Zhang L, Lin T, Jv M, Li J, Wang Y, Zhang Y, Chen Z, Qiu X, Li R, Li Z, Ye Z, Liu S, Liang X, Shi W, Wang W., Free PMC Article | 05/8/2021 |
| Microcephaly with a simplified gyral pattern in a child with a de novo TUBA1A variant. | Microcephaly with a simplified gyral pattern in a child with a de novo TUBA1A variant.
Wei H, Krishnappa J, Lin G, Kavalloor N, Lim JY, Goh CJ, Jamuar SS, Thomas T, Tan EC. | 01/9/2021 |
| Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. | Mutations disrupting neuritogenesis genes confer risk for cerebral palsy.
Jin SC, Lewis SA, Bakhtiari S, Zeng X, Sierant MC, Shetty S, Nordlie SM, Elie A, Corbett MA, Norton BY, van Eyk CL, Haider S, Guida BS, Magee H, Liu J, Pastore S, Vincent JB, Brunstrom-Hernandez J, Papavasileiou A, Fahey MC, Berry JG, Harper K, Zhou C, Zhang J, Li B, Zhao H, Heim J, Webber DL, Frank MSB, Xia L, Xu Y, Zhu D, Zhang B, Sheth AH, Knight JR, Castaldi C, Tikhonova IR, López-Giráldez F, Keren B, Whalen S, Buratti J, Doummar D, Cho M, Retterer K, Millan F, Wang Y, Waugh JL, Rodan L, Cohen JS, Fatemi A, Lin AE, Phillips JP, Feyma T, MacLennan SC, Vaughan S, Crompton KE, Reid SM, Reddihough DS, Shang Q, Gao C, Novak I, Badawi N, Wilson YA, McIntyre SJ, Mane SM, Wang X, Amor DJ, Zarnescu DC, Lu Q, Xing Q, Zhu C, Bilguvar K, Padilla-Lopez S, Lifton RP, Gecz J, MacLennan AH, Kruer MC., Free PMC Article | 11/28/2020 |
| Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
Han H, Schubert HL, McCullough J, Monroe N, Purdy MD, Yeager M, Sundquist WI, Hill CP., Free PMC Article | 09/19/2020 |
| the palmitoylation level of Rasrelated protein Rab7a (Rab7a) was enhanced by androgen treatment. Palmitoylation of alphatubulin and Rab7a were essential for cell proliferation. Notably, in the supernatant of LNCaP cells, the palmitoylation level of alphatubulin was also increased following androgen treatment. Palmitoylation of alphatubulin may provide a new potential target for the treatment of prostate cancer. | Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants.
Li W, Zhang J, Zou L, Cui J, Su F, Jin J, Xiao F, Liu M, Zhao G. | 04/4/2020 |
| This study examined the crystal structures of human vasohibin 1 and 2 in complex with small vasohibin-binding protein (SVBP) in the absence and presence of different inhibitors and a C-terminal alpha-tubulin peptide. | Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, Bao H, Krichen F, Chen L, Andrieux A, Olieric V, Moutin MJ, Steinmetz MO, Huang H. | 02/29/2020 |
| Knockdown of either beta3-tubulin or alpha-tubulin via siRNA increased lung cancer cell sensitivity to paclitaxel, indicating that these two proteins help cells increase the drug resistance. | Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption.
Wang Y, Zhou Y, Zheng Z, Li J, Yan Y, Wu W., Free PMC Article | 12/14/2019 |
| These data unequivocally show that free tubulin dimers represent the preferred HDAC6 substrate, with a K M value of 0.23 microM and a deacetylation rate over 1,500-fold higher than that of assembled microtubules. | Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules.
Skultetyova L, Ustinova K, Kutil Z, Novakova Z, Pavlicek J, Mikesova J, Trapl D, Baranova P, Havlinova B, Hubalek M, Lansky Z, Barinka C., Free PMC Article | 06/29/2019 |
| Low Tubulin expression is associated with liver cancer. | HIC1 and RassF1A Methylation Attenuates Tubulin Expression and Cell Stiffness in Cancer.
Chen CC, He BC, Chen YL, Lee KD, Tung CH, Hsu CC, Lin PY, Chu PY, Leu YW, Fu WE, Hsiao SH., Free PMC Article | 01/19/2019 |
| A de novo heterozygous c.320A>G [p.(His 107 Arg)] mutation in TUBA1A was identified in a patient with microcephaly, epileptic seizures, and severe developmental delay. | Epileptogenic Brain Malformations and Mutations in Tubulin Genes: A Case Report and Review of the Literature.
Mencarelli A, Prontera P, Stangoni G, Mencaroni E, Principi N, Esposito S., Free PMC Article | 06/23/2018 |
| Given that Spastin engages the MT in two places, we propose that severing occurs by forces exerted on the C-terminal tail of tubulin, which results in a conformational change in tubulin, which releases it from the polymer. | Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.
White SR, Evans KJ, Lary J, Cole JL, Lauring B., Free PMC Article | 06/20/2018 |
| Molecular docking studies revealed that 6f interacted and bound ef fi ciently with the colchicine-binding site of tubulin. In addition, 6f treatment induced G2/M cell cycle arrest dose-dependently and subsequently induced cell apoptosis | 5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human fibrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest.
Zuo D, Pang L, Shen J, Guan Q, Bai Z, Zhang H, Li Y, Lu G, Zhang W, Wu Y. | 03/3/2018 |
| induced pluripotent stem cells (iPSCs) from the umbilical cord and peripheral blood of two lissencephaly patients with different clinical severities carrying alpha tubulin (TUBA1A) missense mutations, were generated. | In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.
Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H., Free PMC Article | 11/11/2017 |
| Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing alpha-tubulin acetylation in breast cancer. | Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer.
Liao XH, Wang JG, Li LY, Zhou DM, Ren KH, Jin YT, Lv L, Yu JG, Yang JY, Lu Q, Zou Q, Yu J, Liu XP, Zhou P., Free PMC Article | 10/28/2017 |
| Results show that Tuba1a plays an essential, noncompensated role in neuronal saltatory migration in vivo and highlight the importance of microtubule flexibility in nucleus-centrosome coupling and neuronal-branching regulation during neuronal migration. | Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.
Belvindrah R, Natarajan K, Shabajee P, Bruel-Jungerman E, Bernard J, Goutierre M, Moutkine I, Jaglin XH, Savariradjane M, Irinopoulou T, Poncer JC, Janke C, Francis F., Free PMC Article | 09/30/2017 |
| data suggest that the TUBA1A mutations disrupting lateral interactions have pronounced dominant-negative effects on microtubule dynamics that are associated with the severe end of the lissencephaly spectrum | TUBA1A mutation can cause a hydranencephaly-like severe form of cortical dysgenesis.
Yokoi S, Ishihara N, Miya F, Tsutsumi M, Yanagihara I, Fujita N, Yamamoto H, Kato M, Okamoto N, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Kojima S, Saitoh S, Kurahashi H, Natsume J., Free PMC Article | 09/24/2016 |
| Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability. | Proteomic Profiling and Functional Characterization of Multiple Post-Translational Modifications of Tubulin.
Liu N, Xiong Y, Ren Y, Zhang L, He X, Wang X, Liu M, Li D, Shui W, Zhou J. | 06/11/2016 |