| Identification of a buried beta-strand as a novel disease-related motif in the human polysialyltransferases. | Identification of a buried β-strand as a novel disease-related motif in the human polysialyltransferases.
Hatanaka R, Hane M, Hayakawa K, Morishita S, Ohno S, Yamaguchi Y, Wu D, Kitajima K, Sato C., Free PMC Article | 02/9/2024 |
| Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 have been described. | Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.
Mori A, Hane M, Niimi Y, Kitajima K, Sato C. | 04/28/2018 |
| our results demonstrate that miR-146a and miR-146b promote proliferation, migration and invasion of FTC via inhibition of ST8SIA4. | miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
Ma W, Zhao X, Liang L, Wang G, Li Y, Miao X, Zhao Y., Free PMC Article | 03/10/2018 |
| Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples. | Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Zhao L, Li Y, Song X, Zhou H, Li N, Miao Y, Jia L., Free PMC Article | 02/10/2018 |
| This is the first report to demonstrate a role for a glycosyltransferase in human pluripotent stem cell lineage specification. | ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells.
Berger RP, Sun YH, Kulik M, Lee JK, Nairn AV, Moremen KW, Pierce M, Dalton S., Free PMC Article | 12/9/2017 |
| changes in the glycosylation patterns and sialylation levels may be useful markers of the progression of breast cancer, as well as miR-26a/26b may be widely involved in the regulation of sialylation machinery by targeting ST8SIA4. | Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
Ma X, Dong W, Su Z, Zhao L, Miao Y, Li N, Zhou H, Jia L., Free PMC Article | 10/14/2017 |
| The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM. | The Polybasic Region of the Polysialyltransferase ST8Sia-IV Binds Directly to the Neural Cell Adhesion Molecule, NCAM.
Bhide GP, Prehna G, Ramirez BE, Colley KJ., Free PMC Article | 05/20/2017 |
| Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. | Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans.
Bhide GP, Fernandes NR, Colley KJ., Free PMC Article | 11/12/2016 |
| ST8SIA4 gene is involved in the development of multidrug resistance via PI3K/Akt pathway in chronic myeloid leukemia. | α-2,8-Sialyltransferase Is Involved in the Development of Multidrug Resistance via PI3K/Akt Pathway in Human Chronic Myeloid Leukemia.
Zhang X, Dong W, Zhou H, Li H, Wang N, Miao X, Jia L. | 04/30/2016 |
| this study indicated that sialylation involved in the development of MDR of AML cells probably through ST3GAL5 or ST8SIA4 regulating the activity of PI3K/Akt signaling and the expression of P-gp and MRP1. | Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia.
Ma H, Zhou H, Song X, Shi S, Zhang J, Jia L. | 04/11/2015 |
| ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans. | Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type o-glycans located between the b2 and c domain.
Rollenhagen M, Buettner FF, Reismann M, Jirmo AC, Grove M, Behrens GM, Gerardy-Schahn R, Hanisch FG, Mühlenhoff M., Free PMC Article | 11/2/2013 |
| The ST8SiaIV/PST polybasic region plays a critical role in substrate recognition. | Sequences prior to conserved catalytic motifs of polysialyltransferase ST8Sia IV are required for substrate recognition.
Zapater JL, Colley KJ., Free PMC Article | 04/28/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| polysialylated NCAM persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy | N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy.
Piccinini M, Buccinnà B, De Marco G, Lupino E, Ramondetti C, Grifoni S, Votta B, Giordana MT, Rinaudo MT., Free PMC Article | 08/16/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM. | Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM.
Foley DA, Swartzentruber KG, Colley KJ., Free PMC Article | 01/21/2010 |
| PSA-NCAM and ST8Sia-II/IV Expression Is Increased in Pancreatic Carcinomas | Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells.
Schreiber SC, Giehl K, Kastilan C, Hasel C, Mühlenhoff M, Adler G, Wedlich D, Menke A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.
Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M. | 03/13/2008 |
| polysialyltransferase ST8Sia IV/PST recognizes specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule | Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST.
Mendiratta SS, Sekulic N, Lavie A, Colley KJ. | 01/21/2010 |
| SIAT8D has a role in neural development and sialic acid synthesis on NCAM | ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes.
Angata K, Suzuki M, Fukuda M. | 01/21/2010 |
| The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported. | Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells.
Beecken WD, Engl T, Ogbomo H, Relja B, Cinatl J, Bereiter-Hahn J, Oppermann E, Jonas D, Blaheta RA. | 01/21/2010 |
| Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR) and acini (PST1) indicating that PST1 is a modifier gene for CFTR-related idiopathic chronic pancreatitis. | Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene.
Cohn JA, Noone PG, Jowell PS. | 01/21/2010 |