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    USP7 ubiquitin specific peptidase 7 [ Homo sapiens (human) ]

    Gene ID: 7874, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.

    USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.
    Tang K, Yin T, Deng B, Wang M, Ren Z, Wang S, Liu X, Li H, Wang J, Du Y, Zhou J, Chen Y, Wang Y., Free PMC Article

    10/18/2024
    USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.

    USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
    Zhao B, Xia Z, Yang B, Guo Y, Zhou R, Gu M, Liu M, Li Q, Bai W, Huang J, Zhang X, Zhu C, Leung KT, Chen C, Dong J.

    09/24/2024
    Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase.

    Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase.
    Guan X, Wang Y, Yu W, Wei Y, Lu Y, Dai E, Dong X, Zhao B, Hu C, Yuan L, Luan X, Miao K, Chen B, Cheng XD, Zhang W, Qin JJ., Free PMC Article

    07/31/2024
    Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7.

    Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7.
    Yang Z, Nicholas J.,

    06/14/2024
    Backbone [1]H, [13]C and [15]N resonance assignment of the ubiquitin specific protease 7 catalytic domain (residues 208-554) in complex with a small molecule ligand.

    Backbone (1)H, (13)C and (15)N resonance assignment of the ubiquitin specific protease 7 catalytic domain (residues 208-554) in complex with a small molecule ligand.
    Pandya MJ, Augustyniak W, Cliff MJ, Lindner I, Stinn A, Kahmann J, Temmerman K, Dannatt HRW, Waltho JP, Watson MJ.

    06/5/2024
    The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.

    The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.
    Zhang R, Zhang D, Han F, Song X, Zhang Y, Zhang J, Zhu Q, Qin Y., Free PMC Article

    05/20/2024
    USP7 interacts with and destabilizes oncoprotein SET.

    USP7 interacts with and destabilizes oncoprotein SET.
    Chen J, Jiao Z, Liu Y, Zhang M, Wang D.

    04/30/2024
    USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination.

    USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination.
    Wang N, Xu J, Wang Y, Zhang X, Zhang H., Free PMC Article

    04/18/2024
    Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.

    Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.
    Zhang B, Li J, Wang Y, Liu X, Yang X, Liao Z, Deng S, Deng Y, Zhou Z, Tian Y, Wei W, Meng J, Hu Y, Wan C, Zhang Z, Huang F, Wen L, Wu B, Sun Y, Li Y, Yang K., Free PMC Article

    03/14/2024
    DNA methylation episignature, extension of the clinical features, and comparative epigenomic profiling of Hao-Fountain syndrome caused by variants in USP7.

    DNA methylation episignature, extension of the clinical features, and comparative epigenomic profiling of Hao-Fountain syndrome caused by variants in USP7.
    van der Laan L, Karimi K, Rooney K, Lauffer P, McConkey H, Caro P, Relator R, Levy MA, Bhai P, Mignot C, Keren B, Briuglia S, Sobering AK, Li D, Vissers LELM, Dingemans AJM, Valenzuela I, Verberne EA, Misra-Isrie M, Zwijnenburg PJG, Waisfisz Q, Alders M, Sailer S, Schaaf CP, Mannens MMAM, Sadikovic B, van Haelst MM, Henneman P.

    03/13/2024
    Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3.

    Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3.
    Hu M, Dai C, Sun X, Chen Y, Xu N, Lin Z, Xu S, Cheng C, Tan Z, Bian S, Zheng W.

    02/28/2024
    Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.

    Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
    Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K., Free PMC Article

    02/12/2024
    SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation.

    SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation.
    Su C, Zhang H, Mo J, Liao Z, Zhang B, Zhu P., Free PMC Article

    02/4/2024
    USP7-mediated ERbeta stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung carcinoma.

    USP7-mediated ERβ stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung carcinoma.
    Meng Y, Lin W, Wang N, Wei X, Mei P, Wang X, Zhang C, Huang Q, Liao Y.

    01/17/2024
    USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.

    USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.
    Liu X, Lu R, Yang Q, He J, Huang C, Cao Y, Zhou Z, Huang J, Li L, Chen R, Wang Y, Huang J, Xie R, Zhao X, Yu J., Free PMC Article

    01/6/2024
    USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.

    USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
    Li Z, Zhou G, Li Q, Jiang L, He J, Ye C.

    01/3/2024
    Current and future directions of USP7 interactome in cancer study.

    Current and future directions of USP7 interactome in cancer study.
    Park HB, Baek KH.

    12/21/2023
    USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.

    USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7.
    Lee SH, Chung KC., Free PMC Article

    11/15/2023
    [Pan-cancer analysis of ubiquitin-specific protease 7 and its expression changes in the carcinogenesis of scar ulcer].

    [Pan-cancer analysis of ubiquitin-specific protease 7 and its expression changes in the carcinogenesis of scar ulcer].
    Zhang SY, Ruan JJ, Jin DM, Chen N, Xie WG, Ruan QF.

    11/3/2023
    USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation.

    USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation.
    Le Clorennec C, Lee K, Huo Y, Zage PE., Free PMC Article

    09/30/2023
    USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis.

    USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis.
    Wang Y, Luo X, Wu N, Liao Q, Wang J.

    08/10/2023
    USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm.

    USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm.
    de Carvalho LGA, Komoto TT, Moreno DA, Goes JVC, de Oliveira RTG, de Lima Melo MM, Roa MEGV, Gonçalves PG, Montefusco-Pereira CV, Pinheiro RF, Ribeiro Junior HL., Free PMC Article

    06/30/2023
    USP7 - a crucial regulator of cancer hallmarks.

    USP7 - a crucial regulator of cancer hallmarks.
    Saha G, Roy S, Basu M, Ghosh MK.

    05/22/2023
    Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein.

    Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein.
    Park HB, Min Y, Hwang S, Baek KH.

    05/17/2023
    USP7 controls NGN3 stability and pancreatic endocrine lineage development.

    USP7 controls NGN3 stability and pancreatic endocrine lineage development.
    Manea T, Nelson JK, Garrone CM, Hansson K, Evans I, Behrens A, Sancho R., Free PMC Article

    05/3/2023
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