| Tracking the transition from an ATG9A vesicle to an autophagosome. | Tracking the transition from an ATG9A vesicle to an autophagosome.
Broadbent D, Barnaba C, Schmidt JC., Free PMC Article | 05/1/2024 |
| NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1. | NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1.
Zhang Z, Song B, Wei H, Liu Y, Zhang W, Yang Y, Sun B. | 03/11/2024 |
| ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A. | ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.
Chiduza GN, Garza-Garcia A, Almacellas E, De Tito S, Pye VE, van Vliet AR, Cherepanov P, Tooze SA., Free PMC Article | 03/11/2024 |
| ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells. | ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells.
Liu X, Liu Z, Liu Y, Wang N., Free PMC Article | 10/5/2023 |
| A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity. | A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity.
Yang Y, Klionsky DJ., Free PMC Article | 06/14/2023 |
| Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation. | Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation.
Broadbent DG, Barnaba C, Perez GI, Schmidt JC., Free PMC Article | 05/15/2023 |
| Atg9A-mediated mitophagy is required for decidual differentiation of endometrial stromal cells. | Atg9A-mediated mitophagy is required for decidual differentiation of endometrial stromal cells.
Li J, Zhang S, Zhang Y, Dai Y, Zhang Y, Yang A, Hong F, Pan Y. | 12/3/2022 |
| RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. | RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery.
Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS., Free PMC Article | 03/26/2022 |
| Ultrasound cardiogram-based diagnosis of cardiac hypertrophy from hypertension and analysis of its relationship with expression of autophagy-related protein. | Ultrasound cardiogram-based diagnosis of cardiac hypertrophy from hypertension and analysis of its relationship with expression of autophagy-related protein.
Li S, Zhao L, Zhang B, Yuan Y, Cao H, Yu Z. | 03/12/2022 |
| The core autophagy protein ATG9A controls dynamics of cell protrusions and directed migration. | The core autophagy protein ATG9A controls dynamics of cell protrusions and directed migration.
Campisi D, Desrues L, Dembélé KP, Mutel A, Parment R, Gandolfo P, Castel H, Morin F., Free PMC Article | 03/5/2022 |
| The autophagy protein ATG9A enables lipid mobilization from lipid droplets. | The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS., Free PMC Article | 12/25/2021 |
| The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy. | The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy.
Ravussin A, Brech A, Tooze SA, Stenmark H., Free PMC Article | 07/24/2021 |
| The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. | The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP., Free PMC Article | 06/26/2021 |
| The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A. | The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.
Mattera R, Williamson CD, Ren X, Bonifacino JS., Free PMC Article | 05/29/2021 |
| Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. | Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A., Free PMC Article | 05/1/2021 |
| Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. | Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N., Free PMC Article | 03/27/2021 |
| Structure, lipid scrambling activity and role in autophagosome formation of ATG9A. | Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T., Free PMC Article | 02/13/2021 |
| Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion. | Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion.
Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, Sugita Y, Nomura N, Iwata S, Ohsumi Y, Fujimoto T, Nakatogawa H, Kikkawa M, Noda NN. | 02/13/2021 |
| ATG9A upregulation after long-term 5-ARI treatment constitutes a possible mechanism of BPH progression. Inhibition of autophagy via targeting ATG9A, may become an effective method to reduce the risk of BPH progression. | Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression.
Jiang CY, Yang BY, Zhao S, Shao SH, Bei XY, Shi F, Sun Q, Deng Z, Wang XH, Han BM, Zhao FJ, Xia SJ, Ruan Y., Free PMC Article | 03/28/2020 |
| ATG9A promotes HIV-1 infectivity in an Env-dependent manner. The interaction of Nef with ATG9A, however, is not required for Nef to enhance HIV-1 infectivity. | The autophagy protein ATG9A promotes HIV-1 infectivity.
Mailler E, Waheed AA, Park SY, Gershlick DC, Freed EO, Bonifacino JS., Free PMC Article | 03/14/2020 |
| We venture a functional link between ATG7 and ATG9A variants and Primary ovarian insufficiency (POI). We demonstrated that variant ATG7 and ATG9A led to a decrease in autophagosome biosynthesis and consequently to an impairment of autophagy, a key biological process implicated in the preservation of the primordial follicles forming the ovarian reserve | ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.
Delcour C, Amazit L, Patino LC, Magnin F, Fagart J, Delemer B, Young J, Laissue P, Binart N, Beau I. | 06/22/2019 |
| We propose a model where upon autophagy induction, SNX18 recruits Dynamin-2 to induce budding of ATG9A and ATG16L1 containing membranes from recycling endosomes that traffic to sites of autophagosome formation. | SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.
Søreng K, Munson MJ, Lamb CA, Bjørndal GT, Pankiv S, Carlsson SR, Tooze SA, Simonsen A., Free PMC Article | 02/16/2019 |
| AP-4 deficiency causes missorting of ATG9A in diverse cell types, including patient-derived cells, as well as dysregulation of autophagy. | AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Davies AK, Itzhak DN, Edgar JR, Archuleta TL, Hirst J, Jackson LP, Robinson MS, Borner GHH., Free PMC Article | 01/5/2019 |
| the nucleation of autophagosomes occurs in endoplasmic reticulum ubulovesicular regions, where the ULK1 complex coalesces with ER and the ATG9 compartment | Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles.
Karanasios E, Walker SA, Okkenhaug H, Manifava M, Hummel E, Zimmermann H, Ahmed Q, Domart MC, Collinson L, Ktistakis NT., Free PMC Article | 09/8/2018 |
| the identification of ATG9A as a specific AP-4 cargo | AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation.
Mattera R, Park SY, De Pace R, Guardia CM, Bonifacino JS., Free PMC Article | 07/7/2018 |