| A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization. | A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization.
Shaw IW, Kirkwood PM, Rebourcet D, Cousins FL, Ainslie RJ, Livingstone DEW, Smith LB, Saunders PTK, Gibson DA., Free PMC Article | 12/17/2022 |
| Suppression of steroid 5alpha-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma. | Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.
Dou R, Qian J, Wu W, Zhang Y, Yuan Y, Guo M, Wei R, Yang S, Jurczyszyn A, Janz S, Beksac M, Gu C, Yang Y., Free PMC Article | 09/18/2021 |
| Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice | 5α-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores.
Opoku-Acheampong AB, Henningson JN, Beck AP, Lindshield BL., Free PMC Article | 09/16/2017 |
| Exaggerated predisposition to metabolic disorders in female mice, compared with that seen in male mice, after disruption of 5alphaR1 suggests phenotypic changes may be underpinned by altered metabolism of glucocorticoids rather than androgens. | Metabolic dysfunction in female mice with disruption of 5α-reductase 1.
Livingstone DE, Di Rollo EM, Mak TC, Sooy K, Walker BR, Andrew R., Free PMC Article | 07/1/2017 |
| the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration | Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner.
Ford MM, Nickel JD, Kaufman MN, Finn DA., Free PMC Article | 03/12/2016 |
| deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice | Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene.
Tanchuck-Nipper MA, Ford MM, Hertzberg A, Beadles-Bohling A, Cozzoli DK, Finn DA., Free PMC Article | 03/12/2016 |
| transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region. | DNA methylation of the GC box in the promoter region mediates isolation rearing-induced suppression of srd5a1 transcription in the prefrontal cortex.
Araki R, Nishida S, Hiraki Y, Matsumoto K, Yabe T. | 03/5/2016 |
| The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin resistance in male rats and mice are reported. | 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents.
Livingstone DE, Barat P, Di Rollo EM, Rees GA, Weldin BA, Rog-Zielinska EA, MacFarlane DP, Walker BR, Andrew R. | 04/4/2015 |
| The deletion of Type One 5alpha-reductase among female mice attenuates reproductive responding during the estrous cycle. | Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-priming.
Koonce CJ, Frye CA., Free PMC Article | 01/31/2015 |
| These studies showed that 5alphaR1 deletion accelerates the development of hepatic steatosis but may protect against the development of nonalcoholic fatty liver disease-related hepatocellular neoplasia. | Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.
Dowman JK, Hopkins LJ, Reynolds GM, Armstrong MJ, Nasiri M, Nikolaou N, van Houten EL, Visser JA, Morgan SA, Lavery GG, Oprescu A, Hübscher SG, Newsome PN, Tomlinson JW., Free PMC Article | 02/1/2014 |
| Thus, 5alpha-reductase may be required for the estrous cycle variations in affective behavior and 3alpha,5alpha-THP levels of female mice. | Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice.
Koonce CJ, Walf AA, Frye CA., Free PMC Article | 03/31/2012 |
| results suggest that local steroid 5 alpha-reductase 1 messenger RNA expression in Withdrawal Seizure-Prone mouse brain may not change in parallel with local allopregnanolone content or withdrawal severity | Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity.
Roselli CE, Finn TJ, Ronnekleiv-Kelly SM, Tanchuck MA, Kaufman KR, Finn DA., Free PMC Article | 03/3/2012 |
| The aim of the present study was to investigate the role of 5alpha-reductase type 1 for bone mass using Srd5a1-/- mice. | Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice.
Windahl SH, Andersson N, Börjesson AE, Swanson C, Svensson J, Movérare-Skrtic S, Sjögren K, Shao R, Lagerquist MK, Ohlsson C., Free PMC Article | 11/5/2011 |
| Data suggests that in male mice after social isolation, expression of Srd5a1 mRNA is specifically down-regulated in glutamatergic pyramidal neurons. In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders. | Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.
Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A., Free PMC Article | 09/22/2009 |
| social isolation-induced increase of the contextual fear-conditioning response is associated with a marked (50%) down-regulation of 5-RI mRNA expression in the hippocampus, amygdala, and FC. | Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder.
Pibiri F, Nelson M, Guidotti A, Costa E, Pinna G., Free PMC Article | 01/21/2010 |
| This study evaluates 5alpha-R type I and 3alpha-HSD mRNA expression level in mouse brain by using in situ hybridization. | Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A., Free PMC Article | 01/21/2010 |